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APL

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by

Caitlin Norsworthy

on 29 April 2010

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Transcript of APL

Acute promyelocytic leukemia commonly know as APL
APL is a malignancy
of the bone marrow
in which there is a
deficiency of mature
blood cells in the
myeloid line of cells,
and an excess of immature
cells, called promyelocytes.
signs and symptoms of
APL are nonspecific
and include fatigue
minor infections,
or a tendency to bleed.

there is usually pancytopenia,
with low levels of red blood cells
which is anemia,low levels of
granulocytes and monocytes(types
of white blood cells that fight
infection), and low levels of platelets
(that are needed for blood to clot
normally) many patients recieve
transfusions from a donor. now most APL patients
are treated with all-
trans-retinoic acid ATRA
this is a form of "differentiation
therapy" ATRA can induce a
complete remission.
however it cannot eliminate
the leukemic clone, ATRA is
therefor used in combination
with chemotherapy and an
anthracycline drug.
The prognosis for APL
depends on many factors
including the white blood cell
(WBC) count at the time of
diagnosis. 90% of patients
diagnosed with APL acheive
complete remission, but those
patients that do relapse
are treated with a drug called
arsenic trioxide, which is an
anti-cancer chemotherapy drug.
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