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Mariana Cerdeira

on 1 June 2014

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Transcript of Hepatoprotectors

Treatment of liver diseases may be done by different ways, according to etiology and pathogenesis of the disease that is been treated.
Change in diet
Change in health lifestyle
Use of Hepatoprotective drugs
Surgical Treatment
Hepatoprotectors are drugs resposible for the protections of the hepatocytes against toxic agents, acting, at least, in one of the following mechanisms:
Stabilization of the hepatocyte membrane
Neutralizatio of free radicals
Increase in the synthesis or inhibition of glutathione oxidation
Blocking the penetration of toxic substances in the hepatocytes
Decreasing of hepatic inflammation
Increasing in the synthetic activity of RNA-polymerase

In this group of drugs, there are hepatotropic agents and lipotropic agents (avoid deposition of lipids in the liver).
Hepatoprotective Agents
The Liver
The liver is a vital organ of the digestive system, it is also the largest organ in the body.
The majority of its cells are hepatocytes, but there are also Kupfer cells, stellate cells, and others.
The hepatocytes perform numerous and vital roles in maintaining homeostasis and health.

Liver Diseases
The liver supports almost every organ in the body and is vital for survival. Because of its strategic location and multidimensional functions, the liver is also prone to many diseases.
The most common include: Infections such as hepatitis A, B, C, D, E, alcohol damage, fatty liver, cirrhosis, cancer, drug damage (particularly by acetaminophen (paracetamol) and cancer drugs).
Despite the great amount of diseases that may affect the liver, they generally present clinically in distinct patterns, classified as: hepatocellular (viral hepatitis, alcoholic liver disease), cholestatic (gall stone, primary billiary cirrhosis, drug induced diseases), and mixed ( cholestatic form of viral hepatitis, drug induced liver diseases).
Kursk State Medical University
Department of Therapy N 2

Teacher: Mam Olga
Student: Mariana Cerdeira
Renata Kummer
Group: 5
Synthesis of most essential serum proteins - albumin, carriers proteins, coagulation factors, hormonal and growth factors;
Production of bile and its carriers - bile acids, cholesterol, lecithin, phospholipids;
Regulation of nutrients - glucose, glycogen, lipids, cholesterol, amino acids;
Metabolism and conjugation of lipophilic compounds for excretion in the bile or urine - bilirubin, anions, cations, drugs.
Typical hepatic syndromes are:
Pain syndrome - right hypochondrium
Dyspeptic syndrome - gastric, intestinal, billiary
Asthenic syndrome
Cholestatic syndrome
Cytolysis syndrome
Jaundice Syndrome
Portal Hypertension Syndrome
Edematous Syndrome
Hepatomegaly Syndrome
Hepatodepression Syndrome
And others
Liver functions
: is a water-soluble essential nutrient. It is usually grouped within the B-complex vitamins.
It is a lipotropic agent. It is believed that choline is capable of promoting the conversion of hepatic fat in phospholipids that contain choline, which can be quickly transferred from the liver to the bloodstream, avoiding hepatic steatose.
Choline deficiency may play a role in liver disease, atherosclerosis, and possibly neurological disorders. One symptom of choline deficiency is an elevated level of the liver enzyme ALT.
The most often available choline supplement is lecithin, derived from soy or egg yolks.
Hepatoprotective Agents
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