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Because infliximab may reduce the response of the immune system, it should not be administered with
containing live bacteria or viruses.
Alcohol Health Risks
• Since Remicade is often used to manage symptoms of autoimmune disorder, it is important to be aware of the potential effects of alcohol on the immune system.
Infliximab is an antibody that attaches to a protein called tumor necrosis factor-alpha (TNF-alpha).
Infliximab, an antibody to TNF-alpha .
the immune system of mice after the mice are injected with human TNF-alpha.
The mouse antibody then is modified to make it look more like a human antibody, and this modified antibody is infliximab.
are necessary to decrease the likelihood of allergic reactions when the antibody is administered to humans.
Headache, stomach pain, or nausea may occur.
If these effects persist or worsen, tell your doctor or pharmacist promptly.
Powder for intravenous injection, 100 mg
refrigerated at 2-8 C (36-46 F)
Single IV infusions show a linear relationship between the dose administered and the C max .
Distributed primarily within the vascular compartment.
The half-life is 7.7 to 9.5 days
Renal Function Impairment شHepatic Function Impairment
It is not known if there are differences in Cl in patients with marked hepatic or renal impairment.
Elderly , Gender and weight
No major differences in Cl were observed in subgroups defined.
Peak and trough concentrations were similar in children 6 to 17 age and adults with Crohn disease.
one of the proteins produced by immune cells during activation of the immune system.
TNF-alpha, in turn, stimulates other cells of the immune system to produce and release other proteins that promote inflammation.
In Crohn's disease, there is continued production of TNF-alpha as part of the immune activation.
Infliximab, by attaching to TNF-alpha, blocks its activity and in so doing decreases the inflammation.
reduces the signs and symptoms of inflammation but not cure Crohn's disease
can retard the destruction of joints by rheumatoid arthritis.
Combining infliximab with
drugs that also reduce the response of the immune system
, may increase the risk of serious infections.
In patients suffering from autoimmune disorders, alcohol can make the ‘problem’
Alcohol may suppress the body’s ability to detect and respond to infection. In one clinical study, it showed that alcohol can likely reduce the formation of white blood cells which is essential in fighting infectious agents.
Are There Any Food Interactions?
• There are no known food interactions
PRESCRIBED FOR: Infliximab is approved for use alone or combined with methotrexate (Rheumatrex, Trexall) for treating moderate to severe
Infliximab is used for reducing the signs and symptoms of inflammation in moderate to severe
Infliximab is helpful
, and psoriatic arthritis.
It also has been found to be helpful in treating the inflammation of
that is not responding to traditional therapies.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects
Tell your doctor immediately if you develop signs of infection while using this drug, such as: fever, chills, night sweats, persistent cough, persistent sore throat, trouble breathing, painful/frequent urination, unusual vaginal discharge, white patches in the mouth (oral thrush).
This drug may rarely cause serious (possibly fatal)
Infliximab should not be used under the following circumstances:
, such as tuberculosis or hepatitis B/C
patients with moderate to severe
congestive heart failure
hypersensitivity to murine proteins
or any other component of the product.
Infliximab is administered intravenously.
The recommended dose is
**for moderate to severe active Crohn's disease in adult or pediatric patients.
_ a5 mg/kg infusion at 0, 2, and 6 weeks
5 mg/kg every 8 weeks
_Adults who initially responded then lost response may be treated with 10 mg/kg.
**for the treatment of moderately to severely active rheumatoid arthritis
_3 mg/kg at 0, 2, and 6 weeks
3 mg/kg every 8 weeks.
_Infliximab should be combined with methotrexate .
_ if response is incomplete, up to 10 mg/kg or treating every 4 weeks may be tried.
psoriatic arthritis, and plaque psoriasis are treated with a 5 mg/kg infusion at 0, 2, and 6 weeks and
5 mg/kg every 8 weeks.
immuno system condition affeected by
type of tissues formed over healing tissues
,: is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus
immune-mediated skin disease characterized by red, scaly patches,
Rheumatoid arthritis (RA)
is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints
Drug _Drug interaction
Drug _food interaction
Azza Abd Ellftah
Azza Abd Ellateef
Ola Abd Ellkhalik
Ola Abd Elhamed
Alla Elden Ahmed