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Overexpression of Catalase in Vascular Smooth Muscle Cells P

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Nihal Varkey

on 21 January 2014

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Transcript of Overexpression of Catalase in Vascular Smooth Muscle Cells P

Ioannis Parastatidis, Daiana Weiss, Giji Joseph, W. Robert Taylor
Overexpression of Catalase in Vascular Smooth Muscle Cells Prevents the Formation of Abdominal Aortic Aneurysms
By Jessica Reed, Nihal Varkey, Riddhi Machchhar, and Nadia Mohammadi
Abdominal Aortic Aneurysms (AAA)
ROS: A Curious Case

Does the hydrogen peroxide scavenger enzyme, catalase, have an effect on vascular wall injury, eventually leading to the formation of an AAA?
Reactive Oxygen Species (ROS) and Abdominal Aortic Aneurysms (AAA)
Endothelial Dysfunction and Effect on Vascular Smooth Muscle Cells (VSMC)
A Case Study
A 75-year old German born male physicist presented to the clinic for an annual physical exam. Upon completion, you, as the lead physician, become aware of following : he is tachycardic, has hypertension, and smokes. The physician also noticed a pulsating abdominal mass, which showed tenderness.
Effects of Vascular Injury on Vascular Wall Catalase and Hydrogen Peroxide
Effects of Infusion of PEG-Catalase on Vascular Wall Injury

Effects of Catalase Overexpression in VSMC on AAA Formation
Catalase and MMP Activity
Primary cause of 10,597 deaths
Contributing cause in more than 17,215 deaths
Two-thirds are male
Men aged 65–75 years
Previous Work and AAA Models
AAA Models
Angiotensin 2
Tamoxifen
Calcium Chloride
Discussion of Results and Findings
MMPs and the Extracellular Matrix
TNF-Alpha and Apoptosis
What are the Limitations?

PEG-Catalase Infusion vs Catalase Overexpression
Hydrogen Peroxide Levels in Experimental Groups
Back to the Case...

January 21, 2014
Advances in Cardiobiology
Objective and Hypothesis
Reduced Apoptosis in Catalase Overexpressing Aortas
Attenuated Inflammatory Response in Transgenic Mouse
Total Hydrogen Peroxide Levels
The Controversy of TGF Beta 1
Full transcript