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Transcript of Canine Parvovirus
There is no anti-virus, vaccines only work in prevention
Promising New Method
Virus v. Virus
Canine Parvovirus (CPV) Type 2c
Current Strategies: Advantages
Relative Mortality Rates
Early 1960's CPV-1
Stems from Feline Panleukopenia Virus
vomitting, diarrhea, lethargy
swelling of the heartmuscles
Ran ramped through kennels and pounds
Began as CPV2, now has many identifiable
Some steps are automated
High sensitivity and specificity
Expert performs tests
Easy to perform and interpret
Saves time and dependable results
Prompt, accurate, and specific
High rate of success
Requires very little antigen
Four types of test
Fast but less reliable
Only increase sensitivity
Very complex steps
Easy to follow
Increase sensitivity and specificity
Involves Direct and Indirect steps
ELISA Sandwich Test
Steps of Sandwich test
Fecal sample (Capture)
Tube A (Detect)
Observe results: color change in tube B
First found in animal fecal and fluids
Discovered as an affliction in 1920
Transferred through fecal matter and fluids
Virus has a long life, very durable
Infects intestinal crypts, lymphatic tissue,
and cardiac muscle
The survival rate of the animal will depend on how quickly the CPV is diagnosed, treated, and what type of treatment is used. Currently, the most common and effective treatment is done with the hospitalization of the dog.
Two Main Types of Care
Keeping the dog hydrated is key to upping survival odds.
Blood Plasma Transfusion
Will be from a donor dog that has survived the parvo virus .
Both Costly: Ranging from $1,500- 3,000
In Home Care
Using Maropitant (3), an anti-nausea, and Convenia (4), antibiotic for skin and urinary track infections, for at home care.
Cost of only $200- $300
Antiviral Drugs, Tamiflu. (1)
Antiviral Proteins (found in silkworm larvae), not approved for clinical use in US. (2)
Keep them hydrated, inject fluids, typically an electrolyte solution.
Keep infected puppies together.
Varying survival odds
New Study Performed By Dr. Lauren A. Sullivan at Colorado State University Veterinary Teaching Hospital
Current Strategies: Disadvantages
Requires an expert on hand
Must be done manually
Range of success variable
Parvo is incredibly resilient. Thus, the best approach is to stop infection before it happens.
Modified live virus
3 shots over 9-12 weeks
+ Booster after 1 year
Canine Adenovirus is very similar to CPV
Current study has only looked at viability in cell cultures
Still a ways away from commercial
Mutated to contain Ad-cIFN-gamma
Infected cells expressed new protein
Protein blocked CPV infection
Promising New Method
Modified E.coli that manufacture and export recognizable virus proteins
Much easier than injection
Don't need a vet
Less risk of minor infection
Only temporary immunity
Less robust immunity
(1) - http://www.aspca.org/pet-care/dog-care/parvovirus
(3) - http://www.ncbi.nlm.nih.gov/pubmed/22149493
(4) - http://www.ncbi.nlm.nih.gov/pubmed/23383512
(5) - http://www.zo.utexas.edu/faculty/sjasper/images/so23_03.gif
Weakened immune system
Congestive heart failure
By: Jacob Haws