Transcript: Stem Cells Problems What are Platelets? Sources Yellow mainly fat cells What is Bone Marrow? Requires examination on bone marrow tissue How does a stem cells transplant go? Stem cells are cells that turn into either red blood cells, white blood cells, or platelet. (prevent blood clots) They can also turn into.. Muscle cells Fat cells Bone cells Blood cells Made in bone marrow. Leukemia multiple myeloma myelodysplastic syndrome (MDS) pancytopenia anemia and more Born- All red bone marrow Aged- Turn yellow Anemic- Turn back to red Other http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html Red: Produces red blood cells, white blood cells, and platelets Carry oxygen to tissues Bone marrow is the fatty network of connective tissue that fills the cavities of bones. It is soft and spongy. Bone Marrow http://www.news-medical.net/health/What-is-Bone-Marrow.aspx By: Katie, Domonique, and Katelyn What does it do? http://www.cleanvideosearch.com/media/action/yt/watch?videoId=qfOeGWRmyl0
Transcript: Created by Riya & Dea What is bone marrow? Bone Marrow Bone marrow is the spongy tissues inside bones in our bodies. It contains immature cells known as stem cells. Many people who have diseases such as Anemia and Leukemia, rely on bone marrow or core blood transplants to survive. Bone marrow also contain stem cells. Diagram of the inside of a bone Bone marrow transplants A bone marrow transplants are used for various reasons; To replace bone marrow in genetically healthy, functioning bones. To regenerate a new immune system that will fight existing or residual leukemia or other cancers Transplants Transplants More transplant information Bone marrow transplants are the leading treatment conditions for that threaten the bone's condition and it's ability to function. A transplant can help rebuild the body's capacity to produce blood cells and bring their numbers to normal levels. Illnesses that are treated with a bone marrow transplant include both cancerous and noncancerous diseases. Red and yellow bone marrow Red and Yellow bone marrow Bone marrow comes in two types; red and yellow. Within the red bone marrow the red and white blood cells and also the platelets are manufactured. From the yellow bone marrow, they are distributed throughout the body then all through the circulatory system. Side affects The affects of bone marrow transplants The side affects of bone marrow are similar to those of chemotherapy. Those side affects are; An infection Nausea and vomiting Mouth sores Diarrhea Fatigue Low levels of red blood cells, which can cause anemia Low levels of platelets, which can decrease how well blood can clot Game Questions 1. What are bone marrow and stem cells? 2. What is one of the reasons bone marrow transplants are used? 3. What is a bone transplant? 4. What two types of bone marrow does the bone marrow come in? 5. What does a red bone marrow do? 6. What does a yellow bone marrow do? 7. Name a side affect of having a bone marrow transplant Why does a patient need a bone marrow transplant and what happens if they don't get one? BONUS QUESTION Questions Answers 1. 2. 3. 4. 5. 6. 7. Bonus question answer Stem cell or bone marrow transplants are used to replace bone marrow that has been destroyed by cancer or destroyed by the chemo and/or radiation used to treat the cancer. VIDEO https://www.bing.com/videos/search?q=bone+marrow+what+it+is+short+video&&view=detail&mid=55F3FB9DDC9A98097A4E55F3FB9DDC9A98097A4E&&FORM=VRDGAR Video and Resources http://www.cancer.ca/en/cancer-information/cancer-101/what-is-cancer/the-blood-and-bone-marrow/?region=on https://www.cancer.org/cancer/bone-cancer/about/what-is-bone-cancer.html https://www.healthline.com/health/bone-marrow-biopsy#why https://www.healthline.com/health/cancer/multiple-myeloma-outlook Resources Resources
Transcript: Leukemia Lymphoma Inherited Blood Diseases Sickle Cell Anemia What is it? The soft, spongy area in the center of the larger bones in your body. Bone Marrow produces the cells that make up your blood including red and white blood cells and platelets. and why you should donate A Surgical Procedure Remove Liquid Marrow from the back of Pelvic Bones. Insert a hollow needle 1 - 200 times. How Does This Help the Patient? Make Bone Marrow Donations Make Peripheral Blood Cell Donations Blood is taken from one arm, run through a machine, and put back in your other arm. For 5 days before donation: Injections of Filgrastim Only take about 8 hours. What can I do? How do I Join? Go to BeTheMatch.org Swab your own cheek with the kit the registry sends You could then be a match for doctors that search every day. Bone Marrow Donation Who's Affected? What's the Problem? Your healthy Bone Marrow will be given to he patient through injections. It will then produce healthy blood cells and fight disease. Peripheral Blood Cell Donation 2 classrooms full of children 1 person every 4 minutes 150,000 people per year Bone Marrow
Transcript: Bone Marrow - Bone marrow is the soft tissue that fills the inside of the bone - Bone marrow is found in long bones - Bone marrow produces 200 billion new red blood cells every day Bone Marrow Bone Marrow - Red bone marrow is found in flat bones such as the hip, breast bone, skull, ribs, vertebrae, and shoulder blades. - The main point of red bone marrow is to create blood cells. - Red marrow is found on the end of the bone. Red Bone Marrow Red Bone Marrow - Yellow bone marrow produces fat,cartilage, and bone. - Yellow bone marrow contains mesenchymal stem cells which develop into bone, fat, cartilage or muscle cells. - Yellow bone marrow is found inside the center of long bones. Yellow Bone Marrow Yellow Bone Marrow -The main point of red bone marrow is to remove carbon dioxide while carrying oxygen. -Red Blood Cells live for 120 days and die. - Without blood cells you won't get enough oxygen. Red Blood Cells Red Blood Cells - Aplastic Anemia is where the bone marrow doesn't create blood cells. - Leukemia is a bone marrow disease which creates abnormal blood cells. - Diseases like lymphoma, can spread into the bone marrow and affect the production of blood cells Bone Marrow Diseases Bone Marrow Diseases -A bone marrow transplant helps replace damaged bone marrow and helps create new blood cells. -Bone marrow transplants are used for diseases like leukemia and lymphoma. -Bone marrow transplants are extremely painful. To execute it you must go into the back of the pelvic to find the marrow then puncture the bone to get the marrow. To get the marrow you must use a syringe. Bone Marrow Transplants Bone Marrow Transplants - https://www.healthline.com/health/bone-marrow-transplant - https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bone-marrow - https://medlineplus.gov/bonemarrowdiseases.html - https://www.medicalnewstoday.com/articles/285666.php - https://pediaa.com/difference-between-red-and-yellow-bone-marrow/ - https://www.britannica.com/science/bone-marrow - https://www.sciencedaily.com/terms/bone_marrow.htm Sources Sources
Transcript: What is it? What does it do? TYPES Stroma Adipose Tissue Does every Bone Carry Bone Marrow? Treatment Hematopoietic Aplastic Anemia Anti-thymocyte globulin Better picture of Red Bone Marrow BONE MARROW
Transcript: Madeleine Riewoldt Includes a group of disorders than can be either inherited or acquired. Most common inherited failure is Aplastic Anemia which can lead to Leukaemia. Aplastic Anemia: Rare Develop suddenly or slowly Treatments: Blood transfusions Blood and marrow stem cell transplants Medicines Effects: The body doesn't make enough red and white blood cells or platelets. Can and will kill you. Bone Marrow Yellow Bone Marrow Found: Primarily found in the flat bones (e.g ribs, skull) In children it is also found in the medullary cavity of long bones such as the femur. As the child ages, red bone marrow is replaced by yellow bone marrow. Interaction With Other Organs Bone Marrow Failure (Aplastc Anemia) Red Bone Marrow Skin: Platelets create blood clots behind a cut or graze to stop bleeding. Allowing skin to heal. Lungs: Red blood cells carry oxygen from the lungs and to other organs/tissue. All: White blood cells fight against infections or diseases; allowing the body to continue as best it's able Red blood cells transport nutrients from the stomach to other organs or tissues. By Sarah Shaw Diagnosed in August of 2010 Died this year in February. 125 cases diagnosed every year 30 cases are children. Luekaemia? A small number of patients with aplastic anaemia may develop leukaemia. Why? Lack of cells within the blood which are replaced by fat cells. What is Bone Marrow? Also called Myeloid Tissue Is a soft, semi-solid, gelatinous tissue Found in the axial skeleton Highly vascular Contains many blood vessels/capillaries. There are two types of bone marrow: Red bone marrow (Hematopoietic bone marrow Yellow bone marrow (Stromal bone marrow) Functions: Contains Hematopoietic stem cells Hematopoietic stem cells then develop into red blood cells, white blood cells, or platelets. White blood cells = few hours - few days Platelets for = 10 days, Red blood cells = 120 days. Under certain circumstances; the kidneys produces/releases a hormone that encourages me to produce more red blood cells. Infections result in more white blood cells Bleeding Results in more platelets in response to bleeding. Functions: Stores adipocytes whose triglycerides can serve as a source for energy. Found: In the hollow interior of the diaphyseal portion (shaft) of long bones. Complete absence of Hematopoietic cells enhanced under microscope
Transcript: There is red marrow and yellow marrow. Red: Is where the blood cells are made. Yellow: in the hollow middles of long bones and is mostly fat. Autologous bone marrow transplant: Stem cells are removed from the patient before they receive high-dose chemotherapy or radiation treatment. The stem cells are stored in a freezer. After high-dose chemotherapy or radiation treatments, their stems cells are put back in your body to make (regenerate) normal blood cells. This is called a rescue transplant. Allogeneic bone marrow transplant: The term allo means other. Stem cells are removed from another person, called a donor. Most times, the donor's genes must at least partly match your genes. Special blood tests are done to see if a donor is a good match for you. A brother or sister is most likely to be a good match. Sometimes parents, children, and other relatives are good matches. Donors who are not related to you may be found through national bone marrow registries. Umbilical cord blood transplant: This is a type of allogeneic transplant. Stem cells are removed from a newborn baby's umbilical cord right after birth. The stem cells are frozen and stored until they are needed for a transplant. Umbilical cord blood cells are very immature so there is less of a need for matching. But blood counts take longer to recover. Anemia Bleeding in the lungs, intestines, brain, and other areas of the body Cataracts Clotting in the small veins of the liver Damage to the kidneys, liver, lungs, and heart Delayed growth in children who receive a bone marrow transplant Early menopause Graft failure, which means that the new cells do not settle into the body and start producing stem cells Graft-versus-host disease, a condition in which the donor cells attack your own body Infections, which can be very serious Inflammation and sorenes in the mouth, throat, esophagus, and stomach, called mucositis Pain Stomach problems, including diarrhea, nausea, and vomiting Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Donors Step one: The bone marrow cells are harvested. Step two: The patient will undergo high levels of radiation or chemotherapy to eliminate the cancer cells. Step three: The donated stem cells will be passed into your body through the central line. The process can take from half an hour to several hours to complete, depending on the type of blood cells being used. Step four: The engraftment usually occurs 15-30 days after the transplant takes place. During this period, you will need to have regular blood transfusions because you will have a low number of red blood cells. What is Bone Marrow? Bone Marrow If you have a bone marrow disease, there are problems with the stem cells or how they develop. Leukemia is a cancer in which the bone marrow produces abnormal white blood cells. With aplastic anemia, the bone marrow doesn't make red blood cells. Other diseases, such as lymphoma, can spread into the bone marrow and affect the production of blood cells. Other causes of bone marrow disorders include your genetic makeup and environmental factors. The harvest is collection of marrow cells from the patient or donor. They collect 1-2 quarts of bone marrow usually from the hip bone. Symptoms? whats it cost? Hard to find the best donor. Siblings are the best option The more siblings you have the better changes you have. Harvest Types of transplants How does it work? Who needs it? The soft fatty substance in the cavities of bones, where blood cells are produced. Made up of Stem cells References Steps of procedure Led by Dr. E. Donnall Thomas, Fred Hutchinson Cancer Research Center scientists pioneered the development of bone marrow transplantation to treat leukemia and other blood cancers. Dr. Thomas and his lifesaving work were recognized in 1990 with the Nobel Prize in physiology or medicine. Who decides and where? You need to get evaluated by your doctor to see what treatment is best. Cancer Treatment centers of America do allot of them. It may range from $10,000 to $25,000. Your transplant center will assist you in determining if your insurance will cover the testing of donors. If you don’t have this coverage, you’ll be told of your financial responsibility. Issues of rejection? Chest pain Chills Drop in blood pressure Fever Flushing Funny taste in the mouth Headache Hives Nausea Pain Shortness of breath http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm http://www.nbmtlink.org/resources_support/rg/rg_costs.htm http://www.cancercenter.com/midwestern/medical-departments/hematology-oncology/?source=GOOGLEWE&channel=paid%20search&c=paid%20search:Google:Google%20-%20Western%20Core%20Terms:Procedures%3A+Bone+Marrow+T
Transcript: NORA ALESSI BONE MARROW EXAMINATION Bone Marrow DEFINETION 1)Bone marrow biopsy 2)Bone marrow aspiration 3) clot section 4)biopsy imprint smears BONE MARROW TEST BONE MARROW TEST BIOPSY INDICATIONS OF BONE MARROW BIOPSY: ASPIRATION INDICATIONS OF BONE MARROW ASPIRATION IMPORTANCE OF CLOT SECTION CLOT SECTION TOUCH IMPRENT IMPORTANCE OF TOUCH IMPARENT: COMPARISON COMPARISON ADVANTAGES ASPIRATION ADVANTAGES BIOPSY DRAWBACKS ASPIRATION: DRAWBACKS: BIOPSY: **** ***** SITE SITE ASPIRATION ASPIRATION BIOBSY BIOBSY NEEDLE TYPE OF NEEDLE Name, Department Start date Name, Department Start date Name, Department Start date Name, Department Start date Name, Department Start date TYPE OF NEEDLE COMPLICATION COMPLICATION: THANK YOU THANK YOU
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