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Late sodium current block for drug-induced Long-QT syndrome:
Transcript of Late sodium current block for drug-induced Long-QT syndrome:
Dofetilide is a strong hERG blocker with known Torsades risk
Mexiletine and Lidocaine both block the late sodium current.
What is the difference between safe QTc prolongation and dangerous QTc prolongation?
Can combining late sodium blockers with hERG blockers reverse pro-arrhythmic effects?