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Transcript

Okay, but where's Moby Dick?

Henrietta Lacks

(August 1, 1920 – October 4, 1951)

Do I contradict myself?

Very well then I contradict myself,

(I am large, I contain multitudes.)

- Whitman

An African-American woman who was the unwitting source of cells from a cervical cancer tumor, which were cultured by George Otto Gey to create an immortal cell line for medical research. This is now known as the HeLa cell line.

Acknowledgements:

  • Joanne Luciano, Deborah McGuinness, Tim Lebo, Jim Meyers - RPI
  • Michael Krauthammer - Yale
  • Ian Fore,

The Immortal Life of Henrietta Lacks (Rebecca Skloot)

(Thanks)

Some Gene Expression Data and Provenance for HeLA

Provenance is Everywhere!

Adverse Events

Functional Requirements for Bibliographic References (FRBR)

The Biospecimen Repository as Library: How HeLa is like Moby Dick

LIMS

Workflow

prov:specializationOf:

Jim McCusker

Tetherless World Constellation, Rensselaer Polytechnic Institute

Krauthammer Lab,

Yale School of Medicine

Functional Requirements for Information Resources (FRIR)

A link between more and less abstract forms of the same thing

MAGE-TAB

Biospecimens

The Ship of Theseus

Rivers

Hurricanes

"The ship wherein Theseus and the youth of Athens returned [from Crete] had thirty oars, and was preserved by the Athenians down even to the time of Demetrius Phalereus, for they took away the old planks as they decayed, putting in new and stronger timber in their place, insomuch that this ship became a standing example among the philosophers, for the logical question of things that grow; one side holding that the ship remained the same, and the other contending that it was not the same."

Organisms

Businesses

Computers

Cars

So What?

Bands and Orchestras

http://en.wikipedia.org/wiki/Ship_of_Theseus

Institutions

Sports Teams

More simply:

We're talking about the same thing, but within broader and narrower contexts

As the proverb says: “This is my grandfather’s axe: my father fitted it with a new stock, and I have fitted it with a new head.”

Abstraction is a form of contextualization.

—Robert Graves, The Golden Fleece, p. 445

This happens when you model change in any monotonic system.

What does it mean when something is the same, even when it's changed?

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