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Congenital Heart Disease

Transcript: Preventing Damage Trivia Video The cause is unknown with majority of people with Congenital Heart Disease Genetic or Chromosomal abnormalities in the child may be a cause Medication, drugs or alcohol during pregnancy Maternal viral infections such as measles during the first trimester of the pregnancy Detection Many Congenital Heart Diseases are detected before birth Use a Echocardiography on the fetus to create a picture of the heart Can diagnose the disease based on the ultrasound Other ways to detect Heart Disease after birth are: Electrocardiogram, Chest x-ray, Pulse Oximetry, Cardiac Catheterization Treatment Many do not show signs Rapid breathing Cyanosis (blueish tint to lips, skin, fingernails) Fatigue Poor blood circulation Usually only shown in newborns Week 5- The heart begins to form Week 6- The heart begins to pump blood These 2 weeks are the most crucial to the babies heart development. When during the prenatal development is the most damage done? Prevention If you would like to volunteer, ride or come to the event visit: Congenital Heart Disease Signs and Symptoms Congenital Heart Disease occurs at birth It happens when the blood vessels near the heart does not develop fully before birth It is present in about 1% of live births Causes more deaths in the first year of life then any other defects Defects occur when the fetus is developing in the uterus Affects approximately 1 and 100 children Summary Not everyone with a congenital heart defect needs treatment, but for those who do some options are... Surgical Procedures Cardiac Catheterization Heart Transplants Lots of additional medication 1) What week in the pregnancy does the heart begin to form? 2) Name 2 ways to try to prevent a congenital heart defect? 3) Name 3 long term effects of congenital heart disease. Gabrielle's Ride Long Term Effects Most congenital heart defects can not be prevented during pregnancy The women should obviously avoid tobacco, alcohol and any non-prescription medication The women should just be as healthy as possible and act as if she would with any normal healthy pregnancy Danger to the Developing Fetus Gabrielle's Ride is a charity cycle that takes place annually in Oakville. There is a tyke ride, a family 25km ride, a 50km ride and a 100km ride you can participate in, you can volunteer or just come the the music, games and fun. We raise money in support of SickKids Foundation primarily towards Congenital heart disease. Causes The critical time for prevention is before pregnancy Get the vaccine for rubellus (measles) Take prenatal vitamins when pregnant The fetus will have issues developing properly There brain, eye sight and breathing may be affected With this disease during the pregnancy the blood flow is weak causing it not to circulate properly through the body Blood clots Heart failure Heart rhythm problems Pulmonary hypertension (shortness of breath, extreme tiredness, dizziness) Endiocarditis (muscle and joint pain, loss of appetite, night sweats, shortness of breath) Respiratory tract infection impaired memory

Heart Disease-Congenital Heart Disease

Transcript: if too much of the Dvl protein reaches the PCP pathway than the outcome of cardiac bifidia phenotypes nearly always causes ventricular defects It affects nearly 1% (40,000) births per year in the U.S. The number of babies born with some CHD's, especially mild types, compared to those without is increasing Approximately 25% of babies with this disease have critical CHD; they usually need surgery or similar procedures within the first year of their life Researchers estimate that in 2010, about 1 million U.S. children and 1.4 million U.S. adults were living with this condition Infant deaths due to this condition usually occur in the first 28 days of life 4.2% of all infantile deaths are due to CHDs Nearly half of of the deaths due to CHDs occurred during infancy About 95% of babies born with non-critical CHD are expected to live for 18 years The population of people with CHDs is increasing because medical care for them is increasing. Diseased pathway Normal pathway Thank You! The coordination of wide scale planar polarity that provides each individual layer to work cohesively with each other. Target each stage of heart development in terms of the emergence of polarized structures dependent on cell type. Lp homozygote mutations result in ventricle defects due to the extension of the cell's membrane without the movement of the other major organelles Congenital Heart Disease is an abnormality in the heart's structure at the time of birth. It is often considered a childhood condition since the advances in surgical treatment allows the affected to live long, healthy lives. Planar Cell Polarity (PCP) is a modulate pathway, where multiple steps of cell signaling can occur consecutively, that determine critical changes that occur during heart development. PCP is responsible for ensuring correct cardiac specifications. Treatments Graphics Heart Disease-Congenital Heart Disease and Cardiomyocyte hypertrophy symptoms Frizzled (Fz) Disheveled (Dvl) Prikled (Pk) Vangl/Srabismus (Vangl) Celsr/Flamingo (Celsr) Diego (Dgo) *where often Pk and Vangl antagonize Fz and Dvl REsearch 3 Main Molecular Categories The CDC is working with numerous elite universities such as Emory and Duke to track individuals with CHDs across the lifespan. They are trying to understand the health issues and needs of these people to work to improve their lives. The primary research goal of this disease is to find the exact cause and risk factors for this disease. The CDC wants to expand their population statistics by tracking the CHDs among adolescents and adults, instead of just newborns and youngsters. Causes Researchers are not certain of what causes heart defects, but they believe some medical conditions, medications and genetics may play a role in it. Risk factors may include: German measles (if the mother had rubella while pregnant) Diabetes (if the mother had type 1 or 2 diabetes) Medications (if the mother took certain medications while pregnant) Heredity Bibliography Graphics Tissue Specific Factors Core Polarity Genes Symptoms and Prognosis Hayley Mahnke Anita Yegappan *symptoms may not appear until later on in life Abnormal heart rhythms (heartbeat can be too slow, fast or irregular; may cause death) Heart infection (endocarditis- bacteria from other parts of the body enters the bloodstream and lodges in the heart. This can damage and destroy the heart valves and cause strokes) Stroke, heart failure Pulmonary hypertension (more blood flow to the lungs, increasing pressure, causing heart's lower right chamber to work harder and eventually weaken) Heart valve problems (valves may be abnormal depending on the case) Death Prognosis Symptoms as an adult may include; abnormal heart rhythms a bluish tint to the skin shortness of breath tiring quickly upon exertion dizziness or fainting swelling of body tissue or organs when both Dvl and Fz do not synergize the pathway is halted and remains uncompleted often resulting in cardiopalmonary malformations Disease description The diseased PCP pathway can be effected in 6 different ways

Congenital Heart Disease

Transcript: Congenital Heart Disease is autosomal dominant. Testing/Screening Treatment/Prevention Congenital Heart Disease Sex Linked? Autosomal Dominant Or Autosomal Recessive? Congenital heart defects are the most common type of birth defect in the United States, affecting nearly 1% or about 40,000 births per year Cardiac Catheterization-During cardiac catheterization (KATH-e-ter-ih-ZA-shun), a thin, flexible tube called a catheter is put into a vein in the arm, groin (upper thigh), or neck. The tube is threaded to the heart. Pulse Oximetry-For this test, a small sensor is attached to a finger or toe (like an adhesive bandage). The sensor gives an estimate of how much oxygen is in the blood. Echocardiography-Echocardiography (echo) is a painless test that uses sound waves to create a moving picture of the heart. During the test, the sound waves (called ultrasound) bounce off the structures of the heart. A computer converts the sound waves into pictures on a screen Anyone and everyone is at the risk of being born with disease or even catching the disease. Population effected Who's at risk? Cause of Defect Congenital Heart Disease is sex linked. Some congenital cardiac abnormalities are inherited and may be transmitted as autosomal or sex-linked traits. Works Cited Listen to your child's heart and lungs with a stethoscope Look for signs of a heart defect, such as cyanosis (a bluish tint to the skin, lips, or fingernails), shortness of breath, rapid breathing, delayed growth Echocardiography (echo) is a painless test that uses sound waves to create a moving picture of the heart. During the test, the sound waves (called ultrasound) bounce off the structures of the heart. A computer converts the sound waves into pictures on a screen. In the majority of people, the cause of congenital heart disease is unknown. However, there are some factors that are associated with an increased chance of having congenital heart disease. These risk factors include: Genetic or chromosomal abnormalities in the child, such as Down syndrome Taking certain medications or alcohol or drug abuse during pregnancy

Congenital Heart Disease

Transcript: Congenital Heart Disease The causes of congenital heart disease may be either genetic or environmental, but is usually a combination of both. Diagnosing: Several cases can be diagnosed in the first few months after birth. Also, at routine medical checks. 3 Tips Treatments for Congenital Heart Disease, are medicine, which can control the heart beat that isn't regular and make the heart stronger until the defect can be fixed. A procedure call heart catheterization, will find out details about the heart defect or sometimes will repair the defect. And then there's surgery. If it is a newborn with the defect, surgery will be delayed until the baby is stronger. But if the defect threatens the baby's life, surgery will be done right away. Doctor Miller is working on research for Congenital Heart Defects. About 8 out of every 1,000 children are born with Congenital Heart Disease. Range from simple defects with no symptoms to complex defects with severe, life-threatening symptoms. Some signs could be, shortness of breath, cyanosis, syncope, heart murmurs, under developed limbs and muscles, poor feeding or growth, or respiratory infections. Some more symptoms are the child could be tired and sleep alot. 1. Bonding or connecting with others who have had similar experiences. 2. Speaking in public/telling stories in counseling or support groups or in families. 3. Caring for the child appropriately so that you can enjoy his/her steps of progress. Symptoms

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