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Site Selection Methodology 2015

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Medical Development Team

on 3 February 2015

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Transcript of Site Selection Methodology 2015

Based on statistical concepts of sample size, variation, confidence intervals, margin of error
Worked with RME to calculate CIs for each programme (based on size and score variation)
Identify target # of sites for each programme
A little statistics review...
Review current methodology
Describe proposed approach
Discuss resource implications
Strategy for 2015
Purpose
Reasons for re-evaluation:
Programme expansion
C&OR/SF composition
Interpretation of scores
Country requests to visit more sites
Current Methodology
Small programmes: need to visit most sites
Larger programmes: need to visit more C&OR and fewer SF
Total # of sites to be visited increases in some programmes and decreases in others
What this will change
<15 approach: Increases >3 sites in 9 programmes (4 P2P)
<20 approach: Increases >3 sites in 5 programmes (4 P2P)
Resource Implications
Balance between statistically sound methodology and feasibility
What is realistic?
Ideas and suggestions?
Challenges
Site Selection Methodology 2015
Proposed New Approach
# Sites needed to visit to be able to detect a 15% difference between years
Based on Confidence Intervals...
# Sites needed to visit to be able to detect a 20% difference between years
*See Excel doc for specific changes in # of sites per programme
What does this mean for QTA Scores?
For <15: If a programme has 13 centres, and you visit 7 of them, a QTA score of 80 could be as low as 72.5 or as high as 87.5 (+/- 7.5)
For <20: If a programme has 13 centres, and you visit 6 of them, a QTA score of 80 could be as low as 70 or as high as 90 (+/- 10)
If you visit fewer sites than the # on <20 list, the margin of error will be greater than +/-10
Full transcript