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Inflammation the Secret Killer

Glutathione, Inflammation, Immune function,
by

Jose O Seda

on 14 August 2013

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Transcript of Inflammation the Secret Killer

Inflammation: the Secret Killer
What can we do to
treat the
root causes?
Turmeric (Curcumin)
Alpha Lipoic Acid
Quest for the source of illness





Decrease inflammation and oxidative stress
Limit
toxin
exposure and
detoxify
Optimize
nutrition
(Organic Whole Foods)
Supplement
deficiencies (Vitamins, Minerals, Amino Acids, Essential Fatty Acids)
Improve
GI health
(i.e. Probiotics, DEs)
Improve
sleep
(sleep hygiene, melatonin, hormones)
Optimize
immune function
(deficiencies and nutrition)
Balance
hormones
(check them first)
Optimize
Mitochondria
(makes energy from food, powerhouse of the cell)
Stress
management, mood
Exercise
There is!

ANTIOXIDANTS
Probably the main antioxidant
after Glutathione
Mainly known for tx of
DM
and Neuropathy
Works in both fatty and watery tissues
Generates and
recharges Glutathione
Also recycles CoQ10, Vit C and E,
Regenerates
Mitochondria
ATP
One of the best
Chelators
of Heavy Metals
Increases Cardiac Output and Blood Flow
Used to
reverse
Lupus, Rheumatoid Arthritis and other
autoimmune diseases
On Animal models:
Shown to
prolong life

Prevent cancers (skin and GI)
Prevents Obesity and Diabetes
Reverses plaque in the brain
Anti-inflammatory
Raises Testosterone
Antiviral
Depression
Anti-aging, Regenerative
and Functional Medicine
Chronic Diseases
Obesity
Mind
Holistic/
Integrative Medicine
"This concept is so intriguing because it suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three."
TIME Magazine 2004
1. Optimize your own body's healing capabilities.
We were
made to self heal!
Architect analogy
The problem is that we are exposed to
too much oxidative stress or too many toxins
and have poor antioxidant function
Can be overwhelmed
Resveratrol
In Humans:
Lowers blood sugar
French people have
low coronary heart disease
, despite having a diet
high in saturated fats
Overwhelming Evidence
Potent
Anti-inflammatory (as Ibuprofen)
10 X
potent than Vit E
Potent Anti Cancer at
All 6 stages
of cancer
Alzheimer, Parkinsons, prevention (reduces amyloid formation by
8 dif mechanisms
)
Stroke
recuperation, Learning
158% more energy in the brain
Improves cholesterol
Poorly absorbed
If combined with Bioperine
Is Nature's
Bioavailability
Enhancing Thermonutrient
Works at optimizing the
absorption
of other nutrients in the body.
Increases absorption of
Curcumin by %2000
in humans
In animal studies:
has shown anti-depression like activity
colon cancer prevention
lowers plasma insulin and glucose concentrations
lowers fat accumulation and improves fatty liver
Anti-bacterial, and anti-allergen
Glutathione
Per Dr Mark Hyman "It's the most important molecule you need to
stay healthy and prevent disease
..., It's the secret to prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer's disease."

"
mother of all antioxidants, the master detoxifier and maestro of the immune system
"

There are
107,843
scientific articles in PubMed

Why we have not heard of it??

Decreased
by Acetaminophen, poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation.

Spectracell
simple building blocks of protein or amino acids -- cysteine, glycine and glutamine.
The Secret of its power is the sulfur (SH) chemical groups
Is a
sticky
molecule that acts like fly paper and
all the bad things in the body stick onto it,
including free radicals and toxins like mercury and other heavy metals.



Critical for one simple reason: It
recycles
and
activates
other antioxidants (Vit C, E, ALA, CoQ10),
including itself
The most critical and integral part of your
detoxification system
(Heavy Metals, chemicals, pesticides, herbicides, solvents)
Protects from
Radiation
(25,000 Americans develop cancer yearly as a result of medical radiation exposure)
Potent anti-inflammatory (decreases CRP, NF-kappa B)
Columbia University School of Public Health estimates that
%95 of cancer is caused by diet and excessive toxins

80,000 toxic industrial chemicals found in our environment today

A CDC report resulted on 2,500 screenings of Americans for 148 industrial chemicals, and found
significant levels of the 148 on every single person tested

When does this exposure starts?
Study in 2004 in U.S. Hospitals:
Tested umbilical cord blood from 10
newborns
Tests revealed a total of 287 chemicals in the group.
Including pesticides, consumer product ingredients, and wastes from burning coal, gasoline, and garbage
we know that
180 cause cancer
in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests
900 drugs have been linked to liver damage
Even Over the Counter (OTCs)
Acetaminophen (Tylenol) is the #1 cause of acute
liver failure
in the US
We all know inflammation on the surface of the body as local
redness, heat, swelling and pain
. It is the cornerstone of the body's healing response, bringing more nourishment and more immune activity to a site of injury or infection.
But when it persists or has no purpose it damages the body and causes illness

Labs: Inflammatory markers, CRP- C-reactive-protein, TNF-A, IL-6, acute phase reactants, Sed Rate
Clinical Case:
John 52 y/o Caucasian executive comes to me
seen by the best
special-ists
on each field per him
Cardiologist- Heart attack, high cholesterol, HTN
Endocrinologist- Diabetes
Gastroenterologist- IBS, Reflux, Bloating
Psychiatrist- Anxiety, Depression, Insomnia
Internist- allergies, tiredness, his Viagra
Rheumatologist- Joint pains, swelling
Neurologist- Memory issues, Headaches
Dermatologist- Psoriasis, Hair loss
Hepatologist- Fatty Liver

Currently on
14 of the best medications
Diet- not following any
Supplements- none
Social- Very stressful life, smokes, drinks
Exercise- no time
Raised glutathione
levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development.
Increases Energy, Sleep quality, Concentration, Mental Clarity.
Linked to Parkinson's and Alzheimer's
Slows aging process
Improves Heart, Lungs, Liver, Kidneys
So how do I raise Glutathione?
Is
not absorbed
by mouth
IV Glutathione (Magic Johnson ~$3,600/month)
Topical or sublingual decreases our own production
Most people had to combine several different supplements (
NAC
85%, ALA 30-50%, Milk Thistle 35%, Selenium)
Ice cold water- Raises it 35%
Sulfur
containing foods might help (garlic, onions and the cruciferous vegetables)
Exercise
Ribo-ceine
Combines Ribose and Cysteine
RiboCeine or Rib-Cys has been the subject of
20 published,
peer-reviewed scientific studies that were funded by the NIH and other scientific institutions.
RiboCeine was developed after years of research by the renowned research scientist and medicinal chemist, Herbert T. Nagasawa, Ph.D.
Results in Liver
intracellular levels 300% above NAC
Is there a molecule/s
that would help with most of the root causes of illness?
What was I doing for prevention?
Anti- inflammatory diet,
AOAP (As Organic As Possible)
Exercising
For Anti-aging, Cancer and chronic illness prevention:
Absorbable Multivitamins, Vit D,
Omega 3 (Fish oil, Krill, Flax)
Probiotics
Magnesium Malate, SAS, Cellgevity, ATP, Berberine,
Turmeric/black pepper
Resveratrol, Turmeric, Quercetin, Alpha-lipoic Acid, Detox Shakes...

Because:
My Cholesterol was
210
, when I was 10 yrs
My GM had her first Heart Attack at 38
My dad had his Heart Attack at 42
I was
pre-diabetic
and
pre-hypertensive
Was 25 Lbs above my goal
Had issues
sleeping, horrible muscle spasms, headaches, ADHD
CDC US 2012 Stats:
7 out of 10 deaths among Americans each year are from
chronic diseases.
Heart disease, cancer and stroke account for more than 50% of all deaths each year.
1. In 2005, 133 million Americans – almost
1 out of every 2 adults
– had at least one chronic illness.
2.
Obesity
has become an epidemic
3.
Arthritis
is the most common cause of disability,
4.
Diabetes
is the leading cause of kidney failure, and blindness among adults,
Besides that we have:
24 million with
Autoimmune

30 million
Asthma
60 million
Irritable Bowel Syndrome
Journey
Before Med School
TIP OF THE ICEBERG
The most potent of all
we make it ourselves, but
Levels fall and regardless it lowers 10-15% per decade after 21yrs old
GMOs
STRESS
HERBICIDES
TOXINS
PROCESSED FOODS
GMOs
Not everything is ORAC:
Some Anti-Oxidants last
seconds
Some work only on Fat or Aqueous
Sulforaphane: One of the longest lasting antioxidants known (3 days)
There is also the Inflammation Factor
Among multiple other nutrients
The key is to get as much Variety as possible
Synergism
Rotation
The deeper we get the more complicated:
Isothiocyanates, Flavonoids, Plant alkaloids, Isoflavones, Tannins, Polyphenols, Anthocyanins, Carotenoids... Still discovering
Most common known:
Vit A, Bs, C and Vit E
Selenium
CoQ10
L-carnitine
Zinc
We have ~ 10 trillion cells in our body
Each cell is estimated to get around
10,000-100,000
free radical hits
a day
Full transcript