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Pharmacokinetics

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by

Laurie Tran

on 16 January 2013

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Transcript of Pharmacokinetics

Conclusion Application Competitors Pharmacokinetics - Depends on concentration of a single reactant raised to the 2nd power or two reactants raised to the 1st.
- Take more energy
- More complicated
- Double, quadruple
- Creates a linear graph and it uses inverses. The Product Doesn't depend on the concentration of reactants at all.
The graph of the change in concentration of a react on zero order is just a straight line with a slop equaling K
Only has K Who Needs
Zero Order? PK All


Day But Remember... Drugs are processed through the body, but first order kinetics describe rate of drug elimination
Pharmacy
Concept: the body will process and eliminate "half" of the drug concentration in blood every "half-life" period.
The more drug present in the bloodstream, the more that is processed and eliminated. Real Life Applications Resources - Simple
- Medium amount of energy
- Used in the elimination of drugs that a human intakes
- Saves/ helps lives PHARMACOKINETICS IS THE WAY TO GO !!! - Means "Drugs in motion", and how a patient's body processes a drug.
- Calculates typical metabolism and elimination times.
- Associated with pharmacology.
- Difference is pharmacology is the study of how a chemical will react with or affect a patient.
- Pharmacokinetics is more the logistics of the drug while it's in the body.

-The basic components of pharmacokinetics are (in order):
1. Absorb
2. Distribute
3. Metabolize
4. Eliminate Who Needs
Second Order? 1-800-FIRSTORDER MONITOR DRUGS NOW Not me! Not me! Ew. No one
likes you. have it your way Pharmacokinetic Graph - study of chemical reactions and reaction rates
- concerned with reaction mechanisms and rate laws from experimental data Concepts of Kinetic Reactions Reaction Mechanism - rates depend on reaction mechanisms
- steps leading up to products
- comprised of multiple reactions/stages
- includes slow and fast step, transitions, intermediates, catalysts Rate Law - relationship of rate in terms of rate constant (k) and concentrations of reactants
- concentrations raised to powers (order of reaction)

ex: rate=k[A]^(x)
[A]=concentration of reactant
x=order in respect to A
Order of Reaction - exponents of concentrations
0 - rate=k, no effect on rate
1 - rate=k[A] or k[B],
[M]x2, ratex2
2 - rate=k[A]^(2) or k[B]^(2) or k[A][B], [M]x2, ratex4

sum of orders of reactants = overall reaction order
Full transcript