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Copy of Nanotechnology for Treatment and Diagnosis of Cancer

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Omar Badran

on 23 June 2013

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Transcript of Copy of Nanotechnology for Treatment and Diagnosis of Cancer

Nanoparticles often possess unexpected optical properties as they are small enough to confine their electrons and produce quantum effects. For example gold nanoparticles appear deep red to black in solution. Nanoparticles of usually yellow gold and gray silicon are red in color. Gold nanoparticles melt at much lower temperatures (~300 °C for 2.5 nm size) than the gold slabs (1064 °C);.[22] And absorption of solar radiation in photovoltaic cells is much higher in materials composed of nanoparticles than it is in thin films of continuous sheets of material.
i.e. The smaller the particles, the greater the solar absorption.

Cell
Treatments
Surgery

Radiation

Chemotherapy

Hormonal
Treatments

Antibodies

Biological Response
Modifiers

Vaccines

Complementary
&
Alternative Medicines
Buckyballs
Liquid
Nanoshells
Also referred to as core-shells, nanoshells are spherical cores of a particular compound surrounded by a shell or outer coating of another, which is a few nanometers thick.
Diagnosis
REAtMEN
Nanoparticles containing drug molecules called interleukins are attached to immune cells ( T-cells)
NANOSHELLS are targeted to cancer cells for use in the molecular imaging of a malignant lesion
Also referred to as core-shells, Nanoshells are spherical cores of a particular compound surrounded by a shell or outer coating of another, which is a few nanometers thick.
technology Applications
in Treatment Diagnosis
Liposomes
Quantum
paramagnetic
end
rods
Both members of the fullerene structural class, buckyballs and carbon tubes are carbon based, lattice-like, potentially porous molecules.
Liquid crystal pharmaceuticals are composed of organic liquid crystal materials that mimic naturally-occuring biomolecules like proteins or lipids. They are considered a very safe method for drug delivery and can target specific areas of the body where tissues are inflammed, or where tumors are found.
Also referred to as core-shells, nanoshells are spherical cores of a particular compound surrounded by a shell or outer coating of another, which is a few nanometers thick.
Liposomes are lipid-based liquid crystals, used extensively in the pharmaceutical and cosmetic industries because of their capacity for breaking down inside cells once their delivery function has been met.

Liposomes were the first engineered nanoparticles used for drug delivery but problems such as their propensity to fuse together in aqueous environments and release their payload, have lead to replacement, or stabilization using newer alternative nanoparticles.
Also known as nanocrystals!

Quantum dots are nanosized semiconductors that, depending on their size, can emit light in all colours of the rainbow.

They have been applied in biotechnology for cell labelling and imaging, particularly in cancer imaging studies.
Superparamagnetic molecules are those that are attracted to a magnetic field but do not retain residual magnetism after the field is removed.

Targeted delivery of drugs, bioactive molecules or DNA vectors is dependent on the application of an external magnetic force that accelerates and directs their progress towards the target tissue.

They are also useful as MRI contrast agents.
Dendrimers are highly branched structures gaining wide use in nanomedicine because of the multiple molecular "hooks" on their surfaces that can be used to attach cell-identification tags, fluorescent dyes, enzymes and other molecules.

The first dendritic molecules were produced around 1980, but interest in them has blossomed more recently as biotechnological uses are discovered.
Typically 1-100 nm in length, nanorods are most often made from semiconducting materials and used in nanomedicine as imaging and contrast agents.

Nanorods can be made by generating small cylinders of silicon, gold or inorganic phosphate, among other materials.
Why
Iron oxide nanoparticles can be used to improve MRI images of cancer tumors.
Sensors based upon nanoparticles or nanowires can detect proteins related to specific types of cancer cells in blood samples.
Targeted heat therapy to destroy breast cancer tumors.

X-ray therapy may be able to destroy cancer tumors using a nanoparticle called nbtxr3.

One nanoparticle to deliver the chemotherapy drug and a separate nanoparticle to guide the drug carrier to the tumor.
PRESENTED BY
“Going for
Advances”
Building Nanotechnology labs
Conducting
more research
Holding more international
conferences to bring latest information
Final
Thank You
BIG
small
Sarah Mohamed Sherif
!
nano
&
of
Cancer
cancer
Cancer
1
2
3
4
5
6
7
8
9
Targeted
Therapy
?
?
Nanoparticles [Ultrafine particles sized between 100 and 1 nm]
are of great scientific interest as they are effectively a bridge between bulk materials and atomic or molecular structures. A bulk material should have constant physical properties regardless of its size, but at the nano-scale size dependent properties are often observed. Thus, the properties of materials change as their size approaches the nanoscale and as the percentage of atoms at the surface of a material becomes significant. For bulk materials larger than one micrometer (or micron), the percentage of atoms at the surface is insignificant in relation to the number of atoms in the bulk of the material. The interesting and sometimes unexpected properties of nanoparticles are therefore largely due to the large surface area of the material, which dominates the contributions made by the small bulk of the material.
&
Carbon Tubes
C r y s t a l s
Dots
SUPER
n a n o p a r t i c l e s
D
nano
rimers
nano
CANCER
f
?
o
r
capable of...
Eradicating

Monitoring
Targeting
cancer cells
tumors
all at the same time
&
treatment
responses...
t
t
Targeted chemotherapy that delivers a tumor-killing agent called tumor necrosis factor alpha ( αTNF) to cancer tumors. 

Polymer nanoparticles that carry the chemotherapy drug called docetaxel.

AuroShell™
Magnetic nanoparticles
Gold nanoparticles

Gold nanoparticles to deliver platinum to cancer tumors

Using polymer nanoparticles to deliver a molecule called JSI-124 to cancer tumors
ECOMMENDATION
R
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