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Japan DNA Testing Workshop 2017 09

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Raymond McCauley

on 8 September 2017

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Transcript of Japan DNA Testing Workshop 2017 09

Time to try
personal genomics!

Everyone
gets a kit
Get the kit
from your packet
Swab your
cheek
Turn sample
in today
Download
the app
Receive
your results
How to participate
Individual results
in
Orig3n app
or
downloadable PDF
Use your sample number to register!
Robin Smith
Michael Fang
Marcie Glicksman
Kate Blanchard
Ed Coffey
Variants Tested
risk-seeking behavior in DRD4
language learning ability in FOXP2
folate (vitamin B9) metabolism in MTHFR
caffeine metabolism in CYP1A2
longevity in TERC
skin aging in NQ01
Source: "Improved weight management using genetic information to personalize a calorie controlled diet," Arkadianos, et al.
Nutr J.
2007; 6: 29.
Example:
Study comparing 2 groups in a
weight management treatment program
Nutrigenomic test
Nutrigenomic test
with
without
73% maintained weight loss
32% maintained weight loss
average 5.6% loss
average 2.2% gain
57% healthy blood glucose
25% healthy blood glucose
We Know Nutrigenomics Works
All humans inherit DNA from their mothers and fathers.
We each have about 3.2 billion bases, grouped into 20,000 genes that code for proteins.
Slight variations in our DNA
can make big differences
in how these protein function.
This can affect our:
physical & mental traits
susceptibilty to disease
drug response
metabolism
How DNA Works
(the short version)
A quick example:
MTHFR and folate metabolism
MTHFR
Methylene tetrahydrofolate reductase
gene:
purpose:
converts forms of folate, or vitamin B9; important in homocysteine metabolism
major variants:
C677T (rs1801133), A1298C (1801131)
...ttgaaggagaaggtgtctgcgggag
c
cgatttcatcatcacgcagcttttc...
...ttgaaggagaaggtgtctgcgggag
t
cgatttcatcatcacgcagcttttc...
Our analysis of your CBS, MTHFR, MTR, and MTRR gene variants show that
you may require more folate and other B vitamins
in your diet in order to keep homocysteine levels low
impact:
may impair enzyme processing up to 75%; occurs in 20-40% of the population, depending on racial background.
Some claims that these variants contribute to disease
are overstated
. However, associations do exist for homocystinuria, infertility, and a variety of cardiovascular symptoms.
Supplement your diet with leafy green vegetables to get natural forms of folate (vitamin B9), or consider a
special methylfolate supplement.
Vitamin B9 Metabolism
"Secrets of My DNA"
Wired
, March 2011
Using low-cost genetic technologies to find actionable responses to health and diet issues
Raymond McCauley
biochemistry
biophysics
electrical eng.
computer science

bioinformatics
nanotechnology

Exponential Biosciences
past:
Raymond McCauley
Reading the Code of Life
@raymondmccauley
+1-650-776-4561
advisor,
consultant,
investor
Creative Commons
Attribution-NonCommercial
4.0 International
Copyright 2017, Raymond McCauley. All Rights Reserved.
I0
Base
An Introduction to Personal Genomics
Yoko Shimizu
yokoshimizuart@me.com
yokoshimizu.com
Explosion of
consumer genomics
250+ companies
Ancestry
Athletic
Child talent
Matchmaking
Surreptitious
Non-legal paternity
Legal paternity
Nutrigenomics
Family
Carrier
Health testing
Microbiome
Pets
Food
?
?
?
?
Interpretation Websites
Promethease / SNPedia
Interpretome
LiveWello
Genetic Genie
23andMe
Ancestry.com
FamilyTreeDNA
Sources of DTC Genetic Data
C
=
T
=
I0
Base
Platypus
Project
Applying exponential technology
to global grand challenges
Pharmacogenomics at scale
for health systems
Edtech for biology hacking
Current Projects
Advisor & Investor
Various media projects
Illumina Custom OmniExpress+ BeadChip
Assays about 1,200,000 oligo sequences
DNA Microarray
Lets talk about these...
Get tested
Get Photographed
Share Photos & Genetic Knowledge
in Social Media
& accuracy & privacy
Future of Genetic Testing
Intelligence Testing?
Genes

Fate
?

=
Cognitive
Genomics
Project

Thank you
for
your
time,
attention,
and DNA!
Full transcript