STUDY ON DISINTEGRATION TIME OF DIFFERENT BRANDS OF PARACETAMOL TABLETS

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by zahra zaidi0 views·Updated Feb 28, 2022
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  1. Salaam Alaikum and Good morning. My name is senora.
  2. So Sevilla's Aravinda Mama society
  3. from pharmacy technician in six year seven.
  4. Today I would like to present my project work on
  5. the study of disintegration time of different brands of personable tablets
  6. with so many brands coming up with different formulations of paracetamol.
  7. It is doubted by public on which one is the best. Are all of them the same.
  8. What is the difference between brands and generic person metropolis.
  9. In this project,
  10. my team and I tested 10 different personal mobiles to
  11. determine the time it took for each tablet to disintegrate.
  12. Disintegration is defined as the mechanical breaking up of
  13. a compacted tablet into minute Granules after swallowing.
  14. The major goal of this research is to determine which tablet is useful
  15. for a particular condition and to compare
  16. the advertising claims of various percival brands
  17. so little background history.
  18. Paracetamol is the most commonly prescribed analgesics and antibiotics
  19. for both adults and Children on the market.
  20. Today
  21. it has a great safety profile when you use
  22. at the perfect dose is
  23. lacking the gastrointestinal adverse effect by aspirin and ibuprofen have.
  24. So the difference between brand name drugs, engineering drugs is that
  25. brand name drugs are medications that are patented,
  26. manufactured and licensed for the first time.
  27. General drug on the other hand are medications that are baiocchi,
  28. Bulent to brand name drugs and contain the same
  29. active components but are made by different manufacturers.
  30. When the patent expires in the study, the active ingredient is personable
  31. in terms of identification,
  32. strength quality purity, safety, potency usage and treatment,
  33. generic medications are identical to branding drugs.
  34. So my aim and objective miss parlor is to
  35. investigate the time taken for each tablet to disintegrate
  36. to determine which tablet is appropriate for specific conditions.
  37. To compare advertising claims of various personal brands and to distinguish
  38. between brand and generic person fall in terms of disintegration time.
  39. So my hypothesis for this study is that if we
  40. follow our plan and completely stages in the correct order,
  41. our results will be satisfactory and within the range of
  42. predictions suggesting that the tablet coating affects the disintegration time.
  43. So here's our methodology
  44. to first we search for various personal
  45. metabolism or commercially accessible or available overnight
  46. and then we plan and discuss on how to get out to disintegration experiment
  47. We conclude to simulate the stomach condition.
  48. We set the hydrochloric solution to be in a range of 1-9-2.2
  49. and the temperature to be between 34-37°C.
  50. Then we established the lab experiment and conduct the experiment in groups.
  51. We did it in paris
  52. We took account of the quantitative data from the experiment
  53. and repeat at least three times to achieve the average.
  54. So here are all the personable tablets that we investigated.
  55. We do
  56. 10 different pills, five generic tablets and four branded.
  57. So the five generic tablets are the formal temple puro, paracel and actor max.
  58. The branded ones are Panadol, active fast
  59. of these orb
  60. little plane and Penneteau extent.
  61. So here are our, our methods to do the study first.
  62. We wear safety goggles, lab coat gloves and masks.
  63. And then we disinfect everything the the bench, the beach meted,
  64. bickered magnetic spirit, everything.
  65. And then
  66. we fill
  67. Hydrochloric solution up to
  68. 300 mil
  69. and then check using the ph meter, making sure the solution has a ph level.
  70. That that's the
  71. way it's supposed to be between
  72. 1 - 9 - 2.2.
  73. And then we switched on the hot plate to speak rate
  74. of one and we hit the solution to a temperature between 34-37°C.
  75. We use a thermometer to check the temperature to make sure it's within the range.
  76. And then once the
  77. And then once the solution reaches 34-37°C. We put in
  78. the personal tablets and at the same time we checked
  79. the
  80. time
  81. and then we stopped the stopwatch
  82. and then the tablets integrates into
  83. half
  84. of the tablet or two tiny grains.
  85. And then after that we record ph solution
  86. and then we repeat the process up to
  87. three times to achieve
  88. average.
  89. Okay,
  90. so
  91. our results
  92. shows that
  93. Panadol of dessert is the fastest disintegrating
  94. uh tablet.
  95. 403.16 seconds. Second one is active. Panadol activa has which is 111.5 seconds.
  96. The second one is Panadol plane which is 270 parks second and the last one,
  97. The slowest one to disintegrate
  98. is Panadol extent. It's 4007 seconds.
  99. For
  100. mm hmm.
  101. For the average disintegration time for generic personal tablets.
  102. The slowest one is Ufo Mall, which is 256.5 seconds. Second one is back to max.
  103. Um,
  104. It disintegrates 205 seconds.
  105. And then it's temple with 154.3 seconds,
  106. Poirot
  107. 89.89.0 seconds.
  108. And then Panama 2nd last is 38.8 and the fastest one to disintegrate is paracel
  109. with 34.5 seconds.
  110. Okay,
  111. so according to the findings,
  112. the slowest tablet to disintegrate in a hydrochloric solution
  113. in the range
  114. of
  115. ph 1.9 to 2.2 1st, Direct personal It's Eva Mall
  116. and then
  117. Actor Max Temple and Quarrel though there is a slight
  118. difference in the disintegration time between personal and from all,
  119. the fastest one is personal.