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Transcript of Neural Pathophysiology
Photo by Kathy Aney of E.O.
Primary Injury Often
Followed by Secondary Injury
Signs & Symptoms
Depend Upon Many Factors
Limited Room Inside the Skull
Principles of Neural Pathophysiology
NRS 322 Pathophysiology II
1. Limited room inside the skull
Signs & symptoms
depend upon many factors
is often followed by a
1. Decreased LOC
2. CNS Infections
3. Spinal Cord
4. Peripheral Neuropathies
Karen goes home!
Three components inside the skull:
1. Brain tissue = 80%
2. Blood = 10%
3. Cerebrospinal fluid (CSF) = 10%
Produced @ 20 mL/hr
CO2 = potent vasodilator!
< 15 mmHg
> 20 mmHg
CPP = MAP - ICP
CPP goal = 60-70
< 60 mmHg
Karen sings the National Anthem at Round-Up
MAP = SBP + 2 (DBP)
e.g., Location of alteration
Ischemic Injury to Neurons
Spinal Cord & Peripheral Neurons
Burchum & Rosenthal (2016).
Lehne's pharmacology for nursing care
(9th ed.). St. Louis, MO: Saunders Elsevier.
Copstead, L. & Banasik, J. (2014).
(5th ed.). St. Louis, MO: Elsevier.
Felver, L. (2013). Online Materials:
PROP- Pathophysiology online.
Retrieved from https://evolve.elsevier.com/
Giddens, J. (2017).
Concepts for nursing practice
(2nd ed.). St. Louis, MO: Elsevier Mosby.
YouTube videos embedded on some slides.
2. Cerebrovascular Disease
3. Parkinson's Disease
4. Seizure Disorders
& Spinal Cord
1. Multiple Sclerosis
of axons in the CNS, both brain and spinal cord
Multiple areas of scarring -
1. Spinal Cord Injury - SCI
2. Amyotrophic Lateral Sclerosis - ALS
TIA versus Stroke
Loss of involuntary motor coordination
Amyotrophic Lateral Sclerosis
SCI - Autonomic Dysreflexia
Damage to Extremities from Meningococcal Bacteria
- Inflammation of the Meninges
- Inflammation of the Brain
Herpes simplex virus - HSV
Attacks the limbic system of the brain
Effects of stroke damage by hemisphere