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PCOS concept map
12
PCOS Pathophysiology :
Is PCOS a part of insulin resistance?
OBESITY
primary abnormal
physiologic changes
disturbed
feedbacks
GnRH releasing
frequency change
Insulin
Resistance
secondary
unknown
interactions
LH is more
than FSH
Hyper-
insulinemia
the third
FSH
down
LH up
-
+
LIVER
SHBG decreases
free androgen
increases
consequences and
symptoms
DM?
due to defects of
aromatase gene
theca cell
secretes more
androgen
granulosa cell
can't secertes
estrogens
Androgen
increase
Progestins
falls
Estrogen
falls
Hyper-androgenemia
estrogen not enough
for follicles growth
endometrial
protection
is decreased
androgen will transform into
estrone at peripheral tissues
and stimulates endometrium
polycystic ovaries
oligomenorrhea
anvoulation
infertility
hirsutism
acne
endometrial
carcinoma