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Cervical Intraepithelial Neoplasia

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Alana Perusse

on 5 March 2015

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Transcript of Cervical Intraepithelial Neoplasia

Cervical Intraepithelial Neoplasia
Alana Perusse
Tamara Mascarenhas
Aleena Rahat
Etiology and Risk Factors
The ultimate cause of CIN is not known.
However, most cases are caused by high risk HPV infections.
HPV types
Risk factors
HPV 16
HPV 18
HPV 31
HPV 33
HPV 34
HPV 39
HPV 45
HPV 51
HPV 52
HPV 58
HPV 66
HPV 68
Sexual intercourse at an early age
Multiple sexual partners
Other STDs such as herpes, syphillis
Tobacco smoke
Giving birth at an early age
Low socioeconomic status
Long term oral contraceptive use
75% of Canadians will acquire at least one HPV infection in their lifetime
23% of women under the age of 21 have CIN
80% of CIN worldwide is in developing countries
An estimated 1,500 Canadian women are diagnosed with cervical cancer each year while 580 women die from cervical cancer
Worldwide, there are ~450,000 new cases and 250,000 deaths each year from cervical cancer, making it the fourth most common cancer in women.
Cervical Intraepithelial Neoplasia

HPV Structure
Cervical Punch Biopsy
Cone biopsy
What is
E6 and E7
LEEP Procedure
How is it done?
The Bethesda System
Cervical Intraepithelial Neoplasia
Gardasil® for the prevention of infection caused by HPV types 6, 11, 16 and 18

Cervarix™ for the prevention of infection caused by HPV types 16/18

Prognostic Risk Factors

• Women over the age of 45
• Women that smoke tobacco
• Women that have positive surgical margin post surgical intervention
• Women that have HPV-16 strain

The Pap Test
This test is named after Dr. George Papanicolaou, who developed the test
The procedure is the removal of a small sample of cells from the cervix, to be examined under a microscope
The Pap Test is the most common method of screening for precancerous conditions of the cervix and cervical cancer
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Two year disease free survival rate
Picture references
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