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High altitude physiology
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Transcript
High altitude physiology
Bohr and Haldane effect
Do you remember?...
Blood gas
transport
Bohr-haldane effect
Bohr effect
Oxygen–haemoglobin dissociation curve
Haldane effect
Carbon Dioxide Dissociation Curve
High altitude conditions
Pressure and Oxigen
AMB: Ambient
INSP: Inspired
ALV: Alveolus
ART: Arterial
2,3-DPG level will increase
Let's recap...
Blood gas transport
Bohr-Haldane effect
High altitude conditions
DPG
pH
Temp
DPG
}
{
Bohr effect
Thigh
}
CO2 delivered
Lungs
Bibliography
- Andrew J.Young, PhD.Human Adaptation to high terrestral altitude, Chapter 21.
https://ke.army.mil/bordeninstitute/published_volumes/harshEnv2/HE2ch21.pdf
- Sally Osborne, Ph.D.Blood gas transport. Department of Cellular & Physiological Sciences
http://www.sallyosborne.com/Med%20Lecture-%20Transport%20Of%20Blood%20Gases.pdf
- N.P Mason.The physiology og high altitude: an introduction to the cardio-respiratory changes ocurring on ascent to altitude.
http://www.ericjlee.com/Mountains/The%20Physiology%20of%20High%20Altitude.pdf
- Bohr Effect vs. Haldane Effect. khanacademymedicine
Sergi Fluvià Sabio
UPC-ESAB
Animal Physiology
Breath more
Respiratory Alkalosis
O2
Describes the fact that oxygen and carbon dioxide destabilize each other’s binding to hemoglobin.
We are at high altitude!
Shift the hemoglobin dissociation curve to the left
Hb can pick up O2 easier
Stimulation of peripheral chemoreceptors
CO2
Return to normal pH
Hypoxia decreased dissolved oxygen in the blood
CO2/H+ are affecting the affinity of Hb for 02
O2 is affecting the affinity of Hb for CO2/H+
Right shifted Hb curve
Easier O2 delivery to their muscles during competition
High altitude conditions
Why athletes go to the mountain before a competition?
Shift the Hb curve to the right
Making O2 delivery easier to tissues
}
Haldane effect
Lungs
}
O2 delivered
Thigh
Bohr effect
Haldane effect
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