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Neurotransmitters and neurotransmission
Transcript of Neurotransmitters and neurotransmission
Body functions are largely controlled and integrated by the central nervous system
Neurotransmission: The process by which a neuron releases signaling molecules which bind and activate receptors of another cell.
Neurotransmitter: Endogenous chemicals
released by neuron to signal
Discovery of chemical neurotransmission
Otto Loewi's experiment provided
the first evidence for the existence of chemical neurotransmission
of the synapse
Synapse: The site of chemical transmission
Life cycle of a neurotransmitter
After an action potential fires...
Classes of neurotransmitters
Glutamate, GABA, glycine
Neuroscience Core Lecture
Modifications of synaptic transmission by drugs and disease
Drugs can modulate neurotransmission at many levels
GABA: gamma-aminobutyric acid: Inhibitory
Glycine: Modulates excitatory and inhibitory
Reward and motor
Motor control and sensations
Nitric oxide and carbon monoxide
Reduce NT release
Increase NT release
endogenous opioids, substance P
DA, NE, 5-HT
Targets SNAREs on excitatory
Trauma causes cell death
Release of excess glutamate
Results in toxic calcium influx
Propagates death in surrounding