Squamous papilloma and intraoral related virus induced lesio

Squamous papilloma and intraoral related virus induced lesions

Squamous cell papilloma

clincal feature

a squamous cell papilloma is a generally benign papilloma that arises from stratified squmous epithlium .

Etiology :

Caused by human papillomavirus types HPV-6 and HPV-11.

Oral papillomas are usually painless,  They do not generally mutate to cancerous growths, nor do they abnormal growth or spread.

Site : on the tongue , palate , cheek , or lips

Age : children or young adults.

Gender : The majority of the patients (75%) were females.

Definition

conclusion

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A papilloma (plural papillomas or

papillomata) (papillo- + -oma) is

a benign epithelial tumor growing exophytically (outwardly projecting) in finger-like fronds or in broad base.

In this context papilla refers to the projection created by the tumor, not a tumor on an already existing papilla.

it may appear white or normal colored. It may be pedunculated or sessile.

The average size is between 1–5 cm.

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FOR YOUR ATTENTION

Most of human papilloma virus are cause benign papillomas but there are some have potinatinal to cause cancer as hpv16 and hpv18 are known to cause around 70% of cervical cancer case.

ANY QUEATION ???

Treatment :

Histopathologic features:

Clincal appearance :

Clinical Appearance :

clinical features

 multiple finger-like projection with a fibrovascular core, and is composed of hyperplastic squamous epithelium.

is a small, rough growth resembling a cauliflower.

The lesions often rapidly enlarge (average size <5 mm) and then remain stable, very often for several years.

small fingerlike projections, resulting in an exophytic lesion with a rough or cauliflower like verrucous surface

Most cases require no treatment unless they interfere with eating or are causing pain.

therapy options includes :

cryotherapy, application of a topical salicylic acid , surgical excision and laser ablation

Recurrance is rare

Site : most prevalent HPV skin lesion “common on hands”, but can grow in the

oral cavity .

Age: in children but can be seen in any age group

clinical features

treatment

sponteneous remission within 7-9 months.

Cryosurgery-curtage.

No malignant potentiality.

No recurrent

Age: children and young adults

Site : on the skin of neck, face, eyelids trunk, genitalia ,lip , buccal mucosa , palate and gingiva.

Routes of transmission:

Sexual cotact in adult.

In children and teen_agers: nonsexual , sharing clothes , breathing and swimming.

Florid cases reported in immunocompromised patients.

Verruca vulgaris ( Common Wart)

Molluscum contagiosum

Verruca vulgaris lesions are contagious, and it is thought that some oral lesions occur following autoinoculation

Etiology:

 HPV types 2 and 4 (most common); also types 1, 3, 26, 29, and 57 and others.

multiple papules of the skin or rarely mucous membrane.

Virus induced epithelial hyperplasia

Eitiology:

molluscum contagiosum virus a member of DNA poxvitus group.

Clinical Appearance

Histopathological features:

Treatment:

Histopathologic features:

Multiple papules are pink-smooth

sessile-non tender and non hemorrhagic of 2 to 4 mm in size.

Keratin like plug.

Localized lobular proliferation of surface epithelum. Lobule is filled with molluscum bodies which are keratinocytes that contain large basophilic viral inclusions

Hyperkeratosis, acanthosis hypergranulosis, rete ridge elongation, and large blood vessels at the dermoepidermal junction,( H&E stain.)

There are many treatments and procedures associated with wart removal.

As  Salicylic Acid and Cryotherapy 

Oral wart cannot treated by medication is treat by surgical excision.

molluscum bodies

1.Squamous cell papilloma.

2.Verruca vulgaris.

3.Condyloma acuminatum.

4.Focal epithelium hyperplasia.

5.Molluscum contagiosum.

Clinical feature

Clinical Appearance

Codyloma acuminatum are soft, raised masses with smooth verrucous or lobulated aspects ,the surface commonly shows finger-like projection

these lesions are similar in appearance to papillomas but are usually larger in size and are more clustered.

Also, condylomas are known to be more diffuse and deeply rooted then papillomas

Size: 1 to 1.5 cm

patients who develope Codyloma acuminatum complain of painless bumps and less frequently of pruritus ,discharge or bleeding.

Lesions are commonly multiple(multicentric) and multifocal, effecting the oral and laryngeal regions.

site: on the labial mucosa, soft palate, and lingual frenum

Gender: both sexes are susceptible to infection

Age: prevalence is greatest in persons aged 17-33 years ,with incidence peaking in persons aged 20-24 years

Clinical features

Clinical Appearance

In general, focal epithelial hyperplasia is asymptomatic.

petient is may present because of the appearance, a feeling of roughness or accidental biting of a lesion.

It most commonly presents as a soft smooth flat-topped slightly raised cobblestoned appearance.

It is usually have the same colour as the rest of the mouth, but sometimes paler.

There are often multiple lesions of less than 1cm in diameter.

Age:children and young adults

Gender: no difference between the gender

Race: Native Indians of north and central America

Site:Focal epithelial hyperplasia only affects the lining of the mouth, most commonly:

inside of the lips

inside of the cheeks

sides of the tongue

Condyloma acuminatum

(Venereal wart)

It is sexually transmitted disease (STD) infects the skin.

Etiology:

Approximately 90% of condyloma acuminata are related to HPV types 6 and 11.

These 2 types are the least likely to have a neoplastic potential.

Focal epithelial hyperplasia

Histopathologic features:

treatment:

condyloma acuminatum usually reveals parakeratosis , hyperkeratosis,acanthosis,vacuolated keratinocytes with shrunked nuclei (koilocytes) in the upper layers of the epithelium

It is also known as Heck disease.

What is focal epithelial hyperplasia(Heck disease)?

Focal epithelial hyperplasia is a specific human papillomavirus (HPV) infection in the mouth.

Etiology:

Caused by human papillomavirus types 13 or32 (HPV)

Condylomas can cause disfigurement and are difficult to treat.

It is best to surgically remove all of the lesions simultaneously to lessen the probability of autoinoculation.

Excision with lasers may lead to spread of the virus via airborne particles and is not advised.

Podofilox (Condylox), an antimitotic topical agent used to treat genital and anal condylomas,has not been approved by the FDA for oral use but may be effective in treating oral condylomas

koilocytes

Histopathologic features:

Treatment and Prognosis

The histopathological study revealed a squamous epithelium with focal parakeratosis, hyperkeratosis, acanthosis, verrucous proliferation and marked papillomatosis hyperplasia of basal cells, and isolated perinuclear cellular vacuolization (koilocytosis), cellular binucleation and nuclear irregularities. The presence of epithelial dysplasia was not detected. There were well isolated mitosoid cells.

Spontaneous regression is seen in

almost all of cases after a period of months or years.

For aesthetic purpose: Surgical Excision can be performed

No Recurrence

No malignant transformation

mitosoid bodies

Squamous epithelium with parakeratosis

, acanthosis and marked papillomatosis