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Sickle Cell Anemia
Transcript of Sickle Cell Anemia
What is it?
Sickle Cell Anemia
A mutation of a single nucleotide of the 400 that code for the hemoglobin protein
This causes a change in one of the amino acids that make up the protein
What Causes Sickle Cell Disease?
Malaria, a serious disease caused by parasites that are passed on to people through bites of mosquitoes that are infected
(Why the Mutation occurred)
Living with sickle cell Anemia
"A Case Study of the Effects of Mutation: Sickle Cell Anemia." A Case Study of the Effects of Mutation: Sickle Cell Anemia. N.p., n.d. Web. 05 May 2014.
Freeman, Shae. "Facts About Sickle Cell Anemia." EHow. Demand Media, 27 Jan. 2009. Web. 05 May 2014
"Sickle Cell Anemia." KIdsHealth. Ed. Robin Miller. The Nemours Foundation, 01 Sept. 2012. Web. 04 May 2014.
"Sickle Cell Anemia." Mayo Clinic. N.p., n.d. Web. 05 May 2014
"Symptoms of SCD." Symptoms of SCD. Be The Match, n.d. Web. 05 May 2014.
"What Is Sickle Cell Anemia?" - NHLBI, NIH. N.p., n.d. Web. 05 May 2014.
Normal red blood cells
disc-shaped & flexible
have normal hemoglobin
live about 120 days
crescent- shaped, sticky, stiff, & fragile
live about 10 - 20 days
About 70,000-100,000 Americans are affected by sickle cell anemia
1 out of every 500 African American births
more than 1 out of every 36,000 Hispanic American births
contain abnormal hemoglobin called sickle hemoglobin (deliver less oxygen to the body's tissues)
Central or South America
Caribbean islands, Mediterranean countries
When malarial parasites get into the bloodstream, the red blood cells with abnormal hemoglobin become sickled and die, reducing infection by trapping the parasites inside them
Protection against Malaria
Shortness of breath
Coldness in hands and feet
People with sickle cell Anemia inherit two genes for sickle hemoglobin—one from each parent
Living with sickle cell anemia is difficult but patients can still live productive lives
Hospital visits (regular medical care)
They have to change their lifestyle in order to avoid anything that may cause a crisis, such as certain medications, high altitudes, and intense exercise
medications (strong pain medicines)
painful episodes: crises
blocked blood flow
low number of red blood cells
A blood and marrow stem cell transplant
: a procedure that replaces a person's faulty stem cells with healthy ones (may offer a cure for few people)
: procedure in which you receive blood through an IV line inserted into one of your blood vessels
: medicine that helps reduce how often pain crises and acute chest syndrome occur
"Sickle Cell Anemia: MedlinePlus." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 05 May 2014.