Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Xenotransplantation

No description
by

Kaitlin Ball

on 12 December 2013

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Xenotransplantation

Definition: Xenotransplantation is the transplantation of non-human organs, tissues and cells into human patients.
Transgenic Pigs
Decreases chance of transmitting diseases and rejection
Cons to xenotransplantation
Animal rights
Benefits to xenotransplantation
History of Xenotransplantation
Baby Fae
Non-human donor
Chimpanzee's
Xenotransplantation
Xenotransplantation
Different forms of xenotransplantation
Animal External Therapies (AET):
No specific criteria for patient
By: Connor Kaminski and Kaitlin Ball
Alexis Carrel was the founder of organ transplant, however Jaboulay was the first to transplant animal organs into humans.
Running human blood through machine containing animal liver cells.
Regrowth of human skin
Animal Cell Therapies (ACT):
Transplantation of skin, bone marrow, or clusters of specialized cells such as brain or pancreatic islet cells into a human recipient
Animal Organ Transplants (AOT) (most commonly known to public)
Transplantation of entire organs from an animal source such as, heart, lungs and kidneys into a human recipient
Compatible organ size and anatomy for human transplantation
Share many similarities with humans (very similar DNA)
Endangered species
Slow to reproduce with few offspring
Pigs:
Compatible organ size and anatomy for human transplantation
Breed quickly with many offspring
Making it accessible all around the world
Future of xenotransplantation
20-30% of patients on the waiting list for a transplant die before they receive an organ
Interesting facts
Thanks for Watching!
How its done: Doctors take an organ that was donated by an animal source (most commonly pigs are used in this process) and surgically implant it into a human recipient that needs the new organs.
Complications
Expensive
Pollution
Culturally unavailable
No shortage of organs
Temporary donor
Provide treatment for patients with Parkinson's, diabetes and Alzheimers disease
Provide skin transplants for burn victims, corneas for corneal transplant and bone transplants for limb reconstruction
Lifespan of pigs
Zoonosis/retroviruses
Primary Research Paper
Placing human genes into pig genes
Undesired pig disposed of
Gene Knockout
History or organ transplants
High risk of rejection or diseases
Whole organ transplants
Human/Animal Hybrid
human cells that are grown in control with animal cells that are then transplanted back into the human patient.
Provide patients with long term graft survival, so the patients can live a great, long life after their transplantation.
Worldwide Ban
Hyperacute Rejection
Acute Vascular Rejection
Cellular Rejection
Chronic Rejection
References
http://www.ncbi.nlm.nih.gov/pubmed/17627227
http://www.theaidsinstitute.org/node/259
http://www.cpha.ca/en/activities/xeno/science-6.aspx
http://web.ebscohost.com/src/pdf?sid=9c645678-ea42-40c5-ac0d-b47373743aca%40sessionmgr198&vid=6&hid=128
http://emedicine.medscape.com/article/432418-overview#a1
http://www.hc-sc.gc.ca/sr-sr/biotech/about-apropos/xeno-eng.php
http://www.hc-sc.gc.ca/dhp-mps/brgtherap/activit/fs-fi/xeno_fact-fait-eng.php
http://www.hc-sc.gc.ca/sr-sr/biotech/about-apropos/xeno-eng.php
http://www.bio.org/articles/xenotransplantation-benefits-and-risks-special-organ-transplantation
http://www.biotechlearn.org.nz/themes/bioethics/ethics_of_xenotransplantation
http://www.crt-online.org/wrong.html
http://www.nelsonerlick.com/html/xeno_fact_sheet.html
Westall, Glen P., MD., etal., "Sustained function of genetically modified porcine lungs
in an ex vivo model of pulmonary xenotransplantation." The Journal of Heart
and Lung Transplantation 32.NO11 (2013): 1-8. Print.

Sustained function of Genetically Modified Porcine Lungs in Ex Vivo Model of Pulmonary Xenotransplantation
Expectations
Experiment
Results
Importance
Full transcript