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Transcript of Cushings syndrome
- It occurs at the result of too much cortisol in the blood for an extended amount of time .
- When in normal amounts, cortisol helps the body do a number of things. These include:
1-Responding to stress
2-Maintaining blood pressure and cardiovascular function
3-Keeping the immune system in check
4-Converting fat, carbohydrates and
proteins into energy There are two types of Cushing’ syndromes .
1- Exogenous :is when the disease is caused by factors outside the body
2-endogenous. This is the name for when the disease is caused by factors from within the body.
The symptoms for both of them are the same. Exogenous Cushing’s syndrome
-the most common.
-found in people taking cortisol-like medication .
-This type of Cushing’s syndrome is temporary and goes away right after the patient finishes taking the medication. Endogenous Cushing’s syndrome
1- tumor in pituitary or adrenal gland
-pituitary gland : excessive production of ACTH "posterior pituitary gland",which stimulates the adrenal gland to secrete cortisol
-adrenal gland : direct excessive production of cortisol
3-sometimes tumours not in the pituitary, usually in the lungs, can also produce too much ACTH and cause Cushing’s syndrome. This disease results in a number of physical and mental changes in the body and mind of the person who has got the disease. -Weight gain, especially in the upper body 1-Rounded face and extra fat on the upper back and above the collarbones 2-High blood sugar (diabetes) 3-High blood pressure (hypertension) 4-Thin bones (osteoporosis) 5-Thin, fragile skin that bruises easily 6-Purple-red stretch marks (usually over the abdomen and under the arms) 7-Depression and difficulties thinking clearly 8-Too much facial hair in women 9-mental abnormality as insomnia ,euphoria & psychosis 10-polycythaemia with in basophil, eosinphil & lymphocytes treatment it depends on the cause Exogenous Cushing’s syndrome slowly disappears after the affected finishes taking the cortisol-like medications Their doctors will tell them the appropriate time to either slowly decrease the medication or stop using it. For Endogenous Cushing’s syndrome,
1- the first step in treatment is usually surgery to remove the tumour which causes the high levels of cortisol
2-some people have to take medication which helps reduce cortisol .
3- radiation therapy to destroy remaining tumour cells.
4-Some people must have both adrenal glands removed to control Cushing’s syndrome physiology department thank you section dr:
DR. Abd El-Aziz Head of department:
DR. Hanaa Abd Elmen'm -Ahmed Elboraey