Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Systemic Lupus Erythematosus

No description
by

Carmen Liu

on 20 February 2014

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Systemic Lupus Erythematosus

Anatomy and
Physiology
Treatment
Etiology
Lupus is an autoimmune disease
Many scientists believe that lupus develops in response to a combination of factors both inside and outside the body
Current Research
Sources
http://www.lupus.org/answers/entry/what-causes-lupus
http://www.lupus.org/answers/entry/how-is-lupus-treated
www.mollysfund.org
www.lupus.org
http://umm.edu/health/medical/reports/articles/systemic-lupus-erythematosus
http://lupus.about.com/od/faqs/f/LupHistory.htm
http://www.lupusnsw.org.au/lupus/what-is-lupus/54-history-of-lupus
http://link.springer.com/protocol/10.1007/978-1-4939-0326-9_19#page-1
http://europepmc.org/abstract/MED/24463443/reload=0;jsessionid=1izufQAjVpKZc71Zk4I5.4
http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm
http://www.medicinenet.com/script/main/mobileart.asp?articlekey=491
http://www.aafp.org/afp/1998/0601/p2753.html
Zouali, M., & Uy, E. (2013). Belimumab Therapy in Systemic Lupus Erythematosus. Biodrugs, 27(3), 225-235. doi:10.1007/s40259-013-0031-8
Systemic Lupus Erythematosus
History
Lupus: Latin for wolf
4 people who played a big role in the discovery of lupus
Rogerius
Moriz Kaposi
Sir William Osler
Josef Jadassohn
The discovery of lupus happened in three different time periods
Hormones
9 of 10 people with lupus are women
Researchers looked at relationship between lupus and estrogen
No causal effect has been proven between estrogen, or any other hormone, and lupus
Many women have more lupus symptoms before menstrual periods and/or during pregnancy when estrogen production is high
Lety Gutierrez
Angela Liccar
Carmen Liu
Ashley Randle
Chris Williams

Classical Times
When the term "Lupus" was coined
Rogerius thought the facial lesions looked like wolf bites
Neoclassical Times
1872, Moriz Kaposi was the first person to keep a journal about lupus.
He discovered 2 forms: systemic lupus erythematosus and discoid lupus
Sir William Olser and J. Jadassohn also followed up on this theory and published papers saying the same.
Discovery of the LE cell
Modern Times

Cells found in bone marrow of patients
Genetics
No gene or group of genes has been proven to cause lupus
However, lupus appears in certain families, and certain genes have been identified as contributing to the development of lupus
Twin studies
Environment
Most researchers today think that an environmental agent, such as a virus or possibly a chemical, randomly encountered by a genetically susceptible individual, acts to trigger the disease.
Ultraviolet rays from the sun
Ultraviolet rays from fluorescent light bulbs
Sulfa drugs
Sun-sensitizing tetracycline drugs
Penicillin or other antibiotic drugs
Infection
Cold or a viral illness
Exhaustion
Injury
Emotional stress
Anything else that causes stress to the body such as surgery, physical harm, pregnancy, or giving birth
Lupus symptoms vary from person to person
Nonsteroidal anti-inflammatory drugs
Antimalarial drugs-Plaquenil
Corticosteroids
Once you have been diagnosed with lupus, your doctor will develop a treatment plan based on your age, symptoms, general health, and lifestyle.
The goals of any treatment plan are to:
Reduce inflammation caused by lupus
Suppress your overactive immune system
Prevent flares, and treat them when they occur
Control symptoms like joint pain and fatigue
Minimize damage to organs
Skin & Blood
Malar rash
Vasculitis
Kidneys
Lungs & Heart
Lupus Nephritis: Inflammation of the Glomeruli
Pleural Effusion
Pericarditis
Belimumab- First ever immunomodulating biologic drug successfully studied in clinical trials for SLE.
Fully Human monoclonal IgG1 (made by identical immune cells) antibody directed at BAFF inhibiting its biological activity
Modest treatment effects but seems to improve disease activity, reduce flares, decrease steroid requirement and improve overall quality of life.
4 clinical trials (2 phase III). Corticosteroid use down 50% for patients already on corticosteroids. Auto-antibodies were reduced b 35-37% (anti-dsDNA) increased or normalized compliment levels (36%-46%)


BAFF
BAFF – B-cell activating factor or BLyS B-Lymphocyte Stimulator
Weak stimulant and potent costimulant of B-cell growth in vitro
Affects mature B-cells
Stimulates proliferation of human B cells along with other B activators
Increases Ig (immunoglobulin) production
Affects molecules involved in B-cell effector function
BAFF inhibits B-cell apoptosis and stimulates the differentiation of B cells into immunoglobulin-producing plasma cells
Full transcript