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Japan DNA Testing Workshop 2017 09
Transcript of Japan DNA Testing Workshop 2017 09
gets a kit
Get the kit
from your packet
How to participate
Use your sample number to register!
risk-seeking behavior in DRD4
language learning ability in FOXP2
folate (vitamin B9) metabolism in MTHFR
caffeine metabolism in CYP1A2
longevity in TERC
skin aging in NQ01
Source: "Improved weight management using genetic information to personalize a calorie controlled diet," Arkadianos, et al.
2007; 6: 29.
Study comparing 2 groups in a
weight management treatment program
73% maintained weight loss
32% maintained weight loss
average 5.6% loss
average 2.2% gain
57% healthy blood glucose
25% healthy blood glucose
We Know Nutrigenomics Works
All humans inherit DNA from their mothers and fathers.
We each have about 3.2 billion bases, grouped into 20,000 genes that code for proteins.
Slight variations in our DNA
can make big differences
in how these protein function.
This can affect our:
physical & mental traits
susceptibilty to disease
How DNA Works
(the short version)
A quick example:
MTHFR and folate metabolism
Methylene tetrahydrofolate reductase
converts forms of folate, or vitamin B9; important in homocysteine metabolism
C677T (rs1801133), A1298C (1801131)
Our analysis of your CBS, MTHFR, MTR, and MTRR gene variants show that
you may require more folate and other B vitamins
in your diet in order to keep homocysteine levels low
may impair enzyme processing up to 75%; occurs in 20-40% of the population, depending on racial background.
Some claims that these variants contribute to disease
. However, associations do exist for homocystinuria, infertility, and a variety of cardiovascular symptoms.
Supplement your diet with leafy green vegetables to get natural forms of folate (vitamin B9), or consider a
special methylfolate supplement.
Vitamin B9 Metabolism
"Secrets of My DNA"
, March 2011
Using low-cost genetic technologies to find actionable responses to health and diet issues
Reading the Code of Life
Copyright 2017, Raymond McCauley. All Rights Reserved.
An Introduction to Personal Genomics
Promethease / SNPedia
Sources of DTC Genetic Data
Applying exponential technology
to global grand challenges
Pharmacogenomics at scale
for health systems
Edtech for biology hacking
Advisor & Investor
Various media projects
Illumina Custom OmniExpress+ BeadChip
Assays about 1,200,000 oligo sequences
Lets talk about these...
Share Photos & Genetic Knowledge
in Social Media
& accuracy & privacy
Future of Genetic Testing