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OH

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Francesco Baglivo

on 18 January 2015

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Transcript of OH

OH
HO
Can we trust research?
Francesco Baglivo
"How to publish in international journals"
The young researcher has a great idea
And so he starts up a clinical trial in a small hospital
The first idea reveals to be founded and the
study assumes a big commercial importance
Then a pharmaceutical company recruits the researcher to work for it
Let's conjecture a situation
There is a young researcher
And the researcher , no more young,
leads other studies in order to
improve the economical benefits
of his own first discovery
Subsequently other studies find out that the drug supported by our researcher is a risk factor for many diseases and the case ends up in court
Unfortunately what we only speculated is a real and not only case
Robert Lindsay in 70's discovered a correlation between menopause and osteoporosis and then began to work for the Wyeth-Ayerst Laboratories as a consultant. A few years ago Wyeth was sued for an estrogen-based drug, Prempro (which was related to the risk of breast cancer, stroke and other diseases) and the relationship between Lindsay and Wyeth became a central part of the cause.
Industry has many ways to give money to researcher
So let's investigate some
Speaker bureau
The industry finances a trip for a researcher who eventually holds a speech and shows a presentation made by marketing experts
Ghostwriting
A producer writes a draft of a paper and pays a scientist to sign it and submit it to a peer reviewed journal
Consulting arrangements
A company enrolls a researcher in order to obtain recommendations. But it doesn't need advice. In fact its real aim is being able to claim a wide range of illustrious advisors to gain visibility
Approximately one third of investigators at academic institutions have personal financial ties with industry sponsors.
A 1992 analysis of 789 articles from major medical journals found that 34% were written by lead authors with relevant personal financial interests in their research
And each one of the phenomena described is equally used
speaking engagements
consulting arrangements
34%
33%
32%
positions on advisory boards

Someone may think that commercial relations between researcher and companies are not our business since they don't compulsory lead to science failure
But many studies prove that scientists with conflict of interests are at least less credible even in bona fide . " Industry-sponsored research tends to yield pro-industry conclusions"
A study analyzed 61 nonsteroidal anti-inflammatory drug , all of which were industry-sponsored, and found that the investigational therapy was comparable with (71.4% of studies) or superior to (28.6% of studies) the comparison therapy. No studies found that the comparison therapy was superior
*randomized controlled trial
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"Scope and Impact of Financial Conflicts of Interest in Biomedical Research", Justin E. Bekelman; Yan Li; Cary P. Gross, JAMA. 2003; Jan, pp 454-465
"La ricerca farmaceutica è affidabile?" Charles Seife, Le Scienze. 2013; Feb, pp 31-39
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Thanks for your attention
Francesco Baglivo
Bibliografia
However without pharmaceutical fundings researchers wouldn't be able to translate their ideas into new drugs
So the only way to trust research is to rely on scientist honor and honesty regarding that peer reviewed journals request transparency to authors
Full transcript