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Pengaruh Okra (Abelmoschus esculentus) terhadap Diabetes Mel

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Melisa Putri

on 20 November 2014

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Transcript of Pengaruh Okra (Abelmoschus esculentus) terhadap Diabetes Mel

Latar Belakang :
Penderita DM di (WHO) = 347 juta orang
Indonesia (Riskesdas) = DM kelompok usia 45 - 54 tahun di perkotaan.
Okra (Abelmoschus esculentus) telah lama dibudidayakan di Indonesia, namun kurang disosialisasikan manfaatnya

Bab I : Pendahuluan
Bab V : Pembahasan
Penelitian
In Vitro
Bab VI : Kesimpulan dan Saran
Kesimpulan :
Komponen-komponen dalam okra yang berperan dalam penurunan kadar glukosa darah :
Quercetin-3-O-beta-D-glucopyranosyl-(1→6)-beta-D-glucopyranoside
Quercetin-3-O-beta-D-4"-O-methyl-beta-D-glucopyranoside
Viscous Soluble Dietary Fibers (VSDF)


Bab II : Tinjauan Pustaka
Diabetes Melitus : penyakit kronik yang terjadi karena kurangnya hormon insulin / terjadi resistensi insulin.
Melisa Putri
2011-060-091

Pengaruh Okra (Abelmoschus esculentus) terhadap Diabetes Melitus
Perumusan Masalah :
Bagaimana pengaruh okra (Abelmoschus esculentus) terhadap diabetes melitus?

Tujuan Penulisan
Tujuan Umum :
Mengetahui pengaruh okra (Abelmoschus esculentus) terhadap diabetes melitus

Tujuan Khusus :
Mengetahui zat yang terkandung dalam okra (Abelmoschus esculentus) yang berperan dalam penurunan gula darah
Mengetahui mekanisme zat-zat yang terdapat dalam okra (Abelmoschus esculentus) dan hubungannya dengan pengobatan diabetes melitus.
Manfaat Penulisan
Akademik : menambah pengetahuan akademis tentang okra dan mengurangi prevalensi diabetes melitus
Masyarakat : menambah pengetahuan masyarakat akan okra, yang mudah ditemukan di pasar dengan harga yang murah, sebagai pengobatan alternatif diabetes melitus
Penelitian : dapat dikembangkan sebagai bahan masukan untuk melakukan penelitian
Bab III : Hipotesis
Okra (Abelmoschus esculentus) dapat digunakan sebagai terapi diabetes melitus.

Bab IV : Metodologi Penelitian
2010 - 2014
Okra
Abelmoschus eschulentus
Diabetes mellitus
Hypogycemia effect.

Asian Pacific Journal of Tropical Biomedicine
Bangladesh Pharmaceutical Journal
International Journal of Pharmacy and Pharmaceutical Sciences
Journal of Ayurveda & Integrative Medicine
International Journal of Scientific & Technology Research
World Journal of Pharmaceutical Sciences
Asian Journal of Clinical Nutrition, The Journal of Phytopharmacology
International Journal of Pharmaceutical and Biomedical Research

Mekanisme antidiabetik okra adalah menghambat kerja enzim alpha-glukosidase dan alpha-amilase, meningkatkan sensitivitas sel terhadap insulin dan meningkatkan insulin signalling.

Okra juga berpotensi untuk mencegah ulkus diabetik.

Masih terdapat kontroversi mengenai toksisitas kronis okra.

Penelitian Sabhita et al (2012)
Penelitian Pada Tikus
Penelitian Saha et al (2011)
Penelitian Sabitha et al (2012)
Penelitian Subrahmanyam et al (2011)
Penelitian Rahman et al (2011)
Studi Toksisitas
Saran :
1. Perlu diadakan penelitian lebih lanjut mengenai :
Efek hipoglikemia okra pada manusia.
Dosis optimal okra untuk pengobatan diabetes melitus.
Efek samping dari konsumsi okra yang berkepanjangan pada manusia.
Dosis toksik okra yang menyebabkan timbulnya efek samping yang tidak diinginkan.
Perbandingan antara okra dengan obat golongan inhibitor enzim alpha-glukosidase.
Interaksi okra dengan obat antidiabetik lainnya.
2. Melalui studi pustaka ini, penulis melihat banyak
manfaat baik dan efek samping yang minimal dari
okra. Penulis berharap okra dapat digunakan
sebagai salah satu terapi komplementer bagi
penderita diabetes melitus.
Tatalaksana Diabetes Mellitus :
Non Farmakologi
Farmakologi
- Insulin
- Obat Antidiabetik Oral
Golongan sulfonilurea
Golongan meglitinid
Golongan biguanid
Golongan tiazolidinedion
Golongan inhibitor DPP-4
Golongan reseptor agonis GLP-1
Golongan penghambat enzim alpha-glukosidase
Okra (Abelmoshus eschulentus)
Fungsi Okra :
Bahan makanan dan pengental masakan
Obat tradisional :
- Menurunkan kadar
glukosa dalam darah
- Menurunkan kadar
kolestrol dalam darah
- Antimikrobial
- Antioksidan
- Antikanker

Daftar Pustaka
1. Diabetes mellitus [Internet]. WHO. [cited 2013 Oct 21]. Available from: http://www.who.int/mediacentre/factsheets/fs138/en/
2. Diabetes [Internet]. Mayo Clinic. [cited 2013 Oct 21]. Available from: http://www.mayoclinic.com/health/diabetes/DS01121/DSECTION=risk-factors
3. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes. Diabetes Care. 2004 May;27(5):1047–1053
4. Diabetes [Internet]. WHO. [cited 2013 Oct 21]. Available from: http://who.int/mediacentre/factsheets/fs312/en/index.html
5. Tahun 2030 Prevalensi Diabetes Melitus Di Indonesia Mencapai 21.3 Juta Orang [Internet]. Kementerian Kesehatan Republik Indonesia. [cited 2013 Oct 21]. Available from: http://www.depkes.go.id/index.php/berita/press-release/414-tahun-2030-prevalensi-diabetes-melitus-di-indonesia-mencapai-213-juta-orang.html
6. Tripathi KK, Govila OP, Warrier R, Ahuja V. Series of Crop Specific Biology Documents: Biology of Abelmoschus esculentus L. (Okra). Department of Biotechnology, Ministry of Science and Technology & Ministry of Environment and Forests Government of India; 2011
7. Olivera DF, Mugridge A, Chaves AR, Mascheroni RH, Viña SZ. Quality Attributes of Okra (Abelmoschus esculentus L. Moench) Pods as Affected by Cultivar and Fruit Size. Journal of Food Research. 2012 Oct 30;1(4):224–235
8. Okra Seeds in the Management of Diabetes. Natural Product Radiance. 2003 Nov;2(6):330
9. Tyasningsiwi RW. Okra si Lady’s Finger Hortikultura [Internet]. Direktorat Perlindungan Hortikultura Kementerian Pertanian Republik Indonesia; [updated 2012 Dec 20, cited 2013 Oct 21]. Available from: http://ditlin.hortikultura.deptan.go.id/index.php?option=com_content&view=article&id=38:okra-si-ladys-finger&catid=19:berita-terbaru
10. Moore KL, Dalley AF, Agur AMR. Clinically Oriented Anatomy. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010
11. The Pancreas [Internet]. Johns Hopkins Medicine: The Sol Goldman Pancreatic Cancer Research Center; [updated 2012 Dec 11, cited 2014 Oct 31]. Available from: http://pathology.jhu.edu/pancreas/BasicOverview2.php?area=ba
12. Longnecker, D. Anatomy and Histology of the Pancreas [Internet]. The Pancreapedia: Exocrine Pancreas Knowledge Base; [updated 2014 Mar 21, cited 2014 Oct 31]. Available from: http://www.pancreapedia.org/reviews/anatomy-and-histology-of-pancreas
13. The Pancreas and Its Functions [Internet]. The Pancreas Centre. [cited 2014 Oct 31]. Available from: http://pancreasmd.org/education_home.html
14. Motta PM, Macchiarelli G, Nottola SA, Correr S. Histology of the exocrine pancreas. Microsc Res Tech. 1997 Jun 1-15;37(5-6):384–398
15. Wittingen J, Frey CF. Islet concentration in the head, body, tail and uncinate process of the pancreas. Ann Surg. 1974;179:412–414
16. Eroschenko VP. diFiore’s Atlas of Histology with Functional Correlations. 11th ed. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 314-329
17. Cabrera O, Berman SM, Kenyon NS et al. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA. 2006;103:2334-2339
18. Islet of Langerhans Cells [Internet]. [cited 2014 Apr 16]. Available from: http://web.campbell.edu/faculty/nemecz/308_lect/lect6/fig01.jpg
19. Insulin [Internet]. Medscape. [cited 2014 Apr 16]. Available from: http://emedicine.medscape.com/article/2089224-overview#a30
20. Krahl ME. Endocrine Function of the Pancreas. Annual Review of Physiology. 1974 Mar;36:331-360
21. Biosynthesis of Insulin [Internet]. Medscape. [cited 2014 Apr 16]. Available from: http://www.medscape.com/viewarticle/726747_2
22. Duckworth WC, Bennett RG, Hamel FG. Insulin Degradation: Progress and Potential. Endocrine Reviews. 1998 Oct;19(5):608–624
23. Stöckli J, Fazakerley DJ, James DE. GLUT4 exocytosis. Journal of Cell Science. 2011;124:4147–4159
24. Insulin Action on Peripheral Cells [Internet]. [cited 2014 Oct 31]. Available from: http://medicinexplained.blogspot.com/2011/08/insulin-action-on-peripheral-cells.html
25. Sherwood L. Human Physiology From Cells to Systems. 7th ed. Canada: Brooks/Cole; 2010. p. 714-724
26. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2010 Jan;33 Suppl 1:S62–S69
27. Inzucchi SE. Diagnosis of Diabetes. New England Journal of Medicine 2012 Aug; 367:542-550
28. Konsensus Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia. PERKENI; [updated 2011, cited 2014 Oct 31]. Available from: http://www.academia.edu/4053787/Revisi_final_KONSENSUS_DM_Tipe_2_Indonesia_2011
29. HbA1c and other diabetes markers [Internet]. Hytest. [cited 2014 Oct 31]. Available from: https://www.hytest.fi/resources/product-info/hba1c-and-other-diabetes-associated-markers
30. The top 10 causes of death [Internet]. WHO; [updated 2014 May, cited 2014 Oct 31]. Available from: http://www.who.int/mediacentre/factsheets/fs310/en/
31. Holt RIG. Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatrists. The British Journal of Psychiatry. 2004;184:s55-s63
32. Dahlquist G. The aetiology of type 1 diabetes: an epidemiological perspective. Acta Paediatr Suppl. 1998 Oct;425:5-10
33. Robles, YHK, Edwards AGK, Cannings-John, R, Butler, C. Health education for diabetes mellitus type 2 in ethnic minority groups (protocol). The Cochrane Library. 2007;2:1-16
34. Vlad A, Timar R. Pathogenesis of Type 1 Diabetes Mellitus: a Brief Overview. Rom J Diabetes Nutr Metab Dis. 2012;19(1):67-72
35. Ozougwu JC, Obimba KC, Belonwu CD, Unakalamba CB. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. Academic Journals. 2013 Sep;4(4):46-57

36. Jones RE, Brashers VL, Huether SE. Alterations of Hormonal Regulations. In: McCance KL, Huether SE, editors. Pathophysiology The Biologic Basis for Disease in Adults and Children. 6th ed. Missouri: Mosby Elsevier; 2010. p. 745-764
37. Jones H, Berard LD, MacNeill G, Whitham D, Yu C. Self-Management Education. Canadian Journal of Diabetes. 2013 Apr;37 Suppl 1:s26-s30
38. Dworatzek PD, Arcudi K, Gougeon R, Husein N, Sievenpiper JL, Williams SL. Nutrition Therapy. Canadian Journal of Diabetes. 2013 Apr;37 Suppl 1:s45-s55
39. Sigal RJ, Armstrong MJ, Colby P, Kenny GP, Plotnikoff RC, Reichert SM, et al. Physical Activity and Diabetes. Canadian Journal of Diabetes. 2013 Apr;37 Suppl 1:s40-s44
40. Suherman SK. Insulin dan Antidiabetik Oral. In: Gunawan SG, Nafrialdi RS, Elysabeth, editors. Farmakologi dan Terapi. 5th ed. Jakarta: Balai Penerbit FKUI; 2009. p. 481–495
41. Harper W, Clement M, Goldenberg R, Hanna Amir, Main A, Retnakaran R, et al. Pharmacologic Management of Type 2 Diabetes. Canadian Journal of Diabetes. 2013 Apr;37 Suppl 1:s61-s68
42. Ashcroft FM. Mechanisms of the glycaemic effects of sulfonylureas. Horm Metab Res. 1996 Sep;28(9):456-463
43. Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K. Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. Journal of Pharmacology and Experimental Therapeutics. 2007 Jul;322(1):1-7
44. Pernicova I, Korbonits M. Metformin—mode of action and clinical implications for diabetes and cancer. Nature Reviews Endocrinology 2014;10:143–156
45. Ciaraldi T, Henry RR. Thiazolidinediones and their effects on glucose transporters. European Journal of Endocrinology. 1997;137:610–612
46. Ibrahim R. Diabetes Mellitus Type II: Review of Oral Treatment Options. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2 Suppl 1:21-30
47. DPP-4 Inhibitors [Internet]. Diabetes.co.uk. [cited 2014 Oct 31]. Available from: http://www.diabetes.co.uk/diabetes-medication/dpp-4-inhibitors.html
48. Holst JJ. The physiology of glucagon-like peptide 1. Physiol. Rev. 2007 Oct;87(4):1409–1439
49. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344:d7771
50. Benchasri S. Okra (Abelmoschus esculentus (L.) Moench) as a Valuable Vegetable of the World. Ratar. Povrt. 2012;49:105-112
51. Tanaman Okra [Internet]. [cited 2014 Apr 16]. Available from: http://photos1.blogger.com/hello/5/2980/640/vh2006%2520042.jpg
52. Vayssade M, Sengkhamparn N, Verhoef R, Delaigue C, Goundiam O, P. Vigneron P, et al. Antiproliferative and proapoptotic actions of okra pectin on B16F10 melanoma cells. Phytotherapy Research. 2010;24:982-989
53. Ngoc TH, Ngoc QN, Van ATT, Phung NV. Hypolipidemic Effect of Extracts from Abelmoschus esculentus L. (Malvaceae) on Tyloxapol-Induced Hyperlipidemia in Mice. Mahidol University Journal of Pharmaceutical Sciences. 2008;35(1-4):42–46.
54. Liao H, Liu H, Yuan K. A new flavonol glycoside from the Abelmoschus esculentus Linn. Pharmagnosy Magazine. 2012;8:12-5
55. Lengsfeld, C, Titgemeyer F, Faller G, Hensel A. Glycosylated compounds from okra inhibit adhesion of Helicobacter pylori to human gastric mucosa. Journal of Agricultural Food Chemistry. 2004;52(6):1495-1503
56. Aslan M, Sezik E, Yeşilada E. Effect of Hibiscus esculentus L. seeds on blood glucose levels in normoglycaemic, glucose-hyperglycaemic and streptozotocin-induced diabetic rats. Gazi Universitesi Eczacilik Fakultesi Dergisi. 2003;20:1-7
57. Tentang Tanaman Okra [Internet]. Agroklinik. [cited 2014 Nov 2]. Available from: http://agroklinik.wordpress.com/produk-2/tentang-tanaman-okra/
58. Sabitha V, Panneerselvam K, Ramachandran S. In vitro α-glucosidase and α-amylase enzyme inhibitory effects in aqueous extracts of Abelmoscus esculentus (L.) Moench. Asian Pacific Journal of Tropical Biomedicine. 2012:S162–S164
59. Khatun H, Rahman A, Biswas M, Islam AU. In vitro Study of the Effects of Viscous Soluble Dietary Fibers of Abelmoschus esculentus L in Lowering Intestinal Glucose Absorption. Bangladesh Pharmaceutical Journal. 2010 Jul;13(2):35–40
60. Khatun H, Rahman A, Biswas M, Islam AU. Water-soluble Fraction of Abelmoschus esculentus L Interacts with Glucose and Metformin Hydrochloride and Alters Their Absorption Kinetics after Coadministration in Rats. ISRN Pharmaceutics. 2011:1–5
61. Zhang ZL. Antioxidative and Glucose Homeostatic Effects of Extracts and Isolated Components from Okra (Abelmoschus esculentus Fruits). [Taiwan]: Tunghai University; 2014
62. Kumaran MS, Sivaselvi P, Brindha P, Vimala T. Molecular docking studies of abelmoschus esculentus for anti diabetics and anti inflammatory. World Journal of Pharmaceutical Sciences. 2014; 2(3): 253-258
63. Saha D, Jain B, Jain VK. Phytochemical Evaluation and Characterization of Hypoglycemic Activity of Various Extracts of Abelmoschus esculentus linn Fruit. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3 Supp 2:183–185
64. Sabitha V, Ramachandran S, Naveen KR, Panneerselvam K. Investigation of in vivo antioxidant property of Abelmoschus esculentus (L) moench. fruit seed and peel powders in streptozotocin-induced diabetic rats. Journal of Ayurveda & Integrative Medicine. 2012 Oct-Dec;3(4):188–193
65. Perez JRT, Baritua RJ, Pacalna MO, Malayao jr. SO. Exploratory Investigation On The Hypoglycemic Effect Of Abelmoschus Esculentus In Mice. International Journal of Scientific & Technology Research. 2013 Nov;2(11):249–253
66. Subrahmanyam GV, Sushma M, Alekya A, Neeraja C, Harsha HSS, Ravindra J. Antidiabetic Activity of Abelmoschus esculentus Fruit Extract. International Journal of Research in Pharmacy and Chemistry. 2011;1(1):17-20
67. Rahman F, Fatema K, Rahim ATMA, Ali L. Glucose, Insulin, and Non Esterified Fatty Acid Responses to Ladies Finger and Pointed Gourd in Type 2 Diabetes Mellitus. Asian Journal of Clinical Nutrition. 2011;3(1):25-32
68. Kumar S. Physicochemical, Phytochemical and toxicity studies on gum and mucilage from plant Abelmoschus esculentus. The Journal of Phytopharmacology. 2014 May-Jun; 3(3): 200-203
69. Ilango KB, Pradeep Rajkumar LA, Vetrivel D, Brinda P, Manisha M. Safety Evaluation of Abelmoschus esculentus Polysaccharide. International Journal of Pharmaceutical Sciences Review and Research. 2011 Sep-Oct;10(2):106-110
70. Umoh I, Oyebadejo S, Bassey E, Nnah U. Chronic consumption of combined extracts of Abelmoschus esculentus and Piper guineense induced hepatoxicity in Wistar rats: Histopathological study. International Journal of Pharmaceutical and Biomedical Research. 2013;4(2):73-77

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