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Breast Cancer

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by

Brendan Miller

on 4 April 2014

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Transcript of Breast Cancer

Breast Cancer


Background



Symptoms
Rash of the breast.
Breast lump that feels different.
Detected by mammography and or ultrasound.
Types of Condition
Specific mutations in genes called BRCA1 and BRCA2 are most common.
Cells that are mutated create abnormal protein.
Discovered by: Edwin Smith and George Ebers papyri. Dates back to 3,500 years ago.
Official name
: Ductal Carcinoma, or Lobular Carcinoma.




What is Breast Cancer?
Defined as the cells in the breast region grow abnormally and in an uncontrolled way.
Hereditary Breast and Ovarian Cancer
(HBOC) Mutations among both BRCA1 and BRCA2 genes.
10% to 15% have only one of the two genes mutated.
Stage 1 Breast Cancer
Tumor is 2 cm or smaller and has not spread to the outside of the cell.
Li-Fraumeni Syndrome
Rare disorder that has mutations in the TP53 gene.
70% of families have a mutation in TP53 gene.
Stage 2 Breast Cancer
Patient has a primary cancer either involves axillary lymph nodes and is less than 5 cm in size.
Can be cured with surgery, chemotherapy, radiation therapy and hormonal therapy.
Stage 3 Breast Cancer
Three different stages within stage 3, consist of stage three A, three B, and three C.
Stage IIIA, up to 1 to 3 lymph nodes are found with cancer
Stage IIIB, up to 9 lymph nodes are infected.
Stage IIIC, up to 10 or more lymph nodes are infected.
Stage 4 Breast Cancer
Considered as the worst stage of cancer.
Could spread to other body organs.
Transmission or Spreading
No evidence that Breast Cancer could be spread through touching, close contact, sharing food, or breathing the same air.
Behavioral Risk Factors
Alcohol
Obesity
Dietary patterns
Demographics
Breast Cancer could strike at any age.
Most common age range around 50 and over.
Affected People
Women at any age.
US 200,000 cases discovered.
50,000 people die annually.
Biochemical Changes
Genes Mutated
BRCA 1
BRCA 2
p53

How Breast Cancer Affects Cell Function
Breast tissue is sensitive to developing cancer.
Female hormone estrogen stimulates breast cell division.
Estrogen is mainly produced in ovaries.
Organ Systems Involved
Bone
Brain
Liver
Lung
Breast region
How Person's Daily Life is Affected
Once you find out its cancerous, you never know if you are going to die.
If affected, may have to take chemotherapy.
By: Brendan Miller
Prognosis of Disease
Survival rates vary because each stage of Breast Cancer is different.
Pictures Work Cited
http://www.breast-cancer.ca/survival-statistics/breast-cancer-survival-by-stage.htm
http://ribbons.com/wp-content/uploads/2012/09/breastcancer.jpg
http://www.thirdage.com/files/cond/breast-cancer.jpg
http://upload.wikimedia.org/wikipedia/commons/2/2a/Georg_Ebers.jpg
http://health-advisors.org/wp-content/uploads/2013/04/breast-cancer-symptoms.jpg
http://dnasequencing.yolasite.com/resources/pie-chart.png
http://www.cancer.gov/PublishedContent/Images/images/documents/a3a0ee76-1bc5-4490-aeaa-2248702c668f/cancer44.jpg
http://www.stjude.org/SJFile/hosp-ipactr29-1102.jpg
http://www.cancer.gov/images/cdr/live/CDR732257-750.jpg
http://universitycancercenters.com/wp-content/uploads/2012/09/Stage-II-Breast-Cancer-637x491.jpg
http://www.cancer.gov/images/cdr/live/CDR732260-750.jpg
http://3.bp.blogspot.com/-2Y6j2gBU--k/UlkQ6OSqtaI/AABtU/G7uT7EMqhoQ/s1600/br22_breastcancer_stage2-1.jpg
http://www.lemming-safety.de/shop/images/product_images/original_images/verb_025.jpg
http://i.dailymail.co.uk/i/pix/205DC-531_233x423.jpg
http://www.azureazure.com/files/Images/Bulletins/BodySoul/breast_cancer/Breast-Cancer.jpg
http://www.cancerresearchuk.org/prod_consump/groups/cr_common/@nre/@sta/documents/image/deaths_crude_f_breast_png.png
http://cdn.physorg.com/newman/gfx/news/2013/changestodna.jpg
http://www.uchospitals.edu/images/nci/CDR0000436000.jpg
http://resources0.news.com.au/images/2013/10/02/1226731/479724-oct3_stress.jpg
http://www.breast-cancer.ca/images/survivalstageschart.jpg
http://breastcancerbydrruddy.com/wp-content/uploads/2011/09/radiation11.gif
http://www.ovca.org/wp-content/uploads/2011/08/tamoxifen-ovarian-cancer.jpg
http://free.clipartof.com/63-Free-Retro-Clipart-Illustration-Of-Man-Carrying-Big-Bag-Of-Money-With-Dollar-Sign.jpg

Treatments
Surgery
Radiation Therapy
Chemotherapy
Hormone Therapy
Medications
Tamoxifen
Arimidex
Costs of Disease
Chemotherapy: several thousand to 30 thousand dollars.
Arimidex: per month 40 dollars.
Tamoxifen: 90 days, 20 dollars.
Mastectomy: 6,000 dollars.
Radiation Therapy: ranges to 20,000 dollars.
Conclusion
The most interesting thing I learned from this disease was that there are 4 different stages of the disease. Each stage has different tumor sizes and different treatments. One main source that gave me good information was the American Cancer Society website. Most information was collected there. Everyone should realize that Breast Cancer is very common and could happen at any age. If detected, treat the disease very quickly because you do not want it to spread throughout the body. I have picked this disease because my mother had Breast Cancer and I wanted to know how it was caused.
Work Cited
Martin, Laura J., MD. "Stage I Breast Cancer Treatment Options." WebMD. WebMD, 30 Dec. 0087. Web. 17 Nov. 2013.
Staff, Mayo Clinic. "Definition." Mayo Clinic. Mayo Foundation for Medical Education and Research, 22 May 2013. Web. 17 Nov. 2013.
"What Does the Doctor Look for on a Mammogram?" What Does the Doctor Look for on a Mammogram? American Cancer Society, 08 May 2012. Web. 17 Nov. 2013.
Reed, Martha K. "Learn Which HER2-positive Breast Cancertreatment May Be Right for You." Learn Which HER2-positive Breast Cancer Treatment May Be Right for You. Genentech, 22 Sept. 2013. Web. 17 Nov. 2013.
Davis, Richard. "Arimidex." - Uses, Side Effects, Interactions. N.p., 17 Jan. 2012. Web. 17 Nov. 2013.
Kazmi, Shayma, MD. "Breast Cancer Types." Types of Breast Cancer: Noninvasive & Invasive. Cancer Treatment Center of America, 01 Jan. 2011. Web. 17 Nov. 2013
"Stages 0 & 1." Www.nationalbreastcancer.org. National Breast Cancer Foundation, 8 Aug. 2012. Web. 17 Nov. 2013.

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