Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Dentinogenesis Imperfecta

No description
by

Lluvia Barragan

on 8 November 2011

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Dentinogenesis Imperfecta

Dentinogenesis Imperfecta
DGI II
Future Studies
DGI III
Introduction
Prevalence
DGI I
Summary
Abbreviated DGI
"genetic disorder of tooth development”
Discovered by Dr. Barret in 1882, named by Robert and Schour in 1939
Affects 1 in every 6-8,000 births
Indirectly affects the whole health


Teixeira, Neeti
Dentinogenesis Imperfecta
Appearance Characteristics
Discoloration/Transparent
Amber-like tint
Decreased size due to attrition
Roots are narrow
Crowns are bulbous






Teixeira, Neeti
Shields' Classification
Originated in 1973
Classifies according to cause and appearance
Categorized into:
*DGI I
*DGI II
*DGI III
Not accepted by all dentists
Correlated with Osteogenesis Imperfecta (OI)
Least severe out of the 3 divisions
Appearance:
*"Amber" tint
*Size abrasion
*More effect on primary teeth
*Roots are "tapered"
*Pulp exposure

Teixeira, Barron
Osteogenesis Imperfecta
Most common type of bone disorder
Characteristics:
*Blue eye sclera
*Brittle/fragile bones
*Bone deformation
Caused on mutation on COL1A1 and COL1A2
*Genes are responsible for Type 1 collagen
Type 1 collagen is responsible for dentine
Dentine composed of:
*70% Mineral, 20% Organic, 10% Water




Case Study of DGI I with OI

Teixiera, Monti, Barron
Most common type of DGI
Affects between 1 in every 6-8,000 births in the U.S.
Appearance:
*Similar to DGI I
*No normal teeth visible
*Bulbous crowns





Zhang, Acevedo, Barron
DSPP Gene
Discovered in 2001
Labeled 4q21
Expressed in other parts of the body
"Most abundant, non-collagenous protein in dentin"
Secreted by odontoblasts
"Cleaved" into 3 separate proteins
*DSP, DGP, DSP
Hotspots: Exons 2 and 3

Zhang, Kim, McKnight
Extremely similar to DGI II
Found in "Brandywine isolate"
Appearance:
* Similar to DGI II
* "Shell teeth"


Zhang, Kim, Neeti
Autosomal dominant
Diagnosis detection comes with benefits
Objectives in early diagnosis:
*More treatment options available
*Less psychological troubles
*Physical characteristics are suppressed



Neeti, Sapir
Treatments
Depend on severity and progression of scenario
Early diagnosis in primary teeth and mild cases:
*crown placement
*veneers
*dental implants
Late diagnosis in permanent teeth:
*porcelain jacket crowns
*implants
*overdentures
*removable or permanent prosthesis

Neeti
Restoration retention
Decreased pain for resorations
Understanding dentin formation


Neeti, Yamakoshi
Early prevalence and treatment is key
Dentists are looking for better options and understanding of DGI

THANK YOU FOR YOUR ATTENTION!!!
Full transcript