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Transcript

Datura Poisoning

These Plants contains Highly Cholinergic Tropane Alkaloids

  • Atropine
  • Scopolamine
  • Hyoscyamine

These plants have long histories of hallucinogenic use and have been connected with sorcery, witchcraft, native medicine, and magico-religious rites dating back to 1500 BC.

Datura

  • In China, used to treat asthma, chronic bronchitis, pain, and flu symptoms.

  • In Mexico, used to lessen pain of child birth.

  • In Africa, to treat Bronchial Asthma and Pulmonary problems.

  • In India, used in ritual prayers and as aphrodisiac.

Thank You!!

  • Angel’s trumpet
  • Devil’s Apple
  • Devil’s Trumpet
  • Jimsonweed
  • Sorcerer’s Herb
  • Stramonium
  • Thorne-apple

Clinical Manifestations

  • Not detected on Toxicology screen

  • Diagnosis made on Clinical Symptoms

  • Presence of Tropane Belladona Alkaloids in Urine sample by Gas chromatography-mass spectrometry
  • Absorbed through GI tract.

  • Gastric Lavage is Indicated in the first 1 - 2 hours.

  • Repetitive dose of Activated Charcoal not indicated as GI motility reduced inducing multiple episodes of vomiting and abdominal ileus.

  • Physostigmine is the Antidote.

  • Unlike physostigmine, neostigmine has a quaternary nitrogen; hence, it is more polar and does not enter the CNS. Its effect on skeletal muscle is greater than that of physostigmine. Neostigmine has moderate duration of action, usually two to four hours.

  • Physostigmine is to be discontinued if excessive vomiting, salivation, diarrhoea and urination occur.

  • Rapid Infusion causes Bradycardia, Hypersalivation and Convulsions.
  • Blurring of Vision (Mydriasis)
  • Clumsiness
  • Dizziness
  • Confusion (Delirium)
  • Difficulty in breathing
  • Dry Mouth
  • Tachycardia
  • Arrythmia
  • Vivid Hallucination
  • Muscle weakness
  • Urinary retention
  • Fever
  • Flushing
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