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Internal Structure of Skeletal Muscle

Whole Skeletal Muscle -> Fascicles -> Muscle Cell (Fiber) -> Myofibril -> Myofilaments

Fascicle:

  • Made of connective tissue
  • Surrounds individual muscle cells
  • Electrically insulates each muscle cell from each other

Endomysium, Perimysium, & Epimysium:

  • Three connective tissues
  • Bind muscle cells together
  • Provide supports and strength for the entire muscle
  • Continuous with tendons at the end of the muscle

Terminal Cisternae

Sarcolemma

I Band (Light)

A Band (Dark)

Nucleus

Triad

T Tubule

Sarcoplasmic

Reticulum (SR)

H Zone

Muscle (Fiber) Cell

Nucleus

Myofibril

Fascicle

Thin Filament

(Actin)

Perimysium

Muscle

(Fiber)

Cell

Fascicle

Thick Filament

(Myosin)

Endomysium

Mitochondrion

Perimysium

Cytosol

Tendon

Epimysium

Z Line

M Line

Z Line

Sarcomere

Cytosol: Fluid between cells

Tendons: Skeletal muscles are attached to bones by tendons

Mitochondria: Sites of ATP synthesis

Epimusium: The connective tissues surrounding the entire muslce

Myofibrils: Contractile units within muscle cells

  • Made of myofilaments called thin and thick filaments
  • Thin and thick filaments are made up of the proteins: actin and mysoin

Fascicles: Bundles of muscle cells

Myofibril: Contains contractile filament within the skeletal muscle cell

Perimysium: Connective tissue surrounding the fascicles

A Bands: Dark areas that correspond to the presence of thick filaments

Triad: A roup of one T tubule lying between two adjacent terminal cisternae

I Bands: Light areas that contain only thin filaments

Terminal Cisternae: Sac-like regions of SR that contain the calcium ions.

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H Zone: Found in the middle of each A band.

  • Lighter stripe appears that correspond to the region between thin filaments

T Tubules: Invaginations of the sarcolemma which project deep into the cell

Sarcoplasmic Reticulum (SR) - Interconnecting tubules of endoplasmic reticulum that surrond the myofibril

M Line: Protein fibers that connect to thick filaments

Sarcolemma: Plasma membrane of a muscle cell

Sarcomere: The region of the myofibril between two Z Lines

Nucleus: Contains the genetic material

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