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Transcript of Dentinogenesis Imperfecta
"genetic disorder of tooth development”
Discovered by Dr. Barret in 1882, named by Robert and Schour in 1939
Affects 1 in every 6-8,000 births
Indirectly affects the whole health
Decreased size due to attrition
Roots are narrow
Crowns are bulbous
Originated in 1973
Classifies according to cause and appearance
Not accepted by all dentists
Correlated with Osteogenesis Imperfecta (OI)
Least severe out of the 3 divisions
*More effect on primary teeth
*Roots are "tapered"
Most common type of bone disorder
*Blue eye sclera
Caused on mutation on COL1A1 and COL1A2
*Genes are responsible for Type 1 collagen
Type 1 collagen is responsible for dentine
Dentine composed of:
*70% Mineral, 20% Organic, 10% Water
Case Study of DGI I with OI
Teixiera, Monti, Barron
Most common type of DGI
Affects between 1 in every 6-8,000 births in the U.S.
*Similar to DGI I
*No normal teeth visible
Zhang, Acevedo, Barron
Discovered in 2001
Expressed in other parts of the body
"Most abundant, non-collagenous protein in dentin"
Secreted by odontoblasts
"Cleaved" into 3 separate proteins
*DSP, DGP, DSP
Hotspots: Exons 2 and 3
Zhang, Kim, McKnight
Extremely similar to DGI II
Found in "Brandywine isolate"
* Similar to DGI II
* "Shell teeth"
Zhang, Kim, Neeti
Diagnosis detection comes with benefits
Objectives in early diagnosis:
*More treatment options available
*Less psychological troubles
*Physical characteristics are suppressed
Depend on severity and progression of scenario
Early diagnosis in primary teeth and mild cases:
Late diagnosis in permanent teeth:
*porcelain jacket crowns
*removable or permanent prosthesis
Decreased pain for resorations
Understanding dentin formation
Early prevalence and treatment is key
Dentists are looking for better options and understanding of DGI
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