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Sickle Cell Anemia

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Jack E

on 27 October 2014

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Transcript of Sickle Cell Anemia

Sickle Cell Anemia
Main Effects of the Disease
The main symptoms of the disease is severe chest pain and the blockage of blood flow.
DNA Mutation of Disease
DNA: | | |
Amino Seq: GAG

Protein: Glutamic Acid
DNA: | | |
Amino Seq: GUG

Protein: Valine
Hemoglobin (protein)
Hemoglobin carries oxygen for the red blood cell, but when it is mutated the hemoglobin clumps together due to the abundance and stickiness of the replaced amino acid: Valine.
Mutated Individual
Normal Individual
abnormal hemoglobin blocks blood flow to and from the organs
Organ Failure
Pain inside organs
normal blood flow
Normal organ functions
No pain
The shape of the Mutated H.B. effects the makeup of the red blood cell.
(Shown in next slide)
Affected individual-
Sickle Shaped
The blood clumps and flows abnormally through the blood stream which can lead to clotting.

Normal Individual-
Circular shaped
Blood flows normally
through bloodstream
Stats on Sickle Cell Anemia
It is estimated that:
SCD affects 90,000 to 100,000 Americans.

Relative to the rate for the period 1983 through 1986, the SCD mortality rate for the period 1999 through 2002 decreased by:

68% at age 0 through 3 years;
39% at age 4 through 9 years; and
24% at age 10 through 14 years.

Mortality Among Children with Sickle Cell Disease Identified by Newborn Screening During 1990-1994 -- California, Illinois, and New York:

SCD is a major public health concern. From 1989 through 1993, an average of 75,000 hospitalizations due to SCD occurred in the United States, costing approximately $475 million.
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