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Sickle Cell Anemia

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by

Meti Teshome

on 6 May 2014

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Transcript of Sickle Cell Anemia

Sickle Cell Anemia is an inherited disease in which healthy red blood cells form into sickle shaped cells


What is it?
Sickle Cell Anemia
A mutation of a single nucleotide of the 400 that code for the hemoglobin protein

This causes a change in one of the amino acids that make up the protein




What Causes Sickle Cell Disease?
Inheritance
Malaria, a serious disease caused by parasites that are passed on to people through bites of mosquitoes that are infected



HISTORY
(Why the Mutation occurred)
Treatments
Symptoms
Living with sickle cell Anemia
"A Case Study of the Effects of Mutation: Sickle Cell Anemia." A Case Study of the Effects of Mutation: Sickle Cell Anemia. N.p., n.d. Web. 05 May 2014.

Freeman, Shae. "Facts About Sickle Cell Anemia." EHow. Demand Media, 27 Jan. 2009. Web. 05 May 2014

"Sickle Cell Anemia." KIdsHealth. Ed. Robin Miller. The Nemours Foundation, 01 Sept. 2012. Web. 04 May 2014.

"Sickle Cell Anemia." Mayo Clinic. N.p., n.d. Web. 05 May 2014





"Symptoms of SCD." Symptoms of SCD. Be The Match, n.d. Web. 05 May 2014.

"What Is Sickle Cell Anemia?" - NHLBI, NIH. N.p., n.d. Web. 05 May 2014.






Bibliography

Normal red blood cells

disc-shaped & flexible

have normal hemoglobin

live about 120 days





Sickle cells
crescent- shaped, sticky, stiff, & fragile
live about 10 - 20 days
About 70,000-100,000 Americans are affected by sickle cell anemia

1 out of every 500 African American births

more than 1 out of every 36,000 Hispanic American births
contain abnormal hemoglobin called sickle hemoglobin (deliver less oxygen to the body's tissues)
Africa
Central or South America
Caribbean islands, Mediterranean countries
When malarial parasites get into the bloodstream, the red blood cells with abnormal hemoglobin become sickled and die, reducing infection by trapping the parasites inside them



Protection against Malaria
Pain

Anemia

Tiredness
Weakness
Shortness of breath
Headaches
Dizziness
Coldness in hands and feet


India
People with sickle cell Anemia inherit two genes for sickle hemoglobin—one from each parent




Saudi Arabia
Living with sickle cell anemia is difficult but patients can still live productive lives

Pain crises
Hospital visits (regular medical care)

They have to change their lifestyle in order to avoid anything that may cause a crisis, such as certain medications, high altitudes, and intense exercise

medications (strong pain medicines)
painful episodes: crises
blocked blood flow
organ damage
low number of red blood cells
A blood and marrow stem cell transplant
: a procedure that replaces a person's faulty stem cells with healthy ones (may offer a cure for few people)


Blood transfusions
: procedure in which you receive blood through an IV line inserted into one of your blood vessels


Hydroxyurea
: medicine that helps reduce how often pain crises and acute chest syndrome occur
"Sickle Cell Anemia: MedlinePlus." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 05 May 2014.
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