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Why Do Some People Respond to Drugs Differently than Others?

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Susan Zepeda

on 19 November 2013

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Transcript of Why Do Some People Respond to Drugs Differently than Others?

Why Do Some People Respond to Drugs Differently than Others?
why do people get affected by drugs differently from others.
From 2005 to 2008, 48% of everyone in the U.S. was using at least one prescription drug, and 21% of people were taking three or more drugs. People are prescribed drugs all the time, but prescriptions can be dangerous because people can have different responses to drugs. These responses largely have to do with genetic mutations. Why are some genetic mutations associated with a different response to a drug? In this science project, you will explore an online drug and genetics database to identify how a genetic mutation can be associated with how a person's body processes, and responds to, a certain drug.
gene in human body.
Every gene in the human body consists of DNA (deoxyribonucleic acid). DNA is a genetic code that is made up of four different types of nucleotides: adenine (A), thymine (T), guanine (G), and cytosine (C). This DNA code is turned into mRNA (messenger ribonucleic acid) in our bodies in a process called transcription. In mRNA, a nucleotide called uracil substitutes for every thymine. But transcription is a bit more complicated than that. In transcription, DNA is initially turned into pre-mRNA, and in order to turn this into the final mRNA code, a process called splicing removes certain pieces of the pre-mRNA. Specifically, splicing removes pieces called introns, while other pieces called exons are left in and reassembled, becoming part of the final mRNA code.
The responses that different people have to drugs is different from each ither depending on the persons genes & hiw much of the drug they consume.
Human Genome, Chromosome, and Genes.
Determine why some gene mutations cause people to respond differently to a drug.
This is a space-filling model of the drug clopidogrel, the basic chemical structucture. In the model shown here, green is chlorine (Cl), red is oxygen (O), blue is nitrogen (N), and yellow is sulfur (S).
Susan Zepeda
Mr. Ardelean
If different types of people have different types of effects to drugs is do to gene mutations in the person which can cause side effect which usually is regarded as an undesirable secondary effect which occurs in addition to the desired therapeutic effect of a drug or medication then Side effects may vary for each individual depending on the person's disease state, age, weight, gender, ethnicity and general health.
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