The Past, The Present, The Future of Nanotechnology and Hyperthermia Treatment

The Past. The Present. The Future of Kanzius Radiofrequency Treatment

John Yang

Present Studies

Use of Media

• Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma
• Noninvasive Radiofrequency Field Destruction of Pancreatic Adenocarcinoma Xenografts Treated with Targeted Gold
• Nanoparticles Pancreatic carcinoma cells are susceptible to noninvasive radio frequency fields after treatment with targeted gold nanoparticles
• Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field

Future

The Present

The Past

Bibliography

• Alternative Cancer Treatment - Kanzius Cancer Research Foundation. (n.d.). Retrieved October 26, 012, from Alternative Cancer Treatment - Kanzius Cancer Research Foundation website: http://www.kanziuscancerresearch.org/ Self-heating nanoparticles as tumor-destroying hyperthermia agents. (2007, January 22). Retrieved October 28, 2012, from Nanotechnology Now website: http://www.nanotech-now.com/news.cgi?story_id=19851
• Cadet, J. (2009, April 30). Cancer to increase by 45 percent over the next 20 years. Retrieved October 26, 2012, from Healthy Imaging website: http://www.healthimaging.com/topics/oncology-imaging/cancer-increase-45-percent-over-next-20-years
• Cancer Future Predictions Article. (2009, May 4). Retrieved October 29, 2012, from LDN_4_Cancer website: http://health.groups.yahoo.com/group/LDN_4_cancer
• Gannon. (2007). Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer, 110(12), 2654-2665.
• Glazer, E. S., Massey, K. L., Zhu, C., & Curley, S. A. (2010). Pancreatic carcinoma cells are susceptible to noninvasive radio frequency fields after treatment with targeted gold nanoparticles. Surgery, 148(2), 319-324
• Glazer, E., Zhu, C., & Massey, K. (2010). Noninvasive Radiofrequency Field Destruction of Pancreatic Adenocarcinoma Xenografts Treated with Targeted Gold Nanoparticles. Clin Cancer Res, (16), 5712-5721.
• Kanzius, J. (2005). U.S. Patent No. US20050251233. Washington, DC: U.S. Patent and Trademark Office.
• Raoof, M., & Curley, S. A. (2011). Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma (2). International Journal of Hepatology, 2011, 1-6.
• Using Gold, Silver & Carbon Nano-Particles to find a Cure for Cancer. (n.d.). Retrieved October 30, 2012, from Free Bullion Investment Guide website: http://www.free-bullion-investment-guide.com/cure-for-cancer.html

2012

2005

Future Studies

Introduction

http://www.kanziuscancerresearch.org/about/our-mission

'

Hyperthermia

Initial Questions

• "What if I could make the cancer cells act like little radio receivers and pick up the signal?
• "Would they get hot once they pick up the signal and create fever?"

• RF absorption enhancer directly injected to targeted area
• aqueous solutions containing suspended particles
• electrically conductive material
• metals
• iron
• magnetic particles
• i.e. colloidal gold, single-walled carbon nanotubes
• antibodies or ligands attached
• RF signal is transmitted

Mechanism

• Kanzius took the idea to his oncologist at University of Texas MD. Anderson Cancer Center Dr. Steven A. Curley
• idea that gold or metallic particles into malignant cells and heat with radio waves
• Ideally, treatment does not have clinical side effects, while completely ablating malignant tissues.

Steps leading up

http://www.nanohealthalliance.org/events-2/past-events/events-1/nanoparticles-as-intracellular-targets-to-produce-rf-induced-thermal-destruction-of-cancer-cells/

http://www.pueschner.com/basics/phys_basics_en.php

• RF radiation is absorbed by matter
• molecules oscillate
• most effective with polar (i.e. water)
• rotation energy friction
• heating
• basis for microwave cooking

Kanzius Radiofrequency (RF) Hyperthermia Treatment

US Patent on System and Method For RF-Induced Hyperthermia

• Use of silver nanoparticles
• Human clinical trials
• Improving accuracy of targeting
• Implications or problems?

• Form of treatment with elevated temperature
• 41-45 degrees Celsius
• Least clinical side effects

• John S. Kanzius (1944-2009)
• American inventor
• No degree from college
• Radio/TV Engineer
• Cancer Patient
• non-Hodgkin lymphoma (blood cancer)
• includes any kind of lymphoma except Hodgkin's
• Motivation from personal experience with chemotherapy

Problems

• difficulties in controlling agent transport
• low heating temperature due to heat loss through space gap between the cells and hyperthermia agents
• Damages healthy cells

Funding

http://upload.wikimedia.org/wikipedia/en/a/a3/JohnKanzius2005Photo.PNG

http://www.wish.org/

• Should the Kanzius Research Foundation turn to ________ for funding?
• Government
• Celebrities
• Big Pharms
• Other

http://www.standup2cancer.org/