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Lundbeck 1 v5 McCauley

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Raymond McCauley

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Transcript of Lundbeck 1 v5 McCauley

TALENs
Reading DNA
+1-650-776-4561
for your attention
Raymond McCauley
biochemistry
biophysics
electrical eng.
computer science
bioinformatics
nanotechnology
genetic engineering
DNA sequencing
personalized health
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
systems
biology
past:
Biotech Chair: Singularity U
Co-Founder: Playtpus Project
Co-Founder & Chief Architect: BioCurious
Principal: Exponential Biosciences

Current Research Areas:
Personal Genomics
Therapeutic Genetic Engineering
Low Cost Access to Biotech Tools
Cancer Dx and Treatment
Singularity
University
Raymond McCauley
@raymondmccauley
Thank you
Raymond McCauley
Digital Biology:
@raymondmccauley
+1-650-776-4561
Conflicts
Medicine
Agriculture
Energy & Manufacturing
Biotechnology =
1/3 of Global Economy
& Financial Interests
Anthrocyte
Deloitte
Exogen
Genomera
GLG
Illumina
Intellimed
Platypus Project
QIAGEN
Singularity University
Verinata
WellPoint
Marked with throughout presentation.
*
Caterpillar
Disruption
is never
Expected
Food
example: Okanagan Fruit Specialties
Not multinational, but family startup
Not implanted, but adjusted
Not labeled, but branded
Entire presentation copyright 2014 by Raymond McCauley
Disruption
Mother (Nature)
Biotech
or
is the
of all
2020
=
+
2001
=
ApE = A Plasmid Editor
Rise of the
Biotech
Garage
Inventor
bioprinter project
OpenPCR
$599 DNA Copy Machine
+
Industrial
Biology
Biohacking
Cow-Free
Milk & Cheese
Genetic
Engineering
Software Development
=
The
small
future
is
industrial microbiology
yeast = tiny factories
like microbreweries
gene prospecting
supply chain disruption
Microbiomes
Bacterial Reservoir
Eat ammonia
Eliminate smell
Crowd out
tinea pedis
Keep feet healthy
Practical Advice
Use antibiotics wisely
Eat like ancestors
Get a dog
Citizen Science
& Crowd-Sourced
Metagenomics
Microbiomes
Microbiome Roles
Digest food
Synthesize nutrients
Protect against disease
Mood, sleep, eating behavior
Partnership with Mayo Clinic, as of Oct 2014
inflammatory bowel diseases
metabolic disorders
colorectal cancer

Secret Clinical Trials, revealed Feb 2015
1. Avoid excess sugary foods
2. Good quality sleep
3. Meditation and relaxation
4. Eat fiber
5. Eat natural probiotic foods
6. Consider probiotic supplements
The Gut Microbiome,
Anxiety and Depression:
6 Steps to Take
by Peter Bongiorno, ND, LAc
November 8, 2014
Jessica
Richman,
CEO
microbiome hacking
& DIY fecal transplants
Phage
Technology
Use viruses to kill bacteria
Image credit: Bacteriophages and Biotechnology
http://www.pharmainfo.net/luckypharmacist/bacteriophages
Shaping the oral microbiota
through intimate kissing
Remco Kort, Martien Caspers, Astrid van de Graaf, Wim van Egmond, Bart Keijser and Guus Roeselers
...we investigated the effects of intimate kissing on the oral microbiota of 21 couples by self-administered questionnaires about their past kissing behavior and by the evaluation of tongue and salivary microbiota samples in a controlled kissing experiment...
"
"
brings up many questions...
2015
=
One More Thing...
from being in
an exponential business
Find an exponential trend,
then hitchhike
A prototype beats a plan
Product Development Process (PDP)
typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk
Nothing fades faster than last year's technology
2008
$500K
2012
$1
People
Teams
Interdisciplinary
Disruption
is never
Expected
Salim Ismail
Add a specialty
Be half of a team
Assemble a varied team
Find translators
Develop internal people
Innovation Lessons
Triple Major?
Design Your Own Major?
A hackerspace for biotech

First biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

Located in Sunnyvale, California

501c3 all-volunteer community lab, supported by monthly memberships and classes
BioCurious/FBI
Joint Conference on
Biohacking
June 12-16, 2012
How long until
genetic engineering
for
humans
?
ZFPs
TALENs
CRISPR/Cas9
$10000
$5000
$1000
Better, Cheaper, Faster
Genetic Engineering
*
The
future
is
coming
fast
Drag and Drop
Genetic Engineering
Transcription
Activator
Like
Effector
Nucleases
TALENs have modified genes in:
yeast
fruitfly
roundworm
cricket
zebrafish
frog
rat
pig
cow
thale cress
rice
silkworm
human somatic cells
pluripotent stem cells
Nature Reviews Molecular Cell Biology 14, 49-55 (January 2013)
http://www.brc.a-star.edu.sg/index.php?sectionID=12
hijacked from plant bacteria that genetically engineer their host plants
discovered by Bogdanove & Moscou, Iowa State University, in 2009
make double stranded breaks to knock-out and knock-in genes
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
extraído del mecanismo del sistema inmunológico procariótico
descubierto por Horvath y Barrangou, DuPont/Danisco, en 2010
inmunizar bacterias industriales
silenciamiento génico en células madre
CRISPRs
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
SLC30A8
Lean muscles
Extra-strong bones
Alzheimer’s-resistant/immune
HIV-resistant/immune
Lower coronary risk
Stomach flu resistant
Type 2 Diabetes
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville, and George M. Church
Science 15 February 2013

Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A. Marraffini, and Feng Zhang
Science 15 February 2013
Academically (for reference)...
Commerically...
$43 million Series A , Nov 2013
Flagship Ventures
Polaris Partners
Third Rock Ventures
Partners Innovation Fund
TALENs
CRISPRs
CRISPR/Cas9
is a toolkit for
Genes
and regulatory regions
Knock-out
Knock-in
Repair
Edit
cheap
highly targeted
improvable
bluebird bio
Editas Medicine
GenSight
Lysogene
Spark
uniQure BV
Voyager Therapeutics
and others
Genetic Engineering
Therapeutics
Companies
they work,
everywhere
Human
Infertility
Prenatal Genetic Dx
Mitochondrial Therapy
Germ-Line Therapy
Enhancement
- Disease Risk
+ Intelligence
+ Longevity
NOW
NEXT
genetic
engineering
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Puping Liang, et al, Guangdong Province Key Laboratory of Reproductive Medicine
Announced 22 April 2015
Attempted Beta-Thalassemia therapy
Used nonviable embryos
Found it hard to do - off target & chimerism
Too controversial for most journals
Francis Collins on funding
Announced First Human Embryos Edited by CRIPSR
Biology now falls under Moore's Law
DNA Sequencing Economics
Cost
DNA Sequencing Tech
3X ~ 5X

Computer Tech
1.5X ~ 2X
Your chance to try it...
Consumer access to research tool
"Recreational genomics"
Disease risk, carrier status, genealogy
DNA Sequencing
2018
2022
=
=
=
Source: National Human Genome Research Institute, Exponential Biosciences
Every Disease
is a
Rare Disease...
marginal cost,
market segmentation
& value-added services
1 human genome + interpretation
=
$3900

5 human genomes, raw data, in bulk
=
$3000

1 fast delivery human genome
= $5000

1 human exome
=
$400

1 point-of-care bacterial identification
= $20 - $100+

1 human "gene scan" (e.g., 23andMe)
=
$99
Illumina Custom OmniExpress+ BeadChip
Assays about 1,200,000 oligo sequences
DNA Scan
DNA Sequence
most interesting/best known
1.2 million bases
0.04%
almost all
3.2 billion bases
100%
DNA Microarrays
Reading DNA
What can you do about
being at risk for
an
unpreventable
disease?!?
It turns out, lots of things:

prevention - vitamins, avoid UV
testing - Amsler grid
new opthamologist
investigate clinical trials
support research
don't put off that trip to the Louvre...
Try it...
So What?
Two
Personal
Examples
When I first found out about
my AMD risk
it was
"
untreatable
" & "
incurable
"
but
Genentech

now has 2 treatments available
footnote
*
Rare Disease
is the
Long Tail
of human health...
2013
=
2007
=

Covers
Disease risk, carrier status, genealogy

What do
you
want to know?
Some of your info also applies to
family...

Privacy:
to share or not to share?
Do you want to be found by long-lost relatives?
In US,
Health insurance
protected by law

(GINA)
Life insurance, long-term disability is
not
Next Generation Sequencing
Next
14 Jan 2014
HiSeqX 10
$10M
20 000 genomes/year
$1000/genome, all in
NextSeq 500
$250K
1-10 genomes/day
Now
Reactive
Near Future
Medicine
How does it work?
What do you get?
Other applications
NIPT = Non-Invasive Prenatal Test
Has replaced Amniocentesis
Tests for chromosomal disorders
Finding Fetal DNA in blood: Data Problem
Biggest Drug Problem?
compliance
+
personalization
Rohan Coelho, Rexanto
packaging
&
sensors
NASDAQ: ILMN
Market Cap: 27.26 B
P/E: 66.42
dominates market
virtual monopoly
large cash reserves
purchase/license new dev

*
=
Predictive
The End of
Mammograms
Colonoscopies
circa 2018-2020
*
2015
=
DNA Sequencing
Reading DNA
Genetic Engineering
Writing DNA
Hacking DNA
Democratization
Access to Tools
Pharmacogenomics
More Accurate - Less Risk - Fraction of the Cost
blood sugar
blood chemistry
temperature, blood pressure, ECG
transplant rejection
heat attack, stroke early warning
untreatable
incurable
You can't buy ENIAC for a penny

But you
can
buy:
Decent Laptop, $800
An 100 hours of cloud computing, $130
Graphics workstation, $11000
Moore's Law
Decent Laptop, $800
An 100 hours of cloud computing, $130
Graphics workstation, $11000
BETTER
circa 2010
circa 2015
Today:
Stealth companies that contacted me
Life Is the New Black
advisor,
consultant,
investor
Do you
believe?
Synthetic Biology Explained
James Hudson/Bridge 8
Video
6 min 27 sec (partial)
Control of
cell differentiation
& growth
"Viruses as Apps"
New antibiotics
Dentistry
Deliver genetic medicines
Water purification
Food preservation
We are
everywhere
...
currently tracking
23 community labs
200+ individual labs
on 6 continents
50+ companies out of BioCurious
$129+ Million in follow-on funding
Startups & schools copying model
Worldwide biohackerspaces
Rise of the
Biotech
Garage
Inventor
most innovative
education company
in the world
Boston
Paris
San Diego
Seattle
Oakland
Portland
Manchester UK
Biologigaragen
Biospace
Victoria, Canada
Copenhagen
Switzerland
Brooklyn
Sao Paolo
San Francisco
Shenzhen
Tokyo
Bio
Garage
Baltimore
Syn
Bio
Brasil
Top
100
#4
We teach
is
old
and
new
Agriculture
=
Biotechnology
Makerspaces
as an educational model
leverage existing schools, industries
versus video-based internet education
retention
offshorability
interdisciplinary & soft skills
Medicine
most disrupted
industry
profession
institution
business model
information
assymetry
flips
short term
people live longer
chronic care costs higher
Hospitals
in current form
= old model
long term
people live longer
health costs drop
biotechs
versus
pharma
small
innovators
job creators
research, agility, talent +
large
incrementalists
force reduction
+ finance, sales, regulatory
supercentralized
decentralized
subsidized
concierge care, Uber for healthcare
specialization, med tourism
still need emergency rooms, chronic care
=
eldercare
trends
wearables & implantables
sensors
robotics
patient activism
crowd-sourced clinical trials
medium-term: robotics & telemedicine
biotechs
versus
pharma
small
innovators
job creators
research, agility, talent +
large
incrementalists
force reduction
+ finance, sales, regulatory
+
2001
=
+
+
Microbiomes
& Metagenomics
Peter DiLaura, CEO
Microbiome Roles
Digest food
Synthesize nutrients
Protect against disease
Mood, sleep, eating behavior
Partnership with Mayo Clinic, as of Oct 2014
inflammatory bowel diseases
metabolic disorders
colorectal cancer

Secret Clinical Trials, revealed Feb 2015
Cancer
DNA
Companies
adapted from Eric Topol
Hereditary Breast and Ovarian Cancer Testing
$250
$199
26 genes, 20 countries
19 genes, international
redneck
genetic
engineering
Lego
+ DNA Origami
= Nanotechnology
DNA
Origami
Solugen
peroxides
from CO2
with enzymes
20x cheaper
portable
SynBio NewCo
small
The
future
is
Industrial
Microbiology
bacteria
yeast
algae
Disruption
for
Oil, Gas & Coal?
microorganisms = factories
synthetic biology
industrial biology
industrial chemicals - food - agriculture biofuels - medical research
or
DNA = blueprints
new factories = exponential
global capacity
61.4B gal
per year by 2018
source: Lux Research, Sept 2015
KLM Biofuel Program
Sustainability & Corporate Responsibility
80% CO2 reduction
Expensive
but getting cheaper
2013: 6 X kerosene
2016: 3 X kerosene
Fully sustainable in 2050 (SkyNRG)
& portable
price & supply chain disruption
Feeding farmed salmon
with protein from methane
pasado:
asesor,
consultor,
inversor
&
adaptado de Eric Topol
Peter DiLaura, director ejecutivo
Funciones del microbioma
Digestión de alimentos
Síntesis de nutrientes
Protección contra enfermedades
Estado de ánimo, sueño, alimenticio
capacidad global
232,4B L
por año hasta 2018
fuente: Lux Research, sept 2015
Programa de biocombustible de KLM
Sustentabilidad y responsabilidad corporativa
80 % de reducción de CO2
Costoso,
pero cada vez más económico
2013: 6 veces querosene
2016: 3 veces querosene
Completamente sustentable en 2050 (SkyNRG)
peróxidos de CO2 con enzimas
20 veces más económico
portátil
¿Interrupción
petróleo, gas y carbón?
de
Control de diferenciación
y crecimiento celular
Origami de ADN
+
Origami de ADN
=
Nanotecnología
Alimentos
Ejemplo: Especialidades de frutas de Okanagan
No multinacional, pero inicio familiar
No implantado, pero ajustado
No etiquetado, pero con marca
Expresión genética
"dopaje genético"
EPO, producción de hematíes
Miostatina, inhibición del crecimiento muscular
VEGF, producción de vasos sanguíneos
IGF-1, incremento de masa muscular orientada
Anuncio de primeros embriones humanos editados por CRIPSR
Edición de genes mediados por CRISPR/Cas9 en zigotos tripronucleares humanos
Puping Liang, et al, Guangdong Province Laboratorio clave de medicina reproductiva
Anunciado el 22 de abril de 2015
Se intentó la terapia para beta talasemia
Se usaron embriones no viables
Se encontraron dificultades: desfase y quimerismo
Demasiado controversial para la mayoría de las publicaciones
Francis Collins sobre la financiación
Asociación con Mayo Clinic, a partir de oct 2014
enfermedades inflamatorias del intestino
trastornos metabólicos
cáncer colorrectal

Ensayos clínicos secretos, revelados en feb 2015
?
Tools
sugarcane
corn
biocombustibles
biofuels
Lego
classes...
Biohacking
Resources
for Students
bit.ly/kidbiohack
Raymond McCauley
raymondmccauley
on Google Hangouts
+1-650-776-4561
Raymond McCauley
raymondmccauley
on Google, LinkedIn & Twitter
+1-650-776-4561
ihackbiotech@gmail.com
DNA Sequencing
Reading DNA
Genetic Engineering
Writing DNA
Hacking DNA
Democratization
Access to Tools
Secuenciación de ADN
Interpretación del ADN
Escritura del ADN
Decodificación del ADN
Ingeniería genética
Democratización
Acceso a herramientas
I am a scientist
I experiment
Trying something new:
Two Languages
Old World
New World
Why Digital Biology?
Santiago Ramón y Cajal
From Madrid, Spain
Father of modern neuroscience
C. elegans
worm, 1 mm long
has 959 cells
302 are neurons
6393 synapses
OpenWorm.org
Building the world's first digital life form. Open source.
Alejandro Tocigl, CEO & co-founder
*
Zika
& gene drives
1906 Nobel Prize
Can digitally model and simulate the worm's nervous system
Soy científico
Hago experimentos
Intento cosas nuevas:
dos idiomas
First clinical study, for gastric cancer, with Hospital Clínico Universidad Católica de Chile
microRNA diagnostics in low resource settings
Targeting emerging economies
Initial work completed at BioCurious in 5 weeks
De Madrid, España
Padre de la neurociencia moderna
Premio Nobel de 1906
maíz
caña de azúcar
rapidly push
new DNA through
whole population
in the wild
www.facebook.com/BiohackingChile/
GMOs

3.0
Genetically Modified Organisms
better yield
better nutrition
better digestion
drought tolerance
saline soil tolerance
fungus resistance
virus resisitance
Creative Commons
Attribution-NonCommercial
4.0 International
Tecnología de secuenciación de ADN
3 veces ~ 5 veces

Tecnología informática
1,5 veces ~ 2 veces
Hoy, la biología está sometida a la Ley de Mooore
costo marginal,
segmentación del mercado
y servicios de valor agregado
Hoy:
1 genoma humano + identificación
=
$3900

5 genomas humanos, datos sin procesar, en forma masiva
=
$3000

1 genoma humano de entrega rápida
= $5000

1 exoma humano
=
$400

1 identificación bacteriana de punto de atención
= $20 - $100+

1 "análisis de genes" humanos (por ej., 23andMe)
=
$99
TALENs have modified genes in:
yeast
fruitfly
roundworm
cricket
zebrafish
frog
rat
pig
cow
thale cress
rice
silkworm
human somatic cells
pluripotent stem cells
Nature Reviews Molecular Cell Biology 14, 49-55 (January 2013)
Transcripción
Activador
Similar
Efector
Nucleasas
En grupos
Regularmente
Interposicionados
Cortos
Palindrómicos
Repetidos
extraído de bacterias de plantas que diseñan genéticamente sus plantas huésped
descubierto por Bogdanove y Moscou, Iowa State University, en 2009
realiza separaciones de cadenas dobles para eliminar o insertar genes
hijacked prokaryotic immune system mechanism
discovered by Horvath & Barrangou, DuPont/Danisco, in 2010
immunize industrial bacteria
gene silencing in stem cells
Academically (for reference)...
seguimiento actual de
23 laboratorios comunitarios
Más de 200 laboratorios individuales
en 6 continentes
*
Adapted from Stephen Larson and Matteo Cantarelli
Courtesy of Tim Busbice
Courtesy of OpenWorm
Courtesy of OpenWorm
Courtesy of Bio-Rad
microorganisms = factories
synthetic biology
industrial biology
industrial chemicals - food - agriculture biofuels - medical research
or
DNA = blueprints
new factories = exponential
& portable
price & supply chain disruption
Locus of Control:
Individuals, Parents, Doctors, Legislators
Widening the Economic Gap
Different Nations & Societies
= Diverse Approaches
Ethics, Laws and Policies
Overcoming
Fear of Other / Fear of Change
from Every SciFi Movie Ever
Liquid Biposies for Cancer
DNA Sequencing
DNA Microarrays
&
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
SLC30A8
Lean muscles
Extra-strong bones
Alzheimer’s-resistant/immune
HIV-resistant/immune
Lower coronary risk
Stomach flu resistant
Type 2 Diabetes
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
redneck
genetic
engineering
Expresión genética
"dopaje genético"
EPO, producción de hematíes
Miostatina, inhibición del crecimiento muscular
VEGF, producción de vasos sanguíneos
IGF-1, incremento de masa muscular orientada
Locus of Control:
Individuals, Parents, Doctors, Legislators
Widening the Economic Gap
Different Nations & Societies
= Diverse Approaches
Ethics, Laws and Policies
Overcoming
Fear of Other / Fear of Change / Every SciFi Movie Ever
LA Biohackers
TheL4B.com
Garage Labs
PCR Machine
Gel Electrophoresis
Fridge & Freezer
Water & Bleach

Biosafety Cabinet
Scale & pH Meter
Photospectrometer
basic equipment set
bicycles & woodworking optional
Cognitive
Genomics
+
Testing + Embryo Selection
+ Genetic Manipulation
environmental impact
food security
Making Leather and Meat Better
Trends: Disruption, Eco Foods, Food Security 3.0
Future of Food
good preview
of things to come
Biomimetics / Packaging
Nutrigenomics
environmental impact
food security
Hyperlocal Farming
Vertical Farming
hyperorganic, hyperlocal
pesticide & herbicide free
Fiesta Hypermart, Houston, Texas, 1991
10,000+ sq ft hydroponic produce dept
Houston's biggest tourist attraction
Backed by NASA CELSS research group
6 months
700 000 meals sold
$2+M revenues
biodegradable & delicious
protein-based packaging
Bob's, Brazil
just the beginning...
Making Leather and Meat Better
Courtesy Ruby Gadelrab, Invitae
Personalized & Functional Foods
Now, Near, Next
Trends: Urbanization, Food Security 3.0
Trends: DNA, Ubi-Sensors
Trends: Disruption, Eco Foods, Food Security 3.0
yogurt = finger food
WikiFood, WikiPearl
Dave Edwards, Harvard bioengineer
Trends: Eco Foods, Food Security 3.0
Livestock Genotyping
trait prediction
breed, pedigree, parentage
identification
outbreak traceability
Genus PLC
Jerry Thompson, COO
David Hunt,
Co-Founder
Trends: Big Data, Ubi-Sensors, Robotics, DNA, Microbiomics
Digitizing Agriculture
Laptop & Wifi
Biohazard Disposal
Centrifuge
Pipettors
Autoclave
Multimeter
3D Printer
getting fancy
Jane Doe
Female, 36, Non-smoker, BMI=19
Can't Deny Coverage?
Chilling effect on life-saving genetic testing
Can't Ignore Genetic Tests
Alzheimers, Familial Cancer High Risk,...
Personal Genetic Testing
Breaks
Insurance
Patient's finding long-term care issues
5X more likely to buy long-term policy
- Dr. Green, Brigham and Women's Hospital, Personal Communication
Legal backlash
Oregon, Vermont:
ban
genetics + life insurance
California, Texas, New York, US - next?
modeled on GINA and HIPAA
25% of test refusers:
fear life insurance discrimination
But BRCA1-positive:
~60% breast cancer risk
versus ~12% general risk
Insurance + Health Data Escrow
as Testing Providers
Allow Genetic Tests,
BUT
Hold Premiums Steady
Encourage clients to screen, take action
Preventive measures =
Risk drops from 87% to 5%
Down from circa $4000 from Myriad Genetics
LIfe Insurance Denied
Based on Genetic Testing
Legislators: Exempt
some
insurance companies
genspace.org
33 Flatbush Avenue, 7th Floor, Brooklyn, NY
Squaring the
Survival Curve
Cell
Repair
Technologies
Accidental death
by 190
on average
Hans Rosling's
Gapminder
Beyond 120?
Death is not a Democrat
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Genetic engineering
Stem cell therapy
Melanoma repair
DNA cross-checking
DNA repair
DNA
Cryonic recovery
Cell reprogramming
Death Be Not Proud, Part 3
Cryonics for
Organ Replacement
Organ Preservation Alliance
DNA
Nanobots
Stem
Cell Tx
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behavior Change
Underestimate Savings Need
Health Care Cost Increase
Active Retirements
Inheritance Decrease
Longevity Escape Velocity
+ 3.0 months / year
+ 2.5 months / year
http://rockhealth.com/tag/wearables/
"Cellular scissors chop up HIV virus"
Salk Institute
Nature Communications "Use of the CRISPR/​Cas9 system as an intracellular defense against HIV-1 infection in human cells", Liao et al
23andMe and Apple
enter drug research business
"crowd-sourced clinical trials"
Apple ResearchKit
- Asthma
- Parkinson's Disease
- Breast Cancer
- Diabetes
- Cardiovascular
Enrolled 7400+ people in 24 hours.
Previous largest study was 1700.
Life Expectancy +25

Deaths in ages 85-110
2000: ~50%
2030: ~10%
Death Be Not Proud, Part 2
Genome Project Dividend
Worldwide Infectious Disease
Extend Healthspan
cancer
cardiovascular disease
neurological conditions
Autoimmune, Affluence
Health Surveillance
Quantified Self
Biosensors
People who never got:
cancer
cardiovascular disease
neurological conditions
Q: Secret to live a long time?
A: Pick good parents!
Longevity
Limit at 120, for a while
Overpopulation? No
Proposal: Longevity Lab
Pensions & Advanced Health Accounts
It Varies, by Disease & Country
Longevity Lab
examples:
Alzheimer's Disease
Hereditary Breast and Ovarian Cancer (HBOC)
Sudden Cardiac Arrest (SCA)
Cardiomyopathy, Hypertension
FDA v. 23andMe
GINA regulations
Old World
New World
Why Digital Biology?
Santiago Ramón y Cajal
From Madrid, Spain
Father of modern neuroscience
C. elegans
worm, 1 mm long
has 959 cells
302 are neurons
6393 synapses
OpenWorm.org
Building the world's first digital life form. Open source.
1906 Nobel Prize
Can digitally model and simulate the worm's nervous system
*
Adapted from Stephen Larson and Matteo Cantarelli
Courtesy of Tim Busbice
Courtesy of OpenWorm
Courtesy of OpenWorm
Courtesy of Bio-Rad
Age of Discovery
My presentation
bit.ly/PeruGICbiotech
Mi presentación
Old World
New World
Mundo antiguo
Nuevo mundo
Edad de descubrimiento
Creative Commons
Attribution-NonCommercial
4.0 International
Indie.bio, 479 Jessie Street, San Francisco, CA
sf.indiebio.co
Fall 2016 Deadline for $250K seed funding, September 1!
Indie.bio, San Francisco
Counter Culture Labs, Oakland
Berkeley Biolabs, Berkeley
Janssen Labs + QB3, 953 & UCSF
Bay Area Biohackers
& Small Startup Labs
Miroculus
microRNA diagnostics
Breakthroughs in stomach cancer detection
New IP in digital microfluidics
Starting Series A fundraising
Singularity GSP 2014
Singularity U Companies
Miroculus
, microRNA diagnostics
ImpactVision
, multispectral food sensors and software
Morpheeo
, protein detection and measurement
Nutrigene
, universal nutrition
Migenoma
, genetic sequencing services for Latin America
Basepaws
, Consumer genomics for pets
*
Full DIsclosure: Advisor and investor
Raymond McCauley's
Companies
to
Watch
Tools
Invitrogen
QIAGEN
ThermoFisher
DNA Sequencing
Helix
Illumina
Oxford Nanopore
Veritas Genetics

Diagnostics
Grail
mirOculus
Myriad Genetics
Natera
Genomics
Athgene
Basepaws
Clear Labs
Color Genomics
Counsyl
Invitae
Orig3n
Seven Bridges
DNA Synthesis
DNA2.0
Molecular Assemblies
Twist
Health
HLI, Arivale
Foundation Medicine
Devices & Sensors
Biomeme
Chai Bio
FREDsense
Nanomedical Diagnostics
Scio
Food Sensors
Innit
ImpactVision

New Food
Mark Post
Nutrigene
Impossible Food
Perfect Day
v2016.9
Also: Pharma, Therapeutics, Stem Cells, Industrial Bio, Insurance, Medical Services, Accelerators, Other
The Great Demographics Shift
Population over 60
1900 9%
2000 20%
2020 25%
2050 >35%
World population, more developed regions
World Population Aging 1950-2050,
United Nations
http://www.un.org/esa/population/publications/worldageing19502050/pdf/81chapteriii.pdf
Accelerates with new health tech
Concentrates wealth
Affects immigration policy
*
buscando un bioinformático
Explosion of
consumer genomics
Impacts on Industry
Pharma
precision medicine,
now

= big data + sensors + genomics
(not core competencies)
Food
Fuel
Fiber
industrial biology,
5-10 yrs
supply chains decentralize & demonetize
labeling/transparency, GMOs 3.0,
ag biothreats, unstable commodities,
packaging, new sensors,
consumer "spytech", cellular agriculture
(and Consumer Products & Goods)
outcome-based reimbursement,
liquid biopsies, cheap monoclonal Dx & Tx,
stem cell Tx, universal genomics,
tissue culture Dx & Tx, emerging disease,
human genomic enhancement, longevity as TX class
(and Marketing)
(and personal health)
Fintech
Longevity
aging demographics,,
squaring the longevity curve,
paying for new therapies,
behavioral genomics
genomics breaks life insurance + annuities,
now
copyright, Raymond McCauley, +1-650-776-4561
as New Models
for Innovation
and Accelerators
Techshop
indie.bio
Hacker Dojo
Noisebridge
DARE2mansion
Hackteria
FabLab / HTGAA
Target CoLab
Janssen Labs
Silicon Valley
International
Corporate
National
Startup Chile
Hackerspaces
250+ companies
Ancestry
Athletic
Child talent
Matchmaking
Surreptitious
Non-legal paternity
Legal paternity
Nutrigenomics
Family
Carrier
Health testing
Microbiome
Pets
Food
The Last 100 Years
has seen an unprecedented increase in human survival and lifespan...
But can this trend continue?
Hans Rosling's Gapminder
source: 23andMe report for Raymond McCauley
GeneSight
30 genes for $29?
Pricing
Pharmacogenomics
Traditional Treatment
Personalized Treatment
+
Adapted from Genesis Genome
Pharmacogenomics
is the Killer App
for Genetic Testing
Why has adoption
been so slow?
cost to perform
billed at
about $30
typically $5000-$8000
Neuropsychiatric pharmacogenomic test
from Assurex Health
12 genes
55 meds
$150-$330 patient copay
billed at $500-$1200
pharmacogenomic panel
in bulk
Biodefense
Basis Biodefense Monitoring System
Cellular Agriculture
positives
fewer environmental impacts
safer, purer product
more consistent supply
no harm to animals
real world examples
beef with healthier fats
milk without lactose
eggs without cholesterol
rhino horn with no extinction
negatives
the "ick" factor
Uma Valeti
CEO & Co-founder
"We want to make
safe and healthy
meat for everyone
without
hurting animals."
Full transcript