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Vascular Mechanobiology

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by

Plansky Hoang

on 24 September 2014

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Transcript of Vascular Mechanobiology

Examples could have included:
-pressure
-colliding objects
-stress
-strain
...anything involving physical contact

The forces we will focus on are shear stress and strain
What kind of forces did you think of?
Vascular
Mechanobiology
In this case, we are referring to the vascular system, which is the body's network of blood vessels.

This includes both arteries and veins of all sizes and blood flow capacities.
Vascular

Mechanobiology
Vascular Mechanobiology
There are many types of cells that make up a blood vessel, but the ones we will focus on help form the vessel walls.

One major component is a single layer of cells, made up of endothelial cells, that coat the inner vessel walls. Beyond that, layers of smooth muscle cells are critical to the strength and elasticity of the vessels.

These traits help vessels respond to mechanical changes that we will now explore
Video
->The study of how cells and tissues respond to mechanical forces.


Shear Stress- A force on the blood vessel caused by blood flow. This causes a biological response known as vasodilation causing the blood vessel to widen.
Examples of How Cells Respond to...
Learning Objectives
We know cells can communicate through electrical and chemical signals, like in the nervous system or by hormones,

But what about mechanical signals?

What types of possible mechanical signals (or forces) can you think of?


In order to gain a better understanding,
let's split up the terms
Bringing terms together...
The study of how cells in the vascular system are affected by the mechanical forces imposed on them
Vascular Mechanobiology
is....

To understand the concept of mechanobiology and it's role in components of the cardiovascular system
Be able to give an example of how vascular cells react to mechanical forces
Strain- Also known as circumferential stretch, blood pressure pushes perpendicular to the blood flow. This causes mechanical distention, physically increasing the size of
the blood vessel.
On the left is a simplistic view of a vessel and to the right is the vascular network throughout the entire body
Endothelial Example
Smooth Muscle Example
Wrap up...
View from 1:00 to 1:53

Arterial remodeling: the artery walls will recognize the required amount of force to deliver the required blood flow rate, therefore it will remodel itself to maintain a target value of shear stress
Cells that are exposed to a stretching device will grow more quickly than smooth muscle cells that are grown under normal static conditions
We have determined that mechanical forces can influence a biological response from different tissues in the cardiovascular system. These forces involve shear stress, stretch/strain conditions, and other mechanical processes, which all effect the vascular system in differing ways to maintain overall stability.
Undergraduate Group 3
References:

1. Ethier, C., & Simmons, C. (2007). Introductory Biomechanics: From Cells to Organisms (1st ed.). Cambridge: Cambridge University Press.

2. Background Image: http://ak4.picdn.net/shutterstock/videos/797740/preview/stock-footage-high-quality-d-animated-render-of-red-blood-cell-in-human-blood-vessel-created-using-maya-and.jpg

3. Youtube Video: www.youtube.com/watch?v=P5_nQ_Zd2ss

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-http://wiki.district87.org/images/5/55/Vascular.jpg
-http://physiologyonline.physiology.org/content/nips/21/6/388/F2.large.jpg
-http://www.nature.com/nrn/journal/v13/n12/images/nrn3383-f4.jpg
www.youtube.com/watch?v=P5_nQ_Zd2ss
"http://johnny625.files.wordpress.com/2013/02/circulatory_system.gif"
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1. See reference page
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Full transcript