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To progress further in drug development, DISEASE MARKERS are needed to:

(i) detect the disease early in its course

(ii) track neurodegeneration over time

Help &

training

Algorithm pipelines

for marker extraction

Computational

resources

(GRID/

Cloud/HPC)

Large

image

datasets

"GOOGLE" FOR BRAIN IMAGING

http://www.neugrid4you.eu

& GLOBIOS

Large public datasets +

computationally intensive algorithm pipelines =

Need for new environments for image analysis

- 150 core hours per scan

- 1TB resultset

==> Data Challenge = '000 scans

“Data sharing has been successfully implemented in initiatives in the biomedical field, such as the Alzheimer’s Disease Neuroimaging Initiative”

Large brain image datasets are now publicly available

Cortical thickness at month 12

Disease

markers

Difference M12 - M0

Cortical thickness at month 0

Sophisticated

algorithm

pipelines

"Tera" datasets

PRESENTATION AT EUDAT 1st Conference

October 23 2012

Treated

Untreated

European Science Gateway

to Neuroimaging

Giovanni B Frisoni

Neurologist & Dep Scientific Director

IRCCS Fatebenefratelli, The Nat Centre for Alzheimer's Disease

Brescia, IT

David Manset, DPhil

CEO gnúbila France

Annecy, FR

http://www.neugrid4you.eu