Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

yyyyyyyyy

No description
by

Azza Abd Ellateef

on 6 May 2014

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of yyyyyyyyy

DRUG DRUG INTERACTIONS
Because infliximab may reduce the response of the immune system, it should not be administered with
vaccines
containing live bacteria or viruses.
Alcohol Health Risks
• Since Remicade is often used to manage symptoms of autoimmune disorder, it is important to be aware of the potential effects of alcohol on the immune system.
Pharmacokinetics
PHARMACOLOGICL MECHANISMS
Infliximab is an antibody that attaches to a protein called tumor necrosis factor-alpha (TNF-alpha).
GENERIC NAME:
infliximab


BRAND NAME:

Remicade
Special Populations

Infliximab, an antibody to TNF-alpha .

produced by
the immune system of mice after the mice are injected with human TNF-alpha.

The mouse antibody then is modified to make it look more like a human antibody, and this modified antibody is infliximab.
Such
modifications
are necessary to decrease the likelihood of allergic reactions when the antibody is administered to humans.
Headache, stomach pain, or nausea may occur.

If these effects persist or worsen, tell your doctor or pharmacist promptly.
Infliximab
PREPARATIONS:
Powder for intravenous injection, 100 mg


STORAGE:
refrigerated at 2-8 C (36-46 F)

Absorption
Single IV infusions show a linear relationship between the dose administered and the C max .

Distribution :
Distributed primarily within the vascular compartment.

Elimination :
The half-life is 7.7 to 9.5 days
Renal Function Impairment شHepatic Function Impairment
It is not known if there are differences in Cl in patients with marked hepatic or renal impairment.

Elderly , Gender and weight
No major differences in Cl were observed in subgroups defined.

Children
Peak and trough concentrations were similar in children 6 to 17 age and adults with Crohn disease.


one of the proteins produced by immune cells during activation of the immune system.
TNF-alpha
TNF-alpha, in turn, stimulates other cells of the immune system to produce and release other proteins that promote inflammation.

In Crohn's disease, there is continued production of TNF-alpha as part of the immune activation.
Infliximab, by attaching to TNF-alpha, blocks its activity and in so doing decreases the inflammation.
reduces the signs and symptoms of inflammation but not cure Crohn's disease

can retard the destruction of joints by rheumatoid arthritis.

Combining infliximab with
drugs that also reduce the response of the immune system
, may increase the risk of serious infections.
In patients suffering from autoimmune disorders, alcohol can make the ‘problem’
Alcohol may suppress the body’s ability to detect and respond to infection. In one clinical study, it showed that alcohol can likely reduce the formation of white blood cells which is essential in fighting infectious agents.
Are There Any Food Interactions?
• There are no known food interactions
PHARMACOLOGICAL INDICATION
PRESCRIBED FOR: Infliximab is approved for use alone or combined with methotrexate (Rheumatrex, Trexall) for treating moderate to severe
rheumatoid arthritisr.

Infliximab is used for reducing the signs and symptoms of inflammation in moderate to severe
Crohn's disease


Infliximab is helpful
plaque psoriasis
, and psoriatic arthritis.
It also has been found to be helpful in treating the inflammation of
uveitis
and
sarcoidosis
that is not responding to traditional therapies.
SIDE EFFECTS
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects
Tell your doctor immediately if you develop signs of infection while using this drug, such as: fever, chills, night sweats, persistent cough, persistent sore throat, trouble breathing, painful/frequent urination, unusual vaginal discharge, white patches in the mouth (oral thrush).
This drug may rarely cause serious (possibly fatal)
liver disease
.
Contraindications
Infliximab should not be used under the following circumstances:

untreated
chronic infection
, such as tuberculosis or hepatitis B/C

patients with moderate to severe
congestive heart failure

known
hypersensitivity to murine proteins
or any other component of the product.
Infliximab is administered intravenously.

The recommended dose is
**for moderate to severe active Crohn's disease in adult or pediatric patients.
_ a5 mg/kg infusion at 0, 2, and 6 weeks
then
5 mg/kg every 8 weeks
_Adults who initially responded then lost response may be treated with 10 mg/kg.
**for the treatment of moderately to severely active rheumatoid arthritis

_3 mg/kg at 0, 2, and 6 weeks
followed by
3 mg/kg every 8 weeks.
_Infliximab should be combined with methotrexate .
_ if response is incomplete, up to 10 mg/kg or treating every 4 weeks may be tried.


psoriatic arthritis, and plaque psoriasis are treated with a 5 mg/kg infusion at 0, 2, and 6 weeks and
then
5 mg/kg every 8 weeks.
**Ulcerative colitis
DOSING
immuno system condition affeected by
granulomus
:
type of tissues formed over healing tissues
Crohn's disease
,: is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus
plaque psoriasis
immune-mediated skin disease characterized by red, scaly patches,
Rheumatoid arthritis (RA)
is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints
Trade name
Pharmacologica action
pharmacokinetics
Drug _Drug interaction
Drug_Alchol interaction
Drug _food interaction
Side effects
Pharmcological indication
Dosing
Contrandication
Azmi Shreef
3271
Azza Abd Ellftah
3272
Azza Abd Ellateef
3273
Afaf Adel
3274
Ola Abd Ellkhalik
3275
Ola Abd Elhamed
3276
Alla Elden Ahmed
3277
Alla Amen
3278
Ali Hassan
3279
Ali Ashour
3280

presented by
Wikipedia
Rxlist
WebMD
References
Full transcript