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iPS

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by

Lindsay allison

on 13 February 2013

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Transcript of iPS

Why IPS? iPS Cells Anna, Lindsay, and Anisa Bibliography http://www.nature.com/clpt/webfocus/ipscells/index.html
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278994/
http://www.nature.com/scitable/topicpage/turning-somatic-cells-into-pluripotent-stem-cells-14431451
http://www.economist.com/news/science-and-technology/21569363-stem-cells-may-transform-development-new-drugs-potent-medicine
http://stemcells.nih.gov/info/Regenerative_Medicine/pages/2006chapter10.aspx Why iPS? What are iPS stem cells? Breakthroughs Potential - Adult cells that are turned into pluripotent cells via transcription Factors
- Transcription factors = genes
- Adult cells commonly harvested from the skin, liver and stomach Major Contributors Obstacles -Avoid ethical dilemma

-Uses an individual's own cells

-"Provide a steady and high quality source of human cells" - Dr. James Thomson Past Researchers - Sir John B. Gurdon
- Yamanaka
- - Neurological disease cures
-skin cells to iPS cells to neurons
-allow scientists to study the progression of disease
- Personalized Treatment
-personalized medication
-possible clinical use
Subtypes for Diabetics
- insulin secreting pancreatic cells are destroyed
-other pancreatic cells turned into insulin secreting cells vector introduction of iPS cells
constant expression of the 4 genes
non-integrating vectors
propose both solutions and further complications Sickle Cell Anemia
-in mouse, iPS cells corrected the sickle cell gene
Motor neurons
-motor neurons for patient with amyotrophic lateral sclerosis (Lou Gehrigs disease) Current Researchers Yamanaka - without viral vectors
Harvard Stem Cell Institute
-George Daley, Derrick Rossi, Konrad Hochedlinger - successful papers
Full transcript