Germline Therapies - REBUTTAL

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by ruben hyndal2 views·Updated Aug 12, 2021
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  1. The opposition maintains the belief that Germline therapies would eradicate
  2. genetic disorders and diseases more effectively and time efficiently than
  3. what is currently accessible.
  4. It was mentioned that if medical science underwent further research
  5. and development in the field of germline therapy, it could
  6. be an option for treating genetic conditions very early on
  7. with a particular focus on cancer and sickle cell disease.
  8. The opposition discussed the benefits of using Germline therapy to
  9. eradicate the genes that code for specific genetic disorders and
  10. how the current methods of treatment are too time consuming
  11. to which I say the extent of the extent of
  12. which current cancer therapies of research and successful a time
  13. consuming procedure would be the least of a patient's worries.
  14. Whereas with Germline therapies, the time consuming nature and the
  15. lack of medical knowledge will and should lead to patient
  16. hesitance as the costly and time consuming method of curing
  17. genetic disorders may not even work.
  18. The opposition only covered the tip of the iceberg when
  19. it comes down to overall practicality of the therapies it
  20. was mentioned and encouraged that Germline therapies with the correct
  21. research and funding put behind them could very well become
  22. the new revolutionary medical breakthroughs.
  23. Although this could indeed be the case from what research
  24. has shown so far.
  25. Even if the therapy did get to a point of
  26. being used successfully on people completely risk free because of
  27. the publicity involved with the commotion and connotations associated with
  28. germline therapy, there would be a higher chance of people
  29. opting out of germline therapy and sticking with the currently
  30. available procedures.
  31. Additionally, who is going to willingly put their money into
  32. research and advancements of a therapy that in all its
  33. years have possibly been the next scientific medical breakthrough has
  34. shown no promise and in fact uncovered more reasons not
  35. to go ahead with its progression at all, particularly when
  36. there are already suitable methods being used to treat genetic
  37. disorders. The opposition mentioned that 5-10% of cancers are heritable
  38. that of which is true and is a very big
  39. underlying issue all around the world.
  40. There are in fact multiple, accessible cheek and successful methods
  41. for managing and in some cases eradicating cancer cells from
  42. the patient's body entirely, such as chemotherapy.
  43. It was mentioned that the process of chemotherapy was very
  44. time consuming.
  45. And although the statement is true, the processes, success rates
  46. and overall medical knowledge available on the outcomes is far
  47. more reliable and accessible than germline therapy.
  48. Cancer management and research, particularly in Australia, is heavily funded
  49. by the government and we, as a country, holds one
  50. of the highest rates in certain cancers and yet have
  51. one of the lowest related mortality rates.
  52. Chemotherapy uses anti cancer drugs often in combination with radiation
  53. therapy and all surgery, but it can be used alone.
  54. It just depends on the cancer type and the overall
  55. severity of the situation.
  56. Although as mentioned, chemotherapy is rather time consuming a level
  57. of predictability held by professionals and the overall public accessibility
  58. outweigh the time it takes for patients to undergo this
  59. treatment. Human therapy also allows patients to personally elect for
  60. treatment once they understand the ways that cancer may impact
  61. and change their lives.
  62. Not only is chemotherapy cheaper, more accessible and more reliable,
  63. it does not hold the unethical powers that germline therapy
  64. does. There is an idea that people with genetic disorders
  65. and conditions are bedridden, incapable, miserable people in hospitals their
  66. whole lives, although this can be the case with some
  67. genetic disorders, Some, including sickle cell disease, do have their
  68. benefits. Sickle cell disease affects the hemoglobin that carries oxygenated
  69. red blood cells around the body for cellular respiration, causing
  70. less oxygen to be carried to the extremities and organs
  71. of the body.
  72. The traditional by concave nature of red blood cells is
  73. altered by sickle cell disease, which causes more hard, compact
  74. and thin blood cells, which ultimately does affect the rate
  75. of the human globe and carrying oxygen successfully sickle cell
  76. disease. Although in and of itself isn't fatal.
  77. Some complications that follow as a result of the disease
  78. can be.
  79. Although single self disease has possibly fatal implications, such as
  80. strokes, it does actually have some benefits.
  81. The benefits that come with sickle cell disease.
  82. Our immunity to malaria As a result of this inherent
  83. immunity to such a deadly disease that kills almost 409,000
  84. people a year, according to the World Health Organization, there
  85. is an incentive to stop genetic alteration of people with
  86. sickle cell disease.
  87. The benefit of not using Germline therapies to genetically edit
  88. people with this disease is that they can be medically
  89. examined to understand malaria further and possibly come up with
  90. more options for increasing immunity around the world.
  91. For all the reasons mentioned in this video and the
  92. previous one, Germline therapy is to underdeveloped to introduce to
  93. humans successfully.
  94. Germline therapy should not be explored or introduced to medical
  95. clinics or made publicly accessible.
  96. This conclusion is reached through consideration of the costs, risks
  97. involved, the overall unpredictability of outcome and the overarching possibility
  98. of future genetic genocide.
  99. Although the currently available methods of eradicating genetic disorders such
  100. as cancer do need further development, they have got to
  101. a point of success that is accessible to the public
  102. and continues to be modified to increase success rates and
  103. treatment plans as a whole.
  104. In saying this, there are already multiple, suitable therapies and
  105. management plans in place that we won no work to
  106. maintain, affordable and accessible to the public, with minimal risks.
  107. And three can be sought after by the patient, rather
  108. than a non consensual and invasive procedure that affects their
  109. life, Okay.