cancer y emociones

Dr. Joan Vidal-Jové

• Responsable del Programa HIFU en Cirugía Oncológica con Ultrasonidos de Alta Energía, Hospital Universitario Mutua Terrassa, Pza. Dr. Robert, 5, 08221 Terrassa, +34937365050, ext. 1597 http://www.clinicamutuaterrassa.com/ca/oferta-serveis-de-salut/especialitats/unitat-hifu

• Director del Institut de Medicina Biorreguladora Barcelona, c/ Bruc 99, 2-1, 08009, Barcelona. Tel. +34934579239. www.vidal-jove.net

• Director de Khuab Barcelona, Innovación en Oncología, Hibridación y Salud, Barcelona. Tel. +34628745096. www.khuab.com

Metodología

OPERATIVA

TRATAMIENTOS CONVENCIONALES

CIRUGIA, QUIMIOTERAPIA, RADIOTERAPIA

HIPEROXIGENACIÓN TISULAR HIPERTERMIA

CIRUGIA NO INVASIVA

ABLACIÓN POR ULTRASONIDOS-HIFU

CIRUGIA INMUNOLÓGICA: STEM CELLS, CÉLULAS DENDRÍTICAS, G-CSF

BELJANSKI-IFIGEN

MEDICINA BIORREGULADORA

BIORRESONANCIA

BIOPUNTURA

EMDR

EFT

TAPPING

MBSR (MINDFULLNES)

HQI

RESPIRACIÓN ESENCIAL

DIMENSIÓN

FISICA :

CONCRETA

• LA ENFERMEDAD EN EL ÓRGANO Y SUS SÍNTOMAS ASOCIADOS

SISTEMAS

• INMUNIDAD
• INFLAMACIÓN
• NEUROVEGETATIVO
• MUCOSAS
• CONJUNTIVO
• CIRCULATORIO

MENTAL-EMOCIONAL:

• ESTRES Y CONFLICTOS EMOCIONALES PREVIOS
• EL DIAGNÓSTICO
• MIEDO
• INCERTIDUMBRE

ESENCIAL:

• VALORES FUNDAMENTALES PERSONALES
• ESPIRITUALIDAD
• PRIORIZACIÓN
• QUIÉN SOY Y QUE QUIERO

Hanahan D, Weinberg RA. The hallmarks of cancer.

Cell. 2000 Jan 7;100(1):57-70.

LAS SEÑAS DE IDENTIDAD DEL cáncer +1

inmunidad - oncología - hibridación

6

cáncer y conflictos emocionales

relato de una cierta evidencia

SEÑAS DE IDENTIDAD DEL CÁNCER

• Mantenimiento de las señales de proliferación
• Desregulación de la energía celular
• Resistencia a la apoptosis celular
• Inestabilidad genómica y mutación
• Inducción de angiogénesis
• Activación de mecanismos de invasión y metástasis
• Entorno pro-inflamatorio
• Activación de replicación inmortal
• Evitación de destrucción inmune
• Evasión de supresores del crecimiento

• PubMed Results
• 1. Effect of gender and menstrual cycle on immune system response to acute mental stress: apoptosis as a mediator. Pehlivanoglu B, Bayrak S, Gurel EI, Balkanci ZD. Neuroimmunomodulation. 2012;19(1):25-32. Epub 2011 Nov 7.
• 2. Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. Surtees PG, Wainwright NW, Pooley KA, Luben RN, Khaw KT, Easton DF, Dunning AM. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1152-62. Epub 2011 Jul 25.
• 3. Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men. Nater UM, Whistler T, Lonergan W, Mletzko T, Vernon SD, Heim C. Biol Psychol. 2009 Oct;82(2):125-32. Epub 2009 Jul 3.
• 4. Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Flint MS, Baum A, Chambers WH, Jenkins FJ. Psychoneuroendocrinology. 2007 Jun;32(5):470-9. Epub 2007 Apr24.
• 5. Wound site neutrophil transcriptome in response to psychological stress in young men. Roy S, Khanna S, Yeh PE, Rink C, Malarkey WB, Kiecolt-Glaser J, Laskowski B, Glaser R, Sen CK. Gene Expr. 2005;12(4-6):273-87.
• 6. Stress-induced modulation of skin immune function: two types of antigen-presenting cells in the epidermis are differentially regulated by chronic stress. Nakano Y. Br J Dermatol. 2004 Jul;151(1):50-64.
• 7. Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity of CD4+ and CD8+ T cells by D1 dopamine receptors: an in vitro analysis. Saha B, Mondal AC, Basu S, Dasgupta PS. Int Immunopharmacol. 2001 Jul;1(7):1363-74.
• 8. Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults. Marsland AL, Cohen S, Rabin BS, Manuck SB. Health Psychol. 2001 Jan;20(1):4-11.
• 9. Social stress, dominance and blood cellular immunity. Stefanski V, Engler H. J Neuroimmunol. 1999 Feb 1;94(1-2):144-52.

características de un conflicto emocional "relevante"

• impacto agudo
• dramático e inesperado
• vivido en soledad
• no expresado

OXFORD CRITERIA

• OXFORD CRITERIA AND SCOTTISH SIGN

Therapy/Prevention/Etiology/Harm:

1a Systematic reviews (with homogeneity) of randomized controlled trials

1b Individual randomized controlled trials (with narrow confidence interval)

1c  All or none randomized controlled trials

2a  Systematic reviews (with homogeneity) of cohort studies

2b Individual cohort study or low quality randomized controlled trials (e.g. <80% follow-up)

2c  "Outcomes" Research; ecological studies

3a  Systematic review (with homogeneity) of case-control studies

3b  Individual case-control study

4  Case-series (and poor quality cohort and case-control studies)

5 Expert opinion without explicit critical appraisal, or based on physiology, bench research or "first principles"

levels of evidence

From the Centre for Evidence-Based Medicine, Oxford

For the most up-to-date levels of evidence, see www.cebm.net/?o=1025

SCOTTISH “SIGN”

Level of evidence Type of evidence

1++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias

1+ Well-conducted meta-analyses, systematic reviews of RCTs, or RCTs with a low risk of bias

1– Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias*

2++ High-quality systematic reviews of case–control or cohort studies High-quality case–control or cohort studies with a very low risk of confounding, bias or chance and a high probability that the relationship is causal

2+ Well-conducted case–control or cohort studies with a low risk of confounding, bias or chance and a moderate probability that the relationship is causal

2– Case–control or cohort studies with a high risk of confounding bias, or chance and a significant risk that the relationship is not causal*

3 Non-analytic studies (for example, case reports, case series)

4 Expert opinion, formal consensus

*Studies with a level of evidence ‘–‘ should not be used as a basis for making a recommendation (see section 7.4)

SIGN Levels of evidence for intervention studies. Reproduced with permission from the Scottish Intercollegiate Guidelines Network (SIGN); for further information, see ‘Further reading’