ISMRM Low field workshop KH

how many's Katie Hannah and I'm a final Your PhD student at the University of

Aberdeen on today are representing on our pre

clinical work using fast food cycling anymore.

We like solitary

to city breast cancer,

So I just want to introduce my research

question on discuss why we're actually sitting this

So for your breast cancer is one of the leading causes of cancer related deaths.

World weighed

on.

According to the global can estimates 680,000 deaths were recorded in 2020 alone.

The majority of these deaths can be attributed to mental cited disease,

whereby the tumour has spread from its primary state, the breast

to distant targets.

The majority of metastatic cases of either a

result of initial diagnosis occurring at a late stage

or recurrence from a previous breast cancer diagnosis

and therapeutic options for metastatic disease are currently rather limited

and as such remains largely incurable.

Therefore,

the early detection and accurate assessment of

recurrence risk in the early stages of disease

is imperative for 80 treatment decisions and improving outcomes.

So and I do tool for investigating breast cancer would be one

that could not evasively and objectively

provide quantitative information on sugar characteristics

and one potential candidate could help achieve

this goal is asked about cycling anymore.

This is a tape of the solitary that

involves the use of a rapidly changing magnetic field

to facilitate the measurement of the longitudinal relaxation time

or rate as a function of magnetic field strengths

and on the left.

Here is just a schematic of a typical fast politically pulse sequence,

which comprises of three distinct fertile period polarisation,

evolution and detection,

each of which are applied at a different magnetic field strength.

About repeating this sequence we can obtain T Warner

are one values over a range of evolution.

Field

everything plot this as a dispersion curve.

Biological tissue are one or 21 dispersion is related

to the motion and international water at proteins,

which is some of the most abundant proton containing elements

on the dynamics of these component molecules.

Within tissue is greatly depending on whom you static balance,

which itself is lost in the licensee

in the overall shape of the dispersion curve,

is determined by all of the molecular dynamics within the tissue,

and it's sensitive to any modifications to its architecture

and alterations to normal tissue architecture of some of the

key events that lead to malignant transformation and medicine.

Attic progression.

And so the physical information contained within the dispersion curve

could prove to be a rich source of diagnostic or prognostic information.

So the main objectives of this study are

to discredit the physical features of this book.

Repeating this sequence.

We can obtain t one or are one values over a range of evolution fields.

I was employed this as a dispersion curve.

Biological tissue are one or 21 dispersion is related

to the motion and international water at proteins,

which is some of the most abundant proton containing elements

on.

The dynamics of these component molecules of in tissue

is greatly depending on whom your static balance,

which is self, is lost in the licensee.

And the overall shape of the dispersion curve is determined

by all of the molecular dynamics within the tissue.

On its sensitive to any modifications to his architecture

and alterations to normal tissue architecture of some of the

key events that lead to malignant transformation and medicine.

Attic progression.

And so the physical information contained within the dispersion curve

could prove to be a rich source of diagnostic prognostic information.

So remain objectives of the study are to describe

the physical features of disparaging currents from human grace.

Cancer tissue samples from the two heroes on on the surrounding regions

on then to use mathematical models to investigate her.

Numerical parameters derived from these cars

could potentially serve as bio markers for breast cancer detection.

And this gratification

So with ethical approval.

Issue was obtained from 20 female breast cancer patients undergoing Wade

local excision and mistake to me at the Aberdeen Royal Infirmary

Specimen or Fixing for Mullen.

And then samples were obtained from different areas

of each of the 20 century post vestment

shown in the diagram.

A special

use pressed his the pathologist,

a specialist breast test a pathologist.

Nature of the samples was recently validated by a second test. The Pathologist

Dispersion Council Rickard from each of the 140 fixed

tissue samples using the smart trace a spell.

Taylor,

These in this factory so still benched. Hoppy likes ometer.

Yeah, some of her measurements were performed at 37 degrees

on each sample was scanned with 30 different evolution fields.

In the points, there was little 1 to 8 megahertz proton, lamb or frequency beach

arwen dispersion codes required for each sample within 20 minutes.

So they announce of dispersion currents has achieved using this offer fit like two,

which is coded under Matt Lab.

All the raw data from the relaxed orbiter was imported into the software

on the fitting of each privatisation to keep Carver's

Carriedo by using the same process and paint,

then each time

to generate the dispersion codes.

So next I just clotted the average Kirsten each region,

and we can actually see clear and distinct dispersion curves,

particularly between the tumour and the pink and the three other regions.

All cars demonstrated a downward linear trend,

were imported using a double or graphic scale.

And this corresponds to power laws.

And previous work by our team has found that the

power long model fits very well with such dispersion cars.

And since two or three relaxation regimes

highlighted by the dotted lines or visible from the average curves,

each individual dispersion curve was fit using their

two out of three segment power model.

So next year,

medical parameters from the parallel equations were exported and evaluated,

and here I've just tried to show the schematically.

So we have the soap that low, medium and high field,

the transition frequencies between them and also the

vertical of state of the whole curve.

First,

the medical parameters were evaluated in the context of the tissue region

to investigate the utility for the detection and diagnosis of breast cancer.

Actually, the vertical offset this so but low medium high field Andre.

So next you medical parameters from the

power law equations were exported and evaluated.

And here I've just tried to show the schematically.

So we have the soap that low, medium and high field,

the transition frequencies between them and also the

vertical of state of the whole curve.

First light.

These numerical parameters were evaluated in the context of the tissue region.

Investigate the utility for the detection and diagnosis of breast cancer.

Actually,

the vertical offset this so but low medium high field on

the high court transition frequency

could all significantly distinguish the tumour

from all are some of the other regions of breast tissue.

Secondly,

these numerical parameters were evaluated in the

context of nautical proposing index scores,

and this is an internationally validated clinical pathological tool

that is used for Rhys transit vacation in breast cancer patients on.

Based on the score, patients can be grouped into one of five diagnostic categories.

Excellent, good,

moderate, one moderate to and poor.

So the patients in our study belong to the latter three categories.

So I've just displayed box plots from the statistically significant comparisons.

And interestingly, it was actually the dispersion curves from the distant,

non cancerous tissue

that produced significant differences,

possibly suggesting that the earliest by physical changes

related to disease progression a current in the periphery

rather than within

the tumour itself.

When I was looking at the box,

possibly each of the region's actually noticed that in the normal and

oppose group a reduction in the median vertical offset and soap medium field

parlour the worst prognosis.

And actually we did find that there was a

moderate negative correlation between the noting on producing index,

moderate tiu and poor.

So the patients in our study belong to the latter C categories.

So I've just displayed box parts from

the statistical significant comparisons and interestingly,

it was actually the dispersion curves from the distant, non cancerous tissue

that produce significant differences,

possibly suggesting that the earliest by

physical changes related to disease progression,

a current in the periphery

rather than within

the tumour itself.

When I was looking at the box,

possibly each of the region's actually noticed that in the normal Adipose

Group a reduction in the median vertical offset and soap medium field

parlour the worst prognosis.

And actually we did find that there was a moderate negative

correlation between the Nottingham Progressive Index

score on the vertical officer,

or so put low field

or so but medium field.

So just to finish,

we have shown that significant difference exists between the physical

dispersion curve of cancers and non cancer is placed issue,

which is an agreement with previous work carried out by our group and others.

And here we have made the first step to systematically

establish quantification of dispersion cars from breast cancer samples.

And overall, we have shown that the decision comes in me house novel,

Quantitative diagnostic and problems State biomarkers.

Thank you so much for listening

ISMRM Low field workshop KH

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