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Barriers to participation in clinical trials of cancer

Pamela Tan

on 21 April 2011

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Transcript of CCNM

Numerous factors were reported as barriers to participation in cancer-related trials. However, only 20 of the studies reported statistically significant associations between hypothesized barriers and enrollment. The available evidence had limitations in quality regarding representativeness, justification of study methods, the reliability and validity of data-collection methods, potential for bias, and data analysis. The results indicated that underrepresented populations face numerous barriers to participation in cancer-related trials. The current systematic review highlighting the literature on recruitment of underrepresented populations to cancer trials and may be used as the evidence base toward developing an agenda for etiologic and intervention research to reduce the disparities in participation in cancer-related trials. CCNM is constantly finding new ways to improve their research on the effects of naturopathic medicine on acute and chronic health conditions. One of their more important studies involves enrolling participants for clinical tests for cancer... Racial and ethnic minorities, older adults, rural residents, and individuals of low socioeconomic status are underrepresented among participants in cancer-related trials. The authors conducted a systematic review to determine the barriers to participation of underrepresented populations in cancer-related trials.

Their search included English-language publications that reported original data on the recruitment of underrepresented groups to cancer treatment or prevention trials between 1966 and December 2005 in multiple electronic databases. They also hand-searched titles in 34 journals from January 2003 to December 2005 and they examined reference lists for eligible articles. But not everyone who gets cancer will die from it! And everyone knows how big of a deal cancer can become in somebody's life... Millions of people alive today have a history of cancer, and its all because they had successful treatments from years of continuous research. Cancer has become an ongoing health problem, like high blood pressure or diabetes. And to them, the comfort of the volunteers is as important as the results of their research :) CANCER > someone's life Clinical trials are held to test out and find new ways to improve treatments to prevent or diagnose diseases They are essential for the development of treatment and awareness of diseases such as cancer. Unfortunately, there are certain barriers and factors that prevent cancer patients from participating in these clinical trials. Various doctors around the world have conducted their own type of research to figure out the most common reasons. how much impact will the clinical trial will actually have how their families and physicians feel about their participation in the trials ...and their overall feeling and perception towards cancer Some of the top factors are... Surveys concerning cancer patients have had a majority express that they would be surprised if anyone participating in any experimental study was doing it for a selfless reason. It is understandable that patients are always hoping for some kind of cure, but all of us need to be aware that there is always something else out there worth living for. By making both patients and people alike aware of the possible impacts and benefits clinical trials can have on diseases, more and more people will consider or decide to participate in these trials. One person that has more of a potential influence on a patient's decision to enter a clinical trial, is a nurse. At present, most nurses aren't aware of their chance to affect a patient's decision or don't seize the opportunity. This hopefully will change in the future. To effectively improve participation in cancer clinical trials, focusing on the concerns and feedback of patients is crucial to make them more comfortable with their decision and thoroughly informing people who are going into or are planning to go into clinical trials must be of concern. Biedrzycki, B.A. U.S. National Library of Medicine, National Institutes of Health. (2010). Decision making for cancer clinical trial participation: a systematic review. (PMID: 21059572). Baltimore, MD: Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21059572 Hlubocky, F.J., Ratain, M.J., Wen, M., & Daugherty, C.K. U.S. National Library of Medicine, National Institutes of Health. (2007). Complementary and alternative medicine among advanced cancer patients enrolled on phase i trials: a study of prognosis, quality of life, and preferences for decision making. (PMID: 17290064). Chicago, IL: Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17290064 Schutta, K.M., & Burnett, C.B. U.S. National Library of Medicine, National Institutes of Health. (2000).Factors that influence a patient's decision to participate in a phase i cancer clinical trial.(PMID: 11058975). Washington, DC: Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11058975 Kohara, I., & Inoue, T. U.S. National Library of Medicine, National Institutes of Health. (2010).Searching for a way to live to the end: decision-making process in patients considering participation in cancer phase i clinical trials.(PMID: 20189911). Tokyo, Japan: Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20189911
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