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Base10 Nutrigenomics Intro

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Raymond McCauley

on 16 October 2017

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Transcript of Base10 Nutrigenomics Intro

Raymond McCauley
biochemistry
biophysics
electrical eng.
computer science
bioinformatics
nanotechnology
Exponential Biosciences
past:
Raymond McCauley
Nutrigenomics
rmccauley@base10industries.com
+1-650-776-4561
advisor,
consultant,
investor
Creative Commons
Attribution-NonCommercial
4.0 International
Copyright 2017, Raymond McCauley. All Rights Reserved.
Reactive
Near Future
Medicine
Predictive
DNA Microarrays
I0
Base
I0
Base
Metabolism
Supplements
Food Sensitivities
Food Tastes and Tendencies
Diet - Fat and Carbohydrate Response
Diet - Wellness Factors
Eating Behaviors and Mood

Food, Nutrition & Metabolism

How does my body respond to food?
Do I have food sensitivities?
What tastes am I programmed to like?
Can my genes help me make choices for better nutrition?

alcohol sensitivity, gluten sensitivity, caffeine metabolism,
lactose intolerance, digestion, taste profiles, etc...
Vitamins & Supplements

Am I at risk for vitamin deficiencies that might affect my
mood, energy level, or wellness?

vitamin A, vitamin C, vitamin D, vitamin E, vitamin B6,
vitamin B9, vitamin B12, vitamin K2, iron, calcium, etc.
Weight Loss & Diet

Do these genes make me look fat?
Can different dieting strategies work better for me?
Or harm me?
Do my genetics affect my eating behaviors?
Can I take advantage of quirks in my metabolism
to be healthier and happier?

sweetness detection, appetite, fat metabolism, weight control, BMI, body shape, wellness factors, response to bariatric therapy

Blood Sugar and Carbohydrates

How do your genetics help you regulate
your blood sugar levels?

sensitivity to carbohydrates, seasonal eating, responses to certain types of foods, supplements, and prescriptions

Nutrigenomics
I0
Base
Source: "Improved weight management using genetic information to personalize a calorie controlled diet," Arkadianos, et al.
Nutr J.
2007; 6: 29.
Example:
Study comparing 2 groups in a
weight management treatment program
Nutrigenomic test
Nutrigenomic test
with
without
73%
maintained weight loss
32%
maintained weight loss
average 5.6%
loss
average 2.2%
gain
57%
healthy blood glucose
25%
healthy blood glucose
We
Know
Nutrigenomics Works
All humans inherit DNA from our mothers and fathers
We each have about 3.2 billion bases, grouped into 20,000 genes that code for proteins.
Slight variations in our DNA
can make big differences
in how these protein function.
This can affect our:
physical & mental traits
susceptibilty to disease
drug response
metabolism
How DNA Works
(the short version)
A quick example:
MTHFR and folate metabolism
MTHFR
Methylene tetrahydrofolate reductase
gene:
purpose:
converts forms of folate, or vitamin B9; important in homocysteine metabolism
major variants:
C677T (rs1801133), A1298C (1801131)
...ttgaaggagaaggtgtctgcgggag
c
cgatttcatcatcacgcagcttttc...
...ttgaaggagaaggtgtctgcgggag
t
cgatttcatcatcacgcagcttttc...
Our analysis of your CBS, MTHFR, MTR, and MTRR gene variants show that
you may require more folate

and other B vitamins
in your diet in order to keep homocysteine levels low
impact: may impair enzyme processing up to 75% in 30-40% of the population, depending on racial background.
Some claims that these variants contribute to disease
are overstated
. However, associatipons do exist for homocystinuria, infertility, and a variety of cardiovascular symptoms.
Supplement your diet with leafy green vegetables to get natural forms of folate (vitamin B9), or consider a
special methylfolate supplement.
Vitamin B9 Metabolism
"Secrets of My DNA"
Wired
, March 2011
Using low-cost genetic technologies to find actionable responses to health and diet issues
Nutrigenomics Advantages
I0
Base
experienced team
IT and design platform
access to genomics
security & privacy
regulatory knowledge
network of partners
Our analysis of your CBS, MTHFR, MTR, and MTRR gene variants show that
you may require more folate

and other B vitamins
in your diet in order to keep homocysteine levels low
Some claims that these variants contribute to disease
are overstated
. However, associatipons do exist for homocystinuria, infertility, and a variety of cardiovascular symptoms.
Supplement your diet with leafy green vegetables to get natural forms of folate (vitamin B9), or consider a
special methylfolate supplement.
Vitamin B9 Metabolism
Our analysis of your
CYP1A2
gene variants show that
you are a slow caffeine metabolizer.
You may want to limit your intake of caffeine (recommended: under 200 mg per day, or about 2 cups of coffee), and not consume caffeine too late in the day.

Slow metabolizers may suffer from nervousness, insomnia, and be at higher risk of
cardiovascular disease
.
Caffeine Metabolism
We have analyzed your ESR1, FTO, and UCP2 genes to see if you are a good candidate for bariatric surgery, sometimes used to treat obesity.

You may be a good candidate for
laparoscopic mini-gastric bypass (LMGB)
. Patients with genetic profiles similar to yours achieved significantly greater BMI reduction and HbA1C level improvements after LMGB.

Around 12% of patients who undergo bariatric surgeries do not exhibit long-term weight-loss and BMI reduction, apparently because of genetic variants affecting neurotransmitters and appetite control.

Note that these results are based on a
limited set of studies
, and are still under review.
Bariatric Therapy
We have analyzed your DRD4 gene variants, and found that you are in the top 10% of risk category for seasonal eating -- increasing calorie intake and decreasing exercise during fall and winter -- and subsequent weight gain. You may also be at a higher risk for Seasonal Afective Disorder (SAD)

Being aware of this can help control it. Also, some people with similiar genetic variants to yours have used light therapy to successfully combat seasonal eating and SAD.

See other genetically-influenced eating behaviors, including
Stress Eating
,
Sweet Tooth
, and
Appetite Control
.
Seasonal Eating
Genetic Sample Guidelines
For 30 minutes, do not eat, drink, chew gum, brush your teeth, or smoke. (Water is OK)

Kit errors
Registration skipped
Two people use one kit
Non-human uses one kit
Sample is heavily contaminated
Sample is lost in mail
Lab error


Re-Analysis Policy
If sample analysis doesn't work in lab, we may try to re-run
If that doesn't work, we will send a new kit to the client to try gathering another sample. Additional fees may apply.
If we can't gather and analyze a sample after three tries, we may stop.
Generally need samples returned within 12 months of kit being distributed.

Dangers

Genetics is Only Part of the Picture, and Still in Progress
Environment, including Behavior
Incomplete understanding
Certainty versus Probability

Privacy & Distressing Information
Genetic information and Insurance
GINA and Health Insurace, Employers
Life Insurance
Misattributred paternity or adoption status


Sample Processing Errors
Failure to process
Misidentified samples
Contaminated samples
Not enough DNA
Full transcript