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Bèta-glucanen

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Lisa Hulshof

on 11 November 2013

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Transcript of Bèta-glucanen

Bronnen
Het effect van bèta-glucanen op het immuunsysteem
Inhoud
Inleiding
Aangeboren immuunsysteem
Verworven immuunsysteem
Bèta-glucanen en kanker
Bèta-glucanen en bovenste luchtweg infecties
Conclusie en advies
Bronnen
Inleiding
1,3-, en 1,6-bèta-glucanen; gist, schimmels en paddestoelen
1,4-bèta-glucanen ; haver


complexiteit; immunomodulerend


opname: M-cellen in platen
van Peyer


Receptoren
PAMP's= pathogen associated molecular patterns

PRR's= paternn recognation receptors:

- scavenger receptoren
PI3K, Akt en MAPK pathway

- lactosylceramide
NF-κB productie--> TNF-α
productie
neutrofiele chemotaxis


Verworven immuunsysteem
Ontwikkeling T-lymfocyten: o.i.v. TGF-bèta


celsignalen: apoptose, celcyclus, groei en overleving


TbètaRIII= bèta-glucaan: TGFbèta type III receptor
- co-receptor
- TGFbèta en inhibine


dubbel - --> dubbel +






Bronnen
Thornton BP, Vetvicka V, Pitman M, et al. Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 1996; 156:1235–1246.
Rice PJ, Kelley JL, Kogan G, et al. Human monocyte scavenger receptors are pattern recognition receptors for (1!3)-beta-D-glucans. J Leukoc Biol 2002; 72:140–146.
Zimmerman JW, Lindermuth J, Fish PA, et al. A novel carbohydrate–glycosphingolipid interaction between a beta-(1!3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes. J Biol Chem 1998;273:22014–22020.
Brown GD, Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001; 413:36–37.
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Bèta-glucanen en kanker
Anti-tumor werking:
structuur en moleculair gewicht




Effecten:
↑ proliferatie en activatie perifere bloed monocyten (borstkanker)
metastasen voorkomen (coloncarcinoom, muizen)
verbetering Quality of Life (colorectaal kanker en maagkanker )
onderdrukken bijwerkingen chemotherapie (colorectaal kanker)
toename gemiddelde overleving (acute myeloide leukemie, muizen)
Bèta-glucanen en bovenste luchtweg infecties
Rhino-, corona- en influenzavirus

1,3- en 1,6-bètaglucanen:
- verhoogde IgA saliva
- toename NK-cellen
- reductie symptomen

1,4-bèta-glucanen: geen invloed
Conclusie en advies
Effecten van bèta-glucanen (paddenstoelen en gisten):

-Aangeboren immuunsysteem:
sneller op gang brengen verworven immuunrespons
sneller klaren van pathogenen
versterken v/d intracellulaire doding van pathogenen
grotere pro-inflammatoire werking

-Verworven immuunsysteem:
rol bij ontwikkeling T-lymfocyten
moduleren diverse celsignalen
anti-virale werking

-Kanker: meer onderzoek!

-Bovenste luchtweg infecties: meer onderzoek bij gezonde individuen


Receptoren
-Complement receptor 3 (CR3)

Lectine domein
NF-kappaB activatie
chemotaxis, adhesie en transendotheliale migratie neutrofielen
doding iC3b bevattende organismen

- Dectine-1: C-type lectine

Koolhydraatherkenningsdomeinen: suikers bèta(1,3)- en bèta(1,6)-bindingen
NF-kappaB activatie
fagocytose
productie zuurstofradicalen
neutrofiele degranulatie
productie cytokinen en chemokinen.



Aangeboren immuunsysteem
Effecten bèta-glucanen:
Snellere maturatie van dendritische cellen (schimmel)
↑ productie van zuurstofradicalen in leukocyten (gist)
↑ verhoogde IFN-y productie (gist)
TNF-α productie (gist)
↑ vele cytokines (IL-1β, IL-8, IL-4, IL-12, IL-6) (paddenstoel, gist, schimmel)
↑ IL-10 productie --> moduleren immuunrespons (gist)
Aangeboren immuunsysteem
Effect bèta-glucanen:
Activatie aangeboren immuunsysteem via PRR's -->
o.a. Dectine-1

Activatie van:
- macrofagen (dectine-1)
- neutrofielen (dectine-1)
- dendritische cellen (dectine-1)
- monocyten
- NK-cellen




Muizen bèta-glucanen

4-voudige toename intraepitheliale lymfocyten darmen,

- vooral CD8+-lymfocyten

- INF-gamma productie T-lymfocyten


Schimmel: schizophyllan bij HBV:
- productie IFN-gamma verhoogt
- proliferatie van perifere bloed monunucleaire cellen
- verhoogde fagocytose


Schimmel; bij HIV:
- CD4+-toename
- CD8+ activiteit verhoogd
- activatie complement en IFN-gamma

Antivirale werking bèta-glucanen
Intra-epitheliale darmlymfocyten
Conclusie en advies
MEER ONDERZOEK! --> humane studies en verschillende bèta-glucanen


Advies:
Media belangrijk communicatiemiddel --> informeren via radio/tv/facebook/app in
samenwerking met voedingscentrum

Schijf van vijf:
(nog) geen aanpassing --> eerst meer onderzoek








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