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FARMACOS ANTIADRENÉRGICOS

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by Analucia Atuncar Yepez on 9 September 2013

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Transcript of FARMACOS ANTIADRENÉRGICOS

FÁRMACOS ANTIADRENÉRGICOS
ADRENALINA
Hormona, catecolamina
Secretada por glándula suprarrenal
80% A / 20% NA
respuesta rápida ante estres
regula parametros fisiológicos: metabolismo energético y gasto cardiaco
RECEPTORES ADRENÉRGICOS
Antagonistas de los receptores alfa- adrenérgicos:
GRACIAS!!
UBICACIÓN DE RECEPTORES
BIOSÍNTESIS
Gránulos cromáfines
No selectivos:
Fenoxibenzamina: ant. de Ach, histamina, etc
Fentolamina:
reversible, acción corta
PA
GC y FC
BLOQUEADORES DE RECEPTORES ADRENÉRGICOS
Antagonístas de los receptores beta -adrenérgicos
PROPANOLOL:
Antagonista puro
mas potente
bloquea por igual B1 y B2
CARVEDILOL*:
Antagonista no selectivo (beta y alfa1)
NEBIVOLOL*:
Antagonista B1 selectivo
vasodilatación ON endotelial
*eficaces en tto de ins. cardiaca
NOTA:
La mayor parte de beta bloqueantes, inactivos para receptores B3. No influyen en lipolisis
Selectivos (alfa-1)
prazosina: 1er antagonista
doxazosina + terazosina: semivida mas larga.
vasodilatación
PA
No aumenta liberacion de NA no taquicardia
Tamsulosina: ant. receptores alfa- 1A
selectividad por vejiga
menos hipotensión que otros fármacos
RECEPTORES ALFA
RECEPTORES BETA
Selectivo alfa - 2
yohimbina: uso experimental
Atuncar Yepez, Analucia
q
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