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"Ever-changing Moods May be Toxic to the Brain of Bipolar Pa

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Mahema S

on 7 June 2016

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Transcript of "Ever-changing Moods May be Toxic to the Brain of Bipolar Pa

Questions??
A new study shows that the blood of bipolar patients is toxic to brain cells, particularly affecting the connectivity ability of neurons
Bipolar Disorder
Mental disorder characterized by:
severe mood swings of extreme highs and lows
Lasting for months at a time
High state of mania
Low state of extreme depression
Usually first occurs in early 20's
Effects 2% of the world's population
Study Hypothesis
The recent study has shown results that the levels of certain markers in the blood related to stress, and neurotrophins(proteins that promote neuron growth and survival) are associated with recurrent mood episodes.
A Group at the Federal University of Rio Grande do Sul lead the research
The group found that neuron exposed to the blood serum of late stage bipolar patients saw significantly more deterioration than the neuron exposed to the blood of healthy individuals.

Interestingly, there was no significant difference between the neurite density of early state bipolar patients and healthy individuals...what could this mean for treatment options??
This is the first documented study that proves the effects of bipolar patients blood on the brain. Future studies will be geared towards finding drugs that can protect BD patients from the effects of their own blood.
Quick Review: Bipolar Disorder
Sciencedaily.com
"Ever-changing Moods May be Toxic to the Brain of Bipolar Patients"
"If these blood markers can be associated to the severity and frequency of mood episodes in BD patients, is it possible that they are also associated to changes observed in the brain of BD patients?"


A bipolar brain often shows reduction of volume and neuroprogression. This process is associated with loss of neuron connections, which in turn leads to loss of memory cognitive deterioration.
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