Sickle-Cell

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by Iman Guled5 views·Updated Feb 25, 2022
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  1. Hello. I'm Eamon and I'm going to be explaining
  2. the disorder or trait of sickle cell anemia.
  3. So what exactly is psycho selon email.
  4. Sickle cell anemia is an inherited blood disorder
  5. where red blood cells become sickle or crescent shape
  6. hence the name sickle cell anemia.
  7. So how does sickle cell look within the affected humans?
  8. People with this disorder experience frequent infections,
  9. swelling in the hands and legs. And those who experience it
  10. express having severe pain.
  11. Sickle cell anemia isn't really a disorder where there's a lot of physical
  12. attributes to it.
  13. So a person with um sickle cell won't really look like it from the outside.
  14. But within they are actually affected very much with low levels of
  15. mm hmm
  16. of hemoglobin and
  17. just super
  18. fatigue and in pain constantly.
  19. I will say though um people with this disorder usually have jaundice
  20. which on the outside appears with
  21. with them having yellowing of the skin.
  22. Which is really a main factor why a lot of
  23. people who have psycho cell go in to get tested?
  24. Because
  25. that is a big sign.
  26. Now what is the genetic basis of psycho cell anemia?
  27. The gene associated with this this disorder that is being affected is the H. B. B.
  28. Gene which is abbreviated for hemoglobin
  29. which is a protein found in red blood cells that deliver oxygen to the body.
  30. So low levels of hemoglobin is commonly linked with anemia.
  31. Which I'm sure a lot of you are familiar with
  32. hearing people say that they're anemic which is really
  33. common in the general population especially with teen girls.
  34. So the way that sickle cell anemia is inherited or the pattern that is inherited in
  35. um is in a homo zaius recessive pattern meaning that
  36. the same alil is inherited.
  37. It is also out of Somalia recessive,
  38. meaning both males and females can be affected within families.
  39. Okay so here is
  40. the family tree I drew
  41. to show this trait within families.
  42. And as you can see within the first generation
  43. both parents, although they weren't actively having this disorder,
  44. they were carriers which then led to their offspring in the second generation
  45. either having it or carrying
  46. this disorder.
  47. So with this specific disorder um in order for offspring to have it
  48. or to either to even be a. Well
  49. they can be carriers if one of their parents
  50. have it but in order to have it themselves,
  51. both parents have to either carry it or either have that specific traits.
  52. So as you can see on the third generation there are two
  53. offspring that
  54. um
  55. aren't showing them either having it or
  56. being carriers. And I'm not sure we're not sure if they have it.
  57. They have a possibility
  58. which is why
  59. it's either says a capital A
  60. slash um capital A. And lower case A. So capital A. Is um not affected
  61. and little case A. Is affected. So
  62. we're not really sure if they are
  63. carriers or
  64. nuts.
  65. But as you can see that
  66. this um specific disorder will always trace back
  67. to a root common ancestor back from generations to generations to generations.
  68. So just to go over this again um the train is inherited
  69. through both parents either having the trait or carrying.
  70. So one parent can have the trait and another parent can be a carrier.
  71. And um so both parents have to be carriers or have to have
  72. it within themselves in order for our offspring to have that trait.
  73. Otherwise if only one parent has the gene, the
  74. offspring may or may not carry it
  75. themselves.
  76. Um
  77. So yeah
  78. so the way that the tree shows how common ancestry works as I stated before,
  79. there will always
  80. the
  81. you will always be able to trace back the tree in the family tree.
  82. So it'll keep going back through generations
  83. even before the first generation
  84. that I showed.
  85. So it can go even further back
  86. or further down the line. It will always be within
  87. the tree, told to show how
  88. common ancestry works.
  89. You'll always be able to trace it back
  90. three generations That
  91. thank you so much and I hope that this gave you guys a better understanding of how
  92. traits
  93. are shown within family trees.