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White Blood Cells

Transcript: The white blood cell is replaced by others that are produced in the center part of the bones(bone marrow) The function of white blood cells are to protect the body from foreign invaders unlike red blood cells that mostly carry oxygen. There is also more than one type of white blood cell Thank You! By Oliver Cardona E block White blood cell Thanks to these awesome people :D There are all kinds of white blood cells but I'm only going to go over the most important Neutrophils and Lymphocytes. Neutropilis are like the first responders of the body infection or injury. Lymphocytes are the t killer cells, they kill any bad pathogen when it enters the body White blood cells are found in the bloodstream and they are one of the many defenses to protect the body from invaders http://www.livestrong.com/article/106131-white-blood-cells-functions/ 3/19/15 The Different types of white blood cells Location of White Blood Cells White blood cell diseases http://www.buzzle.com/articles/white-blood-cells-diseases-and-disorders.html http://www.ehow.com/facts_7320449_do-white-blood-cells-reproduce_.html White Blood Cells Function of White Blood cells What happens if a white blood cell dies? There are many but one of the most deadly is HIV/AIDS because it kills white blood cells and leaves you vulnerable to other infections. Its one of the deadliest because there are no known treatment for it. 62 ECG bpm

White Blood Cells

Transcript: Diffrent Types Of White Blood Cells Granulocytes Neutrophils This is the most common White blod cell. It is carried through the blood to the sites of infection. It digests bacteria, virus particles and fungi They dicharge granules into damaged tissue spaces to promote inflamation and blood flow. Eosinophils They moderate allergic reaction, and defend against parastic worm infestation. Agranulocytes It is characterized by the presence of granules in their cytoplasm. They have 3 major types Thymus (T) Cells It's involved in cell mediated immunity. These attack foreign and tumor cells It also produces toxic granules that contains powerful enzymes Bursa Derived (B) Cells It has a major cellular components of the adaptive immune response It also reponds to pathogens by producing large quantities of antibodies Natural Killer (NK) Cells It has a major role in defending the host from both tumors and virally infected cells They are activated in response to a family of cytokines They are more common in the lymphatic system Monocytes To have a resident macrophages and dendritic cells under normal states Response To have a inflammation signals, so monocytes can move quickly There are 2 types of diseases in White Blood Cells Lymphocytopenia HIV and AIDS Low Blood Cell Count It reduces the number of neutrophils in the body What are they specilized to do? disease, kill bacteria, fight allergic reactions, destroy old and/or damaged cells Interesting Facts The red bone marrow stem cell give rise to almost all of the white blood cells They are part of the immune system, found in the blood White blood cells die very easily They are specilized to fight bacteria Bibilography - The normal White Blood Cell count 5,000 to 10,000 per cubic mm. Group 1 White Blood Cells By Hannah & Rebecca They fight Diseases Leukemia Lymphocytes Basophils They are part of the innate immune system wikipedia.com wisc - online.com On average, the normal man has about 7000 White Blood Cells in a microletre. (really small) Neutropenia Group 2 High White Blood Cell Count They also play multiple roles in the immune function Replenish Any Questions? wiki.answers.com howstuffworks.com

White Blood Cells

Transcript: Immune Response Enzymes and Clotting factors Red Blood Cells Agranulocytes- no granules Monocytes- phagocytic- engulfs foreign invaders Lymphocytes- B&T cells- B cells make antibody and memory cells Blood Clotting Blood Transport of dissolved gases Distributes nutrients Transports metabolic wastes Delivers enzymes & hormones Regulates pH & electrolyte composition Restricts fluid loss (clotting reaction) Defends against toxins & pathogens Regulates body temperature vascular spasm Platelet plug Coagulation Clot retraction Fibrinolysis Blood Granulocytes- granules in cytoplasm neutrophils- lobed nucleus - attack bacteria eosinophils- allergies and parasites basophils - damaged tissue- histamine- inflammation Hemoglobin- responsible for transport of gasses – made of 4 globular proteins – each protein = associated with heme – holds iron – allows for molecule to bind to o2 – Gives blood its red color- Platelets biconcave bendy + flexible no organelles White Blood Cells Transports gasses diff types

white blood cells

Transcript: white blood cells dont live for very long, only a few days or a few weeks a drop of blood contains on average 7,000 to 25,000 white blood cells look a bit like a white blob that can morph around and grab unwanted germs and virus' thanks for listening white blood cells by rebekah white blood cells at a time

White Blood Cells

Transcript: What things can you do to not get diseases that effect the White Blood Cell? What diseases effect a White Blood Cell? What is a White Blood Cell count? Bone morrow cancer HIV AIDS Lupus disorders with bone morrow Cancer anywhere in the body where are White Blood Cells located? What is the job of a White Blood Cell? Where are White Blood Cells made? Where are White Blood Cells produced? White Blood Cells

white blood cells

Transcript: thE WHITE BLOOD CELL PLAYS A VITAL ROLE IN THE IMMUNE SYSTEM. THEY CIRCULATE AROUND THE BLOOD STREAM LOOKING FOR BACTERIA, VIRUSES, PARASITES AND ANY OTHER CELLS OR OBJECTS THAT SHOULDN'T BE THERE after the invader is elminated most of the white blood cells self destruct, others are left as memory cells which help the immune system activate much faster, and to gain immunity to the invader. white blood cells are colourless and contain no hemoglobin. it contains a nucleous and has a irregular shape. they ARE MUCH BIGGER THAN A RED BLOOD CELL BUT THEY CAN ALSO CHANGE THEIR SHAPE EASIALY TO FIT THROUGH THE WALLS OF A BLOOD VESSLE. t cells cannot recognize an antigen unless it has been processed and presented by another white blood cell called an antigen-presenting cell. enzymes in the antigen presentining cell break the antigen into fragments some fragments are combined with HLa molecules then transported to the cells surface. the t cell can recognize the antigen fragment when it is presented to by the hla molecule. when activated, the complement proteins can; trigger inflammation, attract eater cells such as macrophages, coat intruders so that the eater cells are more likely to eat them, kill them white blood cells communicate with eachother and with other cells of the body via chemical messangers cytokines are they small molecules that are relaesed by cells to modify the behaviour of surrounding cells. cytokines play a major role modulating the immune system. they are a bond to the molecule group proteins. leukemia is cancer of the white blood cells. It begins with one abnormal cell that continuously replicates itself the result is the cell not fuctioning properly, they do not fight infections and they begin to infect other wbc's and rbc's.

White Blood Cells

Transcript: Thrombocytes (Platelets) Leukocytosis Leukocytes Thrombocytes Hematopoietic Growth Factors and Progenitor Cells Low platelet count Some drugs interact with membrane surface proteins of platelets Drug induced immune vs nonimmune thrombocytopenia Some drugs that cause thrombocytopenia: Sulfonamides, Penicillin, Heparin Pluripotent cell -> Megakaryoblast -> Megakaryocyte -> Platelets One megakaryocyte -> 1000 platelets Low WBC count in blood Generally shouldn't have less that 3500 in every microliter of blood Condition in bone marrow causes leukopenia Other causes: drugs, radiation, infection, autoimmune disorders, anemia, vitamin deficiencies, viral infection Symptoms: Anemia, menorrhagia, fatigue, fever Treatment: stimulate bone marrow, steroids Granulocytes Neutrophils Eosinophils Basophils What is a thrombocyte? Platelet regulation Drug-induced thrombocytopenia White Blood Cells by Joanna Tam Granulocytes Hematopoiesis = formation of blood cell components Leukopoiesis = formation of WBCs in bone marrow Pluripotent stem cells => lymphoid and myeloid stem cells Lymphoid stem cells => lymphocytes Myeloid stem cells => RBC (erythrocytes), neutrophils, monocytes, eosinophils, basophils, megakaryocytes Gene expression Bibliography Platelet Formation Agranulocytes Aka white blood cell 400-10,000/microL blood Contain nucleolus and mitochondria Amoeboid movement Some are phagocytic Classified by color when stained Types of Leukocytes Lymphocytes More common in lymphatic system Two types: B cells and T cells Lifespan: hours-years Monocytes Mature into macrophages Move to tissues Lifespan: months What is a Leukocyte? "Thrombocytopenia - Drug Induced: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine. Web. 27 Mar. 2015. <http://www.nlm.nih.gov/medlineplus/ency/article/000556.htm>. "Thrombopoietin." Wikipedia. Wikimedia Foundation. Web. 27 Mar. 2015. <http://en.wikipedia.org/wiki/Thrombopoietin>. "Leukopenia | MD-Health.com." Leukopenia | MD-Health.com. Web. 27 Mar. 2015. <http://www.md-health.com/Leukopenia.html>. Wikipedia. Wikimedia Foundation. Web. 27 Mar. 2015. <http://en.wikipedia.org/wiki/White_blood_cell#Neutrophil>. "Leukocytes." Untitled Document. Web. 27 Mar. 2015. <http://bme.virginia.edu/ley/leukocytes.html>. Disorders Disorders What are Thrombocytes? Elevated WBC levels Usually an inflammatory response; infection Affects specific WBCs and increases its role Ex: Eosinophilic leukocytosis, monocytosis, lymphocytosis Drug-Induced Thrombocytopenia Platelet Regulation Basophils Allergic and antigen response Excrete histamine and heparin Release chemicals that attract other WBCs to infection site Lifespan: hours-days What is a leukocyte? Categories of leukocytes Types of leukocytes Leukopoeisis Disorders: Leukopenia, Leukocytosis Erythropoietin - RBC Granulocyte Macrophage Colony Stimulating Factor - Granulocytes and monocytes Interleukin - Leukocytes Thrombopoietin - Platelets Stem Cell Factor - Different blood cells Hematopoietic Growth Factors and Progenitor Cells Leukopenia (Neutropenia) Neutrophils 1st responders to microbial infection Phagocytic Lifespan: 6 hours Move to injury via chemotaxis Eosinophils Population changes during the day, seasonally, during menstruation Rare in blood, found in mucous membranes Deal with parasitic infections Directed by chemoattractants Phagocytic but don't ingest cells Lifespan: 8-12 days Leukocytes Outline Blood cells that work to stop bleeding (hemostasis) Fragments of cytoplasm No nucleus Found only in mammals Stored in the spleen Contain organelles Main function: stop bleeding at interrupted areas of the endothelium Three steps: adhesion, activation, aggregation Agraulocytes Lymphocytes Monocytes Regulated by thrombopoietin Also regulates number of megakaryocytes Low number of platelets -> thrombopoieten participates in generating more megakaryocytes Hematopoiesis and Leukopoiesis

white blood cells

Transcript: BUT... If a white blood cell senses the chemicals made by a microbe, they will swallow up that microbe and digest it! Have a short life, living few days to a few weeks. I work in the immune system! To keep the corporation healthy, I circulate in the blood so I can be transported to an area where an infection has developed. White blood cells are there to protect the body from bacterium, virusus, and any other disease. They are like little cops floating around in your blood waiting to chase invaders, like viruses and bacteria. If the Human Body Corporation fire me, the person would die within hours or days! Why? Because the body won't have any defenses from a disease or infection. For example: My department All about me! You can find me within your blood, I always hang out with the blood. My name is Leukocytes, or you can also call me white blood cell! and I'm like a fluffy ball! Here's a picture of me. Leukopenia-involves a reduction of circulating white cells to counts of less than 5,000. I'm very important, one day without white blood cells in your body you would get very ill! White blood cells fight against viruses and bacteria everyday. White Blood Cells My Job!! What if!? The immune system will shut down immmediatly! There are 5 types white blood cells: basophil, eosiniphil ,lymphocyte, monocyte, and neutrophil. Leukemia-characterized by an abnormal increase in the number of white cells, is one of the most dangerous of blood disorders. Interesting facts One drop of Blood can contain from 7,000 to 25,000 white Blood cells. Genetic Disorders How important am I? If an invading infection fights back and persists, the number of white blood cells will significantly increase!

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