Immune Continued

Origin and Development of Adaptive Immunity

• Stem cells:
• Red bone marrow
• Give rise to all blood cells
• Give rise to some pre T cells and pre B cells

Eosinophils:

• Produced in red bone marrow
• Release chemicals to reduce inflammation

Innate Cells

Mast cells:

T cells:

• Made in red bone marrow
• Found in skin, lungs, gastrointestinal tract, urogenital tract
• Can release leukotrienes

• White blood cells:produce in red bone marrow and lymphatic tissue that fight foreign substances
• Phagocytic cells:
• Ingest and destroy foreign substances
• Ex. neutrophils and macrophages
• Neutrophils:first to respond to infection but die quickly

• Type of lymphocyte
• Involved in cell-mediated immunity primarily and antibody-mediated immunity
• Mature in thymus gland
• Move to lymphatic tissue after mature
• 4 types
• Killer T Cells
• Helper T Cells
• Memory T Cells
• Suppressor T Cells

B cells:

Macrophages:

• Type of lymphocytes
• Involved in antibody-mediated immunity
• Originate from stem cells
• Mature in red bone marrow
• Move to lymphatic tissue after mature
• Lead to production of antibodies

• Monocytes
• Leave blood and enter tissues
• Can ingest more than neutrophils
• Protect lymph in lymph nodes and blood in spleen and liver
• Given specific names for certain areas of body (Kupffer cells in liver)

Lymphocytes:

Basophils:

• Type of white blood cell
• Involved in adaptive immunity
• Develop from stem cells
• Differentiate into specific lymphocytes such as B or T cells

• Made in red bone marrow
• Leave blood and enter infected tissues
• Can release histamine

Immune Cells