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Electronic Aspirin

What Causes Cluster Headaches?

SPG Stimulation Therapy

Autonomic Technologies, Inc.

ATI is a medical device company focused on the development and commercialization of innovative therapies for the treatment of severe headache.

The company’s initial product, the ATI Neurostimulation System, is approved in Europe for the treatment of cluster headache and is currently being investigated in a multi-center, randomized study for the treatment of high frequency, high disability migraine.

Pathway M-1 Migraine Study

The European Pathway M-1 study is a multi-center, randomized clinical study to evaluate the safety and efficacy of the investigational ATI™ Neurostimulation System for the treatment of high frequency, high disability migraine. The study will being in Denmark, Belgium, Spain, France and Germany and hopefully expand from there.

Statistics:

1/1000 people suffer from cluster headaches

After using Electronic Aspirin:

  • 68% patients reported improvement (less pain or fewer headaches)
  • Average headaches per week decreased by 31%
  • 43% patients saw 88% decrease in headaches
  • 75% patients reported improvement in quality of life

Cluster Headaches

Electronic Aspirin consists of a small implant near the SPG nerve bundle along with a hand-held remote that is used at the patients' discretion when feeling the onset of a cluster headache in order to block the pain.

Common Treatments for Cluster Headaches

Transnasal Technique

This technique attempts to drip anesthetic

down the Q-tip that is inserted through the

naval passage. This approach takes 25-45

minutes and is rarely successful due to

the inaccuracy of the application.

Lateral Approach

This approach attempts to access the SPG nerve bundle by inserting a needle through the jaw joint to administer the medicine. This technique is mildly painful and dangerous with a low success rate due to inaccuracy.

Greater Palantine Forman Technique

This technique attempts to reach the SPG nerve bundle by inserting a needle through the roof of the mouth in order to deliver medicine. This approach is very painful and dangerous.

How Electronic Aspirin Works

Implant

Remote

• Implanted through upper gum near molars

• Side where headaches most often occur

• Patient uses remote controller up to cheek where implanted

• Patient can turn on and off as needed

• Can be left in place or taken out when no longer necessary

Works Cited

"Cluster Headaches Symptoms, Causes, Treatments -

MedicineNet." MedicineNet. N.p., n.d. Web. 08 Oct. 2013. <http://www.medicinenet.com/cluster_headaches/article.htm>.

Kinai, A., A. Suzuki, M. Kobayashi, and S. Hoka. "Intranasal

Lidocaine 8% Spray for Second-division Trigeminal Neuralgia." British Journal of Anaesthesia (2006): n. pag. Oxford Journals. 1 Aug. 2006. Web

A, A. D., M. "Cluster Headache." The New York Times [New

York] 17 Dec. 2012: n. pag. Print.

"Cluster Headaches." Autonomic Technologies. Autonomic

Technologies Inc., 2013. Web. 10 Sept. 2013.

"SPG Nerve Block." MiRx Blog. MiRx™ Protocol, 2013. Web. 01

Oct. 2013.

<http://www.mirxprotocol.com/mirx-protocol/spg-nerve-block.html>.

  • Unsure of the exact problem
  • Abnormalities in hypothalamus:

-Homeostasis

-Pituitary Gland

  • Activation of trigeminal nerve

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